Results 1 to 10 of about 32,177 (245)
Neoplasia: An International Journal for Oncology Research, 2021 Increased expression of Yes-associated protein-1 (YAP1) was shown to correlate with reduced survival in breast cancer (BC) patients. However, the exact mechanism of YAP1 regulation in BC cells remains ambiguous.
Jibran Sualeh Muhammad +9 more
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PSME4 Degrades Acetylated YAP1 in the Nucleus of Mesenchymal Stem Cells
Pharmaceutics, 2022 Intensive research has focused on minimizing the infarct area and stimulating endogenous regeneration after myocardial infarction. Our group previously elucidated that apicidin, a histone deacetylase (HDAC) inhibitor, robustly accelerates the cardiac ...
Yong Sook Kim +10 more
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Cell Death and Disease, 2021 Chondrosarcoma (CHS) is the second most common bone malignancy with limited therapeutic approaches. Our previous study has found that Yes associated protein 1 (YAP1) is downregulated in CHS cells treated with bromodomain and extraterminal domain (BET ...
Huan-Tian Zhang +15 more
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Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma
Molecular Oncology, 2020 Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness, and aggressive phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with high YAP1 expression in esophageal cancer (EC).
Shumei Song +14 more
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One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB
Molecular & Cellular Oncology, 2019 The Hippo pathway plays a major role in regulating organ size during embryogenesis. Loss of Hippo signaling can cause cancer due to unrestricted cell proliferation.
Grit Weinstock, Stefan Gaubatz
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Journal of Experimental & Clinical Cancer Research, 2022 Background Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE), a preneoplastic metaplastic ...
Farah Ballout +11 more
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New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression [PDF]
Iranian Journal of Colorectal Research, 2019 Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers.
Fariba Dehghanian +3 more
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Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer
Molecular & Cellular Oncology, 2021 In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in ...
Amanda K. Riley, Alice H. Berger
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miR-375 Inhibits Proliferation of Mouse Pancreatic Progenitor Cells by Targeting YAP1
Cellular Physiology and Biochemistry, 2013 Background/Aims: The Hippo signaling pathway regulates expansion and differentiation of stem cells and tissue progenitor cells during organ development and tissue regeneration.
Zhen-Wu Zhang +5 more
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Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
Cell Reports, 2022 Summary: Inactivation of Capicua (CIC) or upregulation of yes-associated protein 1, YAP1, leads to broad RAS-RAF-MEK-ERK inhibitor resistance and tumor progression in multiple human cancers.
Ji Won Kim +6 more
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