Results 31 to 40 of about 10,628,077 (304)

Characterization of recombinant human lactoferrin N-glycans expressed in the milk of transgenic cows.

PLoS ONE, 2017
Lactoferrin (LF) is one of the most abundant bioactive glycoproteins in human milk. Glycans attached through N-glycosidic bonds may contribute to Lactoferrin functional activities. In contrast, LF is present in trace amounts in bovine milk.
Annabelle Le Parc, Sercan Karav, Camille Rouquié, Elizabeth A Maga, Apichaya Bunyatratchata, Daniela Barile   +5 more
doaj   +1 more source

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Frontiers in Immunology, 2018
Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains.
Fleur S. van de Bovenkamp, Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Steven W. de Taeye, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Rogier W. Sanders, Theo Rispens, Theo Rispens   +13 more
doaj   +1 more source

Comparison of denaturing agent effects in enzymatic N-glycan release for human plasma N-glycan analysis

Turkish Journal of Chemistry, 2022
Glycosylation is an essential posttranslational modification observed in the living proteome. Glycosylation profiles in glycoproteins can change in commonly observed diseases such as cancer. Identifying these changes is crucial in discovering new biomarkers for the early diagnosis of cancer.
KAYILI, H. Mehmet, SAKHTA, Rokia, SALİH, Bekir   +2 more
openaire   +2 more sources

Towards Mapping of the Human Brain N-Glycome with Standardized Graphitic Carbon Chromatography

Biomolecules, 2022
The brain N-glycome is known to be crucial for many biological functions, including its involvement in neuronal diseases. Although large structural studies of brain N-glycans were recently carried out, a comprehensive isomer-specific structural analysis ...
Johannes Helm, Lena Hirtler, Friedrich Altmann   +2 more
doaj   +1 more source

Serum Protein N-Glycosylation Signatures of Neuroblastoma

Frontiers in Oncology, 2021
BackgroundNeuroblastoma is the most common extracranial childhood solid tumor which accounts for 10% of the malignancies and 15% of the cancer fatalities in children.
Wenjun Qin, Hao Pei, Xiaobing Li, Jia Li, Xuelian Yao, Rufang Zhang   +5 more
doaj   +1 more source

N-glycans released from glycoproteins using a commercial kit and comprehensively analyzed with a hypothetical database

Journal of Pharmaceutical Analysis, 2017
The glycosylation of proteins is responsible for their structural and functional roles in many cellular activities. This work describes a strategy that combines an efficient release, labeling and liquid chromatography-mass spectral analysis with the use ...
Xue Sun, Lei Tao, Lin Yi, Yilan Ouyang, Naiyu Xu, Duxin Li, Robert J. Linhardt, Zhenqing Zhang   +7 more
doaj   +1 more source

Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition

Exploration of Immunology, 2021
Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect antibody drug characteristics and quality control.
Buyong Ma
doaj   +1 more source

Fragments of bacterial endoglycosidase S and immunoglobulin G reveal subdomains of each that contribute to deglycosylation [PDF]

, 2014
Endoglycosidase S (EndoS) is a glycoside-hydrolase secreted by the bacterium Streptococcus pyogenes. EndoS preferentially hydrolyzes the N-linked glycans from the Fc region of IgG during infection. This hydrolysis impedes Fc functionality and contributes
Yu, Xiaojie, Crispin, Max, Vesiljevic, Snezana, Pritchard, Laura K., Mattick, Susan, Scanlan, Christopher N., Baruah, Kavitha, Schnell, Jason R., Higgins, Matthew K., Krishna, Benjamin, Harvey, David J., Dixon, Emma V., Claridge, Jolyon K., Zitzmann, Nicole   +13 more
core   +1 more source

Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome [PDF]

, 2014
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins.
Scrivens, JH, Crispin, Max, Huiskonen, JT, Scrivens, James H., Bitto, David, Crispin, Matthew, Harvey, David J, Bitto, D, Scrivens, James, Huiskonen, Juha T, Bowden, Thomas A, Crispin, M, Bowden, Thomas A., Scrivens, James H, Edgeworth, Matthew, Halldorsson, Steinar, Huiskonen, Juha T., Bonomelli, Camille, Edgeworth, M, Bowden, TA, Bonomelli, C, Harvey, David J., Harvey, DJ, Halldorsson, S   +23 more
core   +1 more source

Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans

Microbial Cell Factories, 2021
Background Sulfate modification of N-glycans is important for several biological functions such as clearance of pituitary hormones or immunoregulation.
Léa Chuzel, Samantha L. Fossa, Madison L. Boisvert, Samanta Cajic, René Hennig, Mehul B. Ganatra, Udo Reichl, Erdmann Rapp, Christopher H. Taron   +8 more
doaj   +1 more source