Results 41 to 50 of about 537,340 (146)

Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy

Molecular Cancer
Cellular senescence has gradually been recognized as a key process, which not only inhibits the occurrence of early tumors but also promotes advanced malignant progression through secretory and immunomodulatory functions.
Huiting Yang, Dong Liu, Liewang Qiu, Rui Wang, Chuchu Zhang, Danqing Yu, Qingping Zhong, Nitta Yuki, Zhentao Song, Taotao Zhu, Haixing Ju, Weifeng Hong, Ji Zhu   +12 more
doaj   +1 more source

Development of Manganese Carbonyl Loaded Upconversion Nanoparticles for Near‐Infrared‐Triggered Carbon Monoxide and Mn2+ Delivery

Advanced NanoBiomed Research
Photoactivatable carbon monoxide‐releasing molecules (CORMs), typically based on transition‐metal carbonyl complexes, have reliance on activation by UV or visible light that restricts their biomedical applications.
Yile Zheng, Yi Wei, Yuying Yang, Xiang Wen, Cai Yang, Yating Xiao, Zhen Du, Xiangsheng Liu   +7 more
doaj   +1 more source

Cisplatin Promotes Immunosuppression in Ovarian Cancer by Enhancing miR‐181a‐5p‐Enriched Extracellular Vesicles to Drive Regulatory T Cell Differentiation

Journal of Extracellular Vesicles
Although cisplatin (CDDP) is widely employed in combination immunotherapy, no CDDP‐based regimen has shown a survival benefit when treating the ovarian cancers. This is mainly because the impact of CDDP on immunotherapy is not fully understood.
Liyan Zheng, Sijia Mu, Mingxue Liu, Panmin Lei, Jingchen Zhang, Yuting Dai, Chenxi He, Fengli Qu, Weihong Tan   +8 more
doaj   +1 more source

The perfect horse : how to know him, how to breed him, how to train him, how to shoe him, how to drive him

, 1873
W. H. H. Murray, Henry Ward Beecher, Henry Ward Beecher, George B. Loring   +3 more
  +8 more sources

Immunohistochemical biomarker-associated radiomics for classifying thymic epithelial tumors: a multicenter retrospective study

npj Precision Oncology
The subtle imaging features of thymic epithelial tumors (TETs), which comprise multiple pathological subtypes of thymoma and thymic carcinoma, are of great significance for the identification of high-risk patients.
Yutian Zhang, Yangzhong Guo, Junyu Li, Haitao Jiang, Yueyu Huang, Bojian Feng, Wenhui Shen, You Xiao, Jiahui Wang, Chang Yu, Changchun Wang, Qiaoli Lv, An Zhao, Weimin Mao   +13 more
doaj   +1 more source

Numerical simulation and in vitro experimental study of the hemodynamic performance of vena cava filters with helical forms

Scientific Reports
Inferior vena cava filter (IVCF) implantation is a common method of thrombus capture. By implanting a filter in the inferior vena cava (IVC), microemboli can be effectively blocked from entering the pulmonary circulation, thereby avoiding acute pulmonary
Yu Xiang Huang, Qi Li, Ming Liu, Ming Zhao, Ying Chen   +4 more
doaj   +1 more source

The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors

Journal of Hematology & Oncology
Antibody-drug conjugates (ADCs) represent an important class of cancer therapies that have revolutionized the treatment paradigm of solid tumors.
Qing Wei, Peijing Li, Teng Yang, Jiayu Zhu, Lu Sun, Ziwen Zhang, Lu Wang, Xuefei Tian, Jiahui Chen, Can Hu, Junli Xue, Letao Ma, Takaya Shimura, Jianmin Fang, Jieer Ying, Peng Guo, Xiangdong Cheng   +16 more
doaj   +1 more source

Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients

Cancer Medicine
Objective Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial. Methods Immunohistochemistry was used to examine expression of positive CD4 cells in 103 patients with FL 1‐3A.
Cong Li, Na Guo, Shuiyun Han, Haifeng Yu, Tao Lei, Xi Chen, Shuailing Peng, Haiyan Yang, Meijuan Wu   +8 more
doaj   +1 more source

Immune checkpoint inhibitors combined with chemotherapy in conversion therapy for stage IV gastric cancer: a multicenter retrospective cohort study

Cancer Immunology, Immunotherapy
Objectives To evaluate the efficacy of combining PD-1 inhibitors with chemotherapy in conversion therapy for patients with stage IV gastric cancer and to determine the populations most likely to benefit from this regimen.
Xingmao Huang, Xiangliu Chen, Jiahui Chen, Can Hu, Han Chen, Hang Chen, Jingquan Fang, Zeyao Ye, Yian Du, Pengfei Yu, Ling Huang   +10 more
doaj   +1 more source

Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation

Molecular Medicine
Background Whereas intestinal epithelial barrier dysfunction is implicated in inflammatory bowel disease (IBD), the underlying mechanisms remain elusive.
Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang   +7 more
doaj   +1 more source