Results 31 to 40 of about 32,177 (245)

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma [PDF]

open access: yesArteriosclerosis, Thrombosis, and Vascular Biology, 2021
Epithelioid hemangioendothelioma, first described in early 1980s,is a rare malignant vascular neoplasm with significant morbidity and mortality. Approximately 50% of epithelioid hemangioendotheliomas exhibit intravascular endothelial growth, yet their cellular origin, pathogenesis, and effective treatment remain undefined.
Roy Jung   +6 more
openaire   +3 more sources

Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape [PDF]

open access: yes, 2013
Peer reviewedPublisher ...
Alarco AM   +12 more
core   +1 more source

Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]

open access: yes, 2018
Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core   +1 more source

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. [PDF]

open access: yes, 2015
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes.
A Kapoor   +67 more
core   +2 more sources

HepaticYAP1-TFE3Rearranged Epithelioid Hemangioendothelioma

open access: yesCase Reports in Gastrointestinal Medicine, 2019
Epithelioid hemangioendothelioma (EHE) is an uncommon low-grade malignant vascular tumor that may arise in soft tissue/bone or visceral sites such as the liver and lung. As this tumor exhibits epithelioid morphology, it frequently causes diagnostic confusion with other epithelioid vascular neoplasms as well as carcinoma.
Mira M. Lotfalla   +8 more
openaire   +4 more sources

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas [PDF]

open access: yes, 2018
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with ...
Abdel-Rahman, Mohamed H.   +784 more
core   +2 more sources

Pan-urologic cancer genomic subtypes that transcend tissue of origin [PDF]

open access: yes, 2017
Urologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of ...
Bossé, Dominick   +9 more
core   +2 more sources

Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival. [PDF]

open access: yes, 2018
Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious treatment modalities. Elucidation of signaling mechanisms that will lead to the identification of novel targets for therapy and chemoprevention is urgently needed ...
Eibl, Guido   +2 more
core   +2 more sources

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]

open access: yes, 2016
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa   +2 more
core   +1 more source

YAP1 is essential for malignant mesothelioma tumor maintenance

open access: yesBMC Cancer, 2022
AbstractMalignant pleural mesothelioma, a tumor arising from the membrane covering the lungs and the inner side of the ribs, is a cancer in which genetic alterations of genes encoding proteins that act on or are part of the Hippo-YAP1 signaling pathway are frequent.
Loreley Calvet   +14 more
openaire   +3 more sources

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