Results 11 to 20 of about 32,177 (245)
Cancer Communications, 2023 Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear.
Xuesong Chen
exaly +2 more sources
Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension [PDF]
Cancer Biology & Medicine, 2017 Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Filiz Kisaayak Collak +4 more
doaj +3 more sources
Transcriptional control of PPP2CB by YAP1 and TEAD1 mediates AMPK inhibition and mTORC1 activation in vascular smooth muscle cells [PDF]
iScienceSummary: We previously demonstrated that the transcriptional co-factor Yes-associated protein 1 (YAP1) promotes vascular smooth muscle cell (VSMC) phenotypic switching and neointima formation. However, the underlying mechanisms remain unclear.
Sanjana Kumariya +3 more
doaj +2 more sources
YAP1 inhibition protects retinal vascular endothelial cells under high glucose by inhibiting autophagy [PDF]
Open Life SciencesDiabetic retinopathy (DR) is a frequent diabetes‐associated microvascular disorder, and its underlying mechanism of pathogenesis remains unclear. Previous studies have suggested that YAP1 is involved in endothelial activation and vascular inflammation ...
Li Yu-Shan +4 more
doaj +2 more sources
Distinct prognostic values of YAP1 in gastric cancer [PDF]
Tumor Biology, 2017 The Hippo pathway regulates intrinsic organ sizes by regulating apoptosis and cell proliferation. YAP1 (yes-associated protein 1) is a transcriptional effector of the Hippo pathway.
Lan Yu +6 more
doaj +3 more sources
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis [PDF]
Oncogene, 2020 AbstractHippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads to carcinogenesis. YAP1/TEAD complex activates the oncogenic downstream transcription, such as CTGF and c-Myc. How YAP1 is protected in the cytoplasm from ubiquitin-mediated degradation remains elusive.
Yuhang Zhou +15 more
openaire +2 more sources
Molecular Subtypes of High-Grade Neuroendocrine Carcinoma (HGNEC): What is YAP1-Positive HGNEC?
Frontiers in Bioscience-Landmark, 2022 Small cell lung cancer (SCLC) subtype classification, based on high-level expression of key transcriptional regulators; ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P), and YAP1 (SCLC-Y), has recently been proposed.
Hitomi Kawai +3 more
doaj +1 more source
Ocular phenotypic consequences of a single copy deletion of the Yap1 gene (Yap1+/−) in mice
Molecular Vision, 2019 Purpose: To identify the effects of a single copy deletion of Yap1 (Yap1+/−) in the mouse eye, the ocular phenotypic consequences of Yap1+/− were determined in detail.
Soohyun Kim +6 more
doaj +2 more sources
Cell Reports, 2023 Summary: YAP1 functions in lineage differentiation of pluripotent embryonic stem cells (ESCs); however, the detailed mechanisms underlying the regulation of YAP1 activity during ESC differentiation remain elusive.
Ruipeng Zhuge +5 more
doaj +1 more source
Cell Cycle, 2010 Comment on: Hamilton G, et al. ATM regulates a RASSF1A-dependent DNA damage response. Curr Biol 2009; 19:2020-5.
Yee, K, O'Neill, E
openaire +2 more sources