Results 11 to 20 of about 23,828 (263)

Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation [PDF]

Cell Cycle, 2016
The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. The pivotal effector of this pathway is YAP1, a transcriptional co-activator amplified in mouse and human cancers where it promotes epithelial-to-mesenchymal transition (EMT) and malignant transformation.
Ying-Wei, Li, Jin, Guo, He, Shen, Jun, Li, Nuo, Yang, Costa, Frangou, Kayla E, Wilson, Yinglong, Zhang, Ashley L, Mussell, Marius, Sudol, Amjad, Farooq, Jun, Qu, Jianmin, Zhang   +12 more
openaire   +4 more sources

The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1 [PDF]

Journal of Translational Medicine, 2023
Abstract Background Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pathway, and its abnormality leads to neurofibromatosis type 1 (NF-1) disease. However, the role
Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu, Ying Huang   +9 more
openaire   +4 more sources

Requirement for YAP1 signaling in myxoid liposarcoma [PDF]

EMBO Molecular Medicine, 2019
Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the FUS-DDIT3 fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS-DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elusive.
Marcel Trautmann, Ya‐Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Ruth Berthold, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders Ståhlberg, Pierre Åman, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann, Stefan Fröhling   +23 more
openaire   +6 more sources

Interhemispheric Pediatric Meningioma, YAP1 Fusion-Positive [PDF]

Diagnostics, 2022
Meningiomas are uncommon in children and usually arise in the context of tumor-predisposing syndromes. Recently, YAP1-fusions have been identified for the first time as potential NF2-independent oncogenic drivers in the development of meningiomas in pediatric patients.
Silvia Esposito, Gianluca Marucci, Manila Antonelli, Evelina Miele, Piergiorgio Modena, Marzia Giagnacovo, Maura Massimino, Veronica Biassoni, Matilde Taddei, Marco Schiariti, Fabio Doniselli, Marco Moscatelli, Luisa Chiapparini, Bianca Pollo   +13 more
openaire   +6 more sources

USP24 promotes hepatocellular carcinoma progression by deubiquitinating and stabilizing YAP1 [PDF]

Cancer Cell International
Yes-associated protein 1 (YAP1) plays a pivotal role in promoting the progression of hepatocellular carcinoma (HCC). Emerging evidence shows that inducing YAP1 degradation represents a promising strategy.
Huizhuang Shan, Jiaguo Yuan, Luhua Xian, Wenmin Li, Yanfen Ge, Lei Zhang, Ting Lin, Mingwei Lan, Junru Liu, Yanfei Luo, Yingli Wu, Xinhua Xiao   +11 more
doaj   +2 more sources

CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression

Cancer Biology & Therapy, 2023
CircRNAs have been proven to play a pivotal role in cancer progression. The present study aims to explore the roles and related mechanisms of circSETD2 in breast cancer proliferation, migration and invasion. The expression of circSETD2 in BC was assessed
Lan Jing, Liu Yang, Cao Jianbo, Wan Yuqiu, Zhou Yehui   +4 more
doaj   +1 more source

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma [PDF]

Journal of Clinical Investigation, 2019
Poroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The present study aimed to explore the potential role of gene fusions in the tumorigenesis of poromas. RNA sequencing and reverse transcription PCR identified highly recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poromas (92/104 lesions, 88.5%) and their rare malignant ...
Shigeki Sekine, Tohru Kiyono, Eijitsu Ryo, Reiko Ogawa, Susumu Wakai, Hitoshi Ichikawa, Koyu Suzuki, Satoru Arai, Koji Tsuta, Mitsuaki Ishida, Yuko Sasajima, Naoki Goshima, Naoya Yamazaki, Taisuke Mori   +13 more
openaire   +2 more sources

Yap1-2 Isoform Is the Primary Mediator in TGF-β1 Induced EMT in Pancreatic Cancer

Frontiers in Oncology, 2021
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive human malignancy and intrinsically resistant to conventional therapies. YAP1, as a key downstream effector of the Hippo pathway, plays an important role in tumorigenesis including PDAC ...
Chao Gao, Mei-Yu Quan, Qian-Jie Chen, Ruo Yang, Yuanyuan Wu, Jia-Yu Liu, Zhong-Yuan Lin, Xue Li, Jue-Ting Cai, Tian-Fang Jiang, Le Xu, Majid Mossahebi-Mohammadi, Qiang Guo, Jin-San Zhang, Jin-San Zhang   +14 more
doaj   +1 more source

hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation

Cell Reports, 2023
Summary: YAP1 functions in lineage differentiation of pluripotent embryonic stem cells (ESCs); however, the detailed mechanisms underlying the regulation of YAP1 activity during ESC differentiation remain elusive.
Ruipeng Zhuge, Chao Wang, Jie Wang, Shuyu Yu, Liming Liao, Xiaofeng Zheng   +5 more
doaj   +1 more source

Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages

Cells, 2020
Background: Tumor-associated macrophages (TAMs) constitute a major portion of the leukocyte infiltrate found in breast cancer (BC). BC cells may reprogram TAMs in a pro-angiogenic and immunosuppressive sense.
Sara Donzelli, Andrea Sacconi, Chiara Turco, Enzo Gallo, Elisa Milano, Ilaria Iosue, Giovanni Blandino, Francesco Fazi, Giulia Fontemaggi   +8 more
doaj   +1 more source