Results 111 to 120 of about 120,668 (359)

Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability

open access: yeseLife, 2019
Mask family proteins were discovered in Drosophila to promote the activity of the transcriptional coactivator Yorkie (Yki), the sole fly homolog of mammalian YAP (YAP1) and TAZ (WWTR1).
Clara Sidor   +5 more
doaj   +1 more source

Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory response [PDF]

open access: yes, 2011
The neural system is less sensitive to radiation than other late-responding organs and tissues such as the kidney and lung. The generation of new neurons in the adult mammalian brain has been documented in several works.
Azami, N.S.   +3 more
core  

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity [PDF]

open access: yes, 2015
SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood.
Biasiolo, Alessandra   +16 more
core   +2 more sources

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

open access: yesAdvanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang   +12 more
wiley   +1 more source

Dung beetles (Coleoptera: Scarabaeidae: Aphodiinae) of the Mpala Research Centre and environs, Laikipia District, Kenya [PDF]

open access: yes, 2008
The dung beetle fauna of the subfamily Aphodiinae occurring in the Laikipia District of Kenya was surveyed. In total, 14 genera and 29 species were found and these taxa are placed in identification keys.
Bordat, Patrice   +3 more
core   +2 more sources

Actin up for Hippo [PDF]

open access: yesThe EMBO Journal, 2011
The Hippo (Hpo) signalling pathway is an evolutionarily conserved pathway controlling tissue growth, but its upstream inputs remain poorly understood. In this issue of The EMBO Journal , Sansores‐Garcia et al (2011) report that modulation of filamentous (F)‐actin accumulation controls Hpo pathway activity. In a related study, Garcia‐Fernandez et al
openaire   +2 more sources

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li   +15 more
wiley   +1 more source

Gender Differences and Digital Learning Games – One Size Does not fit all [PDF]

open access: yes, 2018
The intrinsic motivation demonstrated towards digital games provides the opportunity for its use as a learning tool irrespective of gender differences. This has resulted in the combination of the motivation of games with curricular content referred to as
Bacon, Liz   +2 more
core  

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