Results 31 to 40 of about 23,828 (263)

Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

Cell Death and Disease, 2021
Chondrosarcoma (CHS) is the second most common bone malignancy with limited therapeutic approaches. Our previous study has found that Yes associated protein 1 (YAP1) is downregulated in CHS cells treated with bromodomain and extraterminal domain (BET ...
Huan-Tian Zhang, Tao Gui, Ri-Xu Liu, Kui-Leung Tong, Chong-Jie Wu, Zhenyan Li, Xun Huang, Qiu-Tong Xu, Jie Yang, Wang Tang, Yuan Sang, Wanting Liu, Ning Liu, Ryan D. Ross, Qing-Yu He, Zhen-Gang Zha   +15 more
doaj   +1 more source

Yap1 regulates dendritic tree complexity. [PDF]

, 2019
(A) Efficacy of Yap1 shRNA in neurons, analyzed by western blot. (B) Rat hippocampal neurons were transfected on DIV7 with the indicated constructs. An empty pLKO plasmid was used as the control. (C, D) Quantification of TDL (C) and Sholl analysis (D) of
Hubert Doleżyczek (6654860), Leszek Kaczmarek (259569), Joanna Krzemień (244587), Paweł M. Boguszewski (6654863), Marcin Rylski (3141378), Tomasz J. Prószyński (6654869), Witold Konopka (6654866), Jacek Jaworski (416047), Lars Holmgren (14940), Katarzyna O. Rojek (6654857)   +9 more
core   +1 more source

One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB

Molecular & Cellular Oncology, 2019
The Hippo pathway plays a major role in regulating organ size during embryogenesis. Loss of Hippo signaling can cause cancer due to unrestricted cell proliferation.
Grit Weinstock, Stefan Gaubatz
doaj   +1 more source

YAP1/TEAD1 associate with active enhancers. [PDF]

, 2015
(A) Genomic distribution of YAP1/TEAD1 peaks. Promoter class defined as 2kb upstream of gene TSS. (B) Distance of YAP1/TEAD1 peaks and H3K27ac regions to closest gene TSS.
Anaïs Flore Bardet (785780), Tobias Schmelzle (138546), Andreas Bauer (401758), Alexandra Ruchti (785782), Guglielmo Roma (155263), Sebastian Bergling (785781), Ieuan Clay (115922), Claudia Stein (170785), Claudia Agarinis (785783), Dirk Schübeler (218960), Tewis Bouwmeester (4352)   +10 more
core   +1 more source

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

Molecular Oncology, 2020
Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness, and aggressive phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with high YAP1 expression in esophageal cancer (EC).
Shumei Song, Yuan Li, Yan Xu, Lang Ma, Melissa Pool Pizzi, Jiankang Jin, Ailing W Scott, Longfei Huo, Ying Wang, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Namita D Shanbhag, Randy L. Johnson, Jaffer A. Ajani   +14 more
doaj   +1 more source

APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas

Journal of Experimental & Clinical Cancer Research, 2022
Background Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE), a preneoplastic metaplastic ...
Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng, Wael El-Rifai   +11 more
doaj   +1 more source

Yap1 deletion in neurons affects cerebellar morphology. [PDF]

, 2019
(A) Strategy for generating Yap1 conditional knockout mice, showing the Yap1 flox allele (upper diagram) and recombined allele after Cre-mediated excision (lower diagram).
Hubert Doleżyczek (6654860), Leszek Kaczmarek (259569), Joanna Krzemień (244587), Paweł M. Boguszewski (6654863), Marcin Rylski (3141378), Tomasz J. Prószyński (6654869), Witold Konopka (6654866), Jacek Jaworski (416047), Lars Holmgren (14940), Katarzyna O. Rojek (6654857)   +9 more
core   +1 more source

Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

Cell Reports, 2022
Summary: Inactivation of Capicua (CIC) or upregulation of yes-associated protein 1, YAP1, leads to broad RAS-RAF-MEK-ERK inhibitor resistance and tumor progression in multiple human cancers.
Ji Won Kim, Cuyler Luck, Wei Wu, Rovingaile Kriska Ponce, Yone Kawe Lin, Nehal Gupta, Ross A. Okimoto   +6 more
doaj   +1 more source

YAP1 peaks are co-occupied by TEAD1. [PDF]

, 2015
(A) Expression changes of a YAP1/TEAD responsive luciferase reporter upon siRNA-mediated knockdown of YAP1 or TEADs normalized to a negative control siRNA in SF268 cells. (B) Correlation between TEAD1 and YAP1 SF268 ChIP-seq samples. (C) Genomic views of
Anaïs Flore Bardet (785780), Tobias Schmelzle (138546), Andreas Bauer (401758), Alexandra Ruchti (785782), Guglielmo Roma (155263), Sebastian Bergling (785781), Ieuan Clay (115922), Claudia Stein (170785), Claudia Agarinis (785783), Dirk Schübeler (218960), Tewis Bouwmeester (4352)   +10 more
core   +1 more source

A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer [PDF]

, 2017
Data source: Supplementary Information, http://www.nature.com/onc/journal/v36/n1/suppinfo/onc2016185s1.htmlMicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression ...
Hollier, B., Tilley, W.D., Hollier, B.G., Centenera, M., Das, R., Sweeney, K., Tilley, W., Townley, S.L., Selth, L.A., Nelson, C.C., Selth, L., Nelson, C., Zoubeidi, A., Goodall, G., Hanson, A.R., Hanson, A., Gregory, P., Stylianou, N., Gregory, P.A., Townley, S., Jovanovic, L., Centenera, M.M., Coutinho, I., Soekmadji, C., Butler, L., Goodall, G.J., Butler, L.M.   +26 more
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