Results 1 to 10 of about 23,621 (250)
Distinct prognostic values of YAP1 in gastric cancer [PDF]
Tumor Biology, 2017 The Hippo pathway regulates intrinsic organ sizes by regulating apoptosis and cell proliferation. YAP1 (yes-associated protein 1) is a transcriptional effector of the Hippo pathway.
Lan Yu +6 more
doaj +4 more sources
Ocular phenotypic consequences of a single copy deletion of the Yap1 gene (Yap1+/−) in mice
Molecular Vision, 2019 Purpose: To identify the effects of a single copy deletion of Yap1 (Yap1+/−) in the mouse eye, the ocular phenotypic consequences of Yap1+/− were determined in detail.
Soohyun Kim +6 more
doaj +3 more sources
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis [PDF]
Oncogene, 2020 AbstractHippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads to carcinogenesis. YAP1/TEAD complex activates the oncogenic downstream transcription, such as CTGF and c-Myc. How YAP1 is protected in the cytoplasm from ubiquitin-mediated degradation remains elusive.
Yuhang Zhou +15 more
openaire +3 more sources
YAP1 promotes multidrug resistance of small cell lung cancer by CD74‐related signaling pathways
Cancer Medicine, 2020 Background Our previous research found that YAP1 may have a role in multidrug resistance (MDR) in small cell lung cancer (SCLC). However, its underlying mechanism is unknown.
Yongchun Song +2 more
exaly +2 more sources
Cancer Communications, 2023 Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear.
Yuqing Cui, Xuesong Chen
exaly +2 more sources
A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy [PDF]
International Journal of Cancer, 2018 YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with other cancer promoting pathways. YAP1 contributes to cancer development in various ways that include promoting malignant phenotypes, expansion of cancer stem cells and drug resistance of cancer cells.
Masahiro Shibata, Mohammad O Hoque
exaly +3 more sources
Transcriptional control of PPP2CB by YAP1 and TEAD1 mediates AMPK inhibition and mTORC1 activation in vascular smooth muscle cells. [PDF]
iScienceSummary: We previously demonstrated that the transcriptional co-factor Yes-associated protein 1 (YAP1) promotes vascular smooth muscle cell (VSMC) phenotypic switching and neointima formation. However, the underlying mechanisms remain unclear.
Kumariya S +3 more
europepmc +2 more sources
Molecular Subtypes of High-Grade Neuroendocrine Carcinoma (HGNEC): What is YAP1-Positive HGNEC?
Frontiers in Bioscience-Landmark, 2022 Small cell lung cancer (SCLC) subtype classification, based on high-level expression of key transcriptional regulators; ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P), and YAP1 (SCLC-Y), has recently been proposed.
Hitomi Kawai +3 more
doaj +1 more source
The TGFβ→TAK1→LATS→YAP1 Pathway Regulates the Spatiotemporal Dynamics of YAP1
Molecules and Cells, 2023 The Hippo kinase cascade functions as a central hub that relays input from the "outside world" of the cell and translates it into specific cellular responses by regulating the activity of Yes-associated protein 1 (YAP1). How Hippo translates input from the extracellular signals into specific intracellular responses remains unclear.
Min-Kyu Kim +13 more
openaire +2 more sources
Cell Reports, 2023 Summary: YAP1 functions in lineage differentiation of pluripotent embryonic stem cells (ESCs); however, the detailed mechanisms underlying the regulation of YAP1 activity during ESC differentiation remain elusive.
Ruipeng Zhuge +5 more
doaj +1 more source