Results 21 to 30 of about 537,340 (146)

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance

Nature Communications
Receptor tyrosine kinases (RTKs) play a crucial role in the regulation of intracellular signal transduction, underscoring their significance as targets for drug therapy.
Zhilan Zhou, Yichang Liu, Ya Wang, Hang Jiang, Tingting Chen, Yingdi Zhu, Ting Fu, Juan Li   +7 more
doaj   +1 more source

An Open‐Label, Single‐Arm, Phase II Trial of Sintilimab Plus Anlotinib for Metastatic Non‐Small Cell Lung Cancer After First‐Line PD‐(L)1 Inhibitor

Cancer Medicine
Background Although immune checkpoint inhibitors (ICIs) have markedly improved first‐line management of non‐small cell lung cancer (NSCLC), many tumors eventually escape control after anti‐PD‐(L)1 therapy, leaving a clear therapeutic gap.
Xun Shi, Chen Lin, Lishu Lou, Qiong He, Guangyuan Lou, Wei Hong, Lan Shao, Jun Zhao, Cuiping Gu, Xinmin Yu, Ying Jin   +10 more
doaj   +1 more source

The impact of different clinicopathologic factors and salvage therapies on cervical cancer patients with isolated para-aortic lymph node recurrence

Discover Oncology
Background Cervical cancer patients with isolated para-aortic lymph nodes (PALN) recurrence were mainly associated with treatment failure. For these patients, radiotherapy, chemotherapy, surgery ± adjuvant therapy or chemoradiotherapy may be advised ...
Chenyan Fang, Yinfeng Zhu, Ping Zhang, Tao Zhu, Yingli Zhang   +4 more
doaj   +1 more source

Deep learning-based multimodal pathogenomics integration for precision cancer prognosis

Journal of Translational Medicine
Background Recent studies have revealed valuable prognostic insights in haematoxylin and eosin (H&E)-stained histological sections and transcriptomic profiles, suggesting potential applications in machine learning.
Xiaobing Feng, Ge Song, Ye Zhang, Lu Guo, Yian Jiang, Wangang Gong, Yue Feng, Chunwei Xu, Yang Yang, Min He   +9 more
doaj   +1 more source

Multi-omics analysis reveals that ginsenoside Rb1 improves prognostic outcomes in sepsis by modulating mitochondrial metabolism MTHFD2 targets

Scientific Reports
Sepsis has emerged as a major threat to human mortality. Increasing evidence explores the impact of mitochondrial metabolism on the prognosis of sepsis patients and its therapeutic potential. To enhance risk stratification and identify potential targets,
Qi Shu, Huan Luo, Like Zhong, Jiaping Mo, Xiaoyan Wei, Zhenjie Zhu, Xiaojuan Chen, Han She, Fugen He, Junfeng Zhu   +9 more
doaj   +1 more source

Delineation of intersegmental plane: application of blood flow blocking method in pulmonary segmentectomy

Journal of Cardiothoracic Surgery
Background The Modified Inflation-Deflation Method (MIDM) is widely used in China in pulmonary segmentectomies. We optimized the procedure, which was named as Blood Flow Blocking Method (BFBM), also known as “No-Waiting Segmentectomy”.
Lei Cai, Changchun Wang, Taobo Luo, Shuang Fu, Jingxiao Liang, Xiancong Huang, Chao Pan, Yiding Feng, Wenkui Mo, Haoting Xu, Qixun Chen, Jian Zeng   +11 more
doaj   +1 more source

Extreme Tolerance of Nanoparticle‐Protein Corona to Ultra‐High Abundance Proteins Enhances the Depth of Serum Proteomics

Advanced Science
The serum nanoparticle‐protein corona (NPC) provides specific disease information, thus opening a new avenue for high‐throughput in‐depth proteomics to facilitate biomarker discovery.
Qiqi Liu, Mengjie Wang, Xin Dai, Shuangqin Li, Haoxiang Guo, Haozhe Huang, Yueli Xie, Chenlu Xu, Yuan Liu, Weihong Tan   +9 more
doaj   +1 more source

Proteomic profiling of single extracellular vesicles as a promising new approach for the diagnosis and treatment modality of advanced ovarian cancer

npj Precision Oncology
This study utilized a novel Proximity Barcoding Assay to perform high-resolution proteomic profiling of individual plasma extracellular vesicles from 85 patients with advanced high-grade serous ovarian carcinoma (OC) and 95 healthy controls (HC).
Beier Wu, Xuping Yang, Yanling Cai, Shihan Wan, Jingfang Liu, Jie Xing, Xin Chen, Jiejie Zhang, Yanlu Jin, Aijun Yu, Li Yang   +10 more
doaj   +1 more source

Salidroside enhances NO bioavailability and modulates arginine metabolism to alleviate pulmonary arterial hypertension

European Journal of Medical Research
Background Salidroside (SAL), derived from Rhodiola, shows protective effects in pulmonary arterial hypertension (PAH) models, but its mechanisms are not fully elucidated.
Junfei Li, Zengyu Zhang, Chenghui Zhu, Xiaorong Zheng, Chunlei Wang, Jianwei Jiang, Hongyan Zhang   +6 more
doaj   +1 more source

Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis

Journal of Ovarian Research
Objective Tricho-rhino-phalangeal syndrome-1 (TRPS1), an atypical GATA transcription factor, plays a critical role in diverse physiological and pathological processes and holds potential as a biomarker for diseases and targeted tumor therapies.
Jingfang Liu, Beier Wu, Shihan Wan, Yanlu Jin, Li Yang, Meijuan Wu, Jie Xing, Jiejie Zhang, Xin Chen, Aijun Yu   +9 more
doaj   +1 more source