Results 31 to 40 of about 23,621 (250)

Yap1 is required for maintenance of adult RPE differentiation [PDF]

The FASEB Journal, 2020
Abstract Nuclear YAP1 plays a critical role in regulation of stem cell proliferation, tissue regeneration, and organ size in many types of epithelia. Due to rapid turnover of most epithelial cell types, the cytoplasmic function of YAP1 in epithelial cells has not been well studied.
Qingxian, Lu, Patrick A, Scott, Eric V, Vukmanic, Henry J, Kaplan, Douglas C, Dean, Qiutang, Li   +5 more
openaire   +2 more sources

YAP1/TAZ drives ependymoma-like tumour formation in mice

, 2020
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to ...
Marie-Charlotte Dolmart (8848991), John-Paul Kilday (4112089), Lucy Collinson (3507032), Ambrosius Snijders (4917097), Helen Flynn (2193316), Federico Roncaroli (1931995), Jun-Hao Mao (8849000), Barry Thompson (8849003), Felipe Andreiuolo (181584), Stuart Horswell (594411), Andre Teixeira Lopes (8848994), Torsten Pietsch (38456), Sila K Ultanir (8849006), Noreen Eder (6103226), Suzanne Claxton (8848997)   +14 more
core   +3 more sources

New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression [PDF]

Iranian Journal of Colorectal Research, 2019
Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers.
Fariba Dehghanian, Zahra Azhir, Atefeh Akbari, Zohreh Hojati   +3 more
doaj  

Nucleo-cytoplasmic distribution of YAP1.

, 2022
(A) Immunofluorescence staining of YAP1 together with DAPI and occludin-mEmerald. Static control above and compressed sample below. Scale bars 30 μm. (B) Nucleo-cytoplasmic ratio of YAP1 signal in static controls and compressed samples. P-value < 0.0001 (
Pasi Kallio (3412838), Soile Nymark (668699), Teemu O. Ihalainen (263165), Elina Mäntylä (51470), Heidi Peussa (12769831), Antti-Juhana Mäki (5196785), Joose Kreutzer (4244632)   +6 more
core   +1 more source

APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas

Journal of Experimental & Clinical Cancer Research, 2022
Background Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE), a preneoplastic metaplastic ...
Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng, Wael El-Rifai   +11 more
doaj   +1 more source

The Regulation and Function of YAP1 [PDF]

, 2016
Yes-associated protein 1 (YAP1) is a transcriptional regulator that was first described as part of the Hippo signalling cascade. In the last five years, several others regulators have been identified, placing YAP1 at the centre of a much more complex ...
Ege, NM
openaire   +2 more sources

Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion

, 2014
Oxidative folding of secretory proteins in the endoplasmic reticulum (ER) is a redox active process, which also impacts the redox conditions in the cytosol. As the transcription factor Yap1 is involved in the transcriptional response to oxidative stress,
Stephan Hann, Alexandra B. Graf, Gunda Koellensperger, Marizela Delic, Diethard Mattanovich, Brigitte Gasser, Christina Haberhauer-Troyer   +6 more
core   +1 more source

miR-375 Inhibits Proliferation of Mouse Pancreatic Progenitor Cells by Targeting YAP1

Cellular Physiology and Biochemistry, 2013
Background/Aims: The Hippo signaling pathway regulates expansion and differentiation of stem cells and tissue progenitor cells during organ development and tissue regeneration.
Zhen-Wu Zhang, Tong Men, Rui-Cheng Feng, Yun-Chao Li, Di Zhou, Chun-Bo Teng   +5 more
doaj   +1 more source

YAP1 oncogene and its eight isoforms [PDF]

Oncogene, 2012
Fernandez-L et al.1 and Liu et al.2 reported functional analyses of the human YAP1 gene using overexpression of its complementary DNA (cDNA) in various cell lines. Interestingly, in these reports one of the eight existing isoforms of YAP1 cDNA was used, namely YAP1 encoding 504 amino acid long protein.
openaire   +2 more sources

YAP1/TEAD1 target genes.

, 2015
(A) Gene expression of target genes from all, proximal (≤2Kb), distal (>2Kb) or random YAP1/TEAD1 peaks. Peaks were assigned to their closest gene TSS.
Anaïs Flore Bardet (785780), Tobias Schmelzle (138546), Andreas Bauer (401758), Alexandra Ruchti (785782), Guglielmo Roma (155263), Sebastian Bergling (785781), Ieuan Clay (115922), Claudia Stein (170785), Claudia Agarinis (785783), Dirk Schübeler (218960), Tewis Bouwmeester (4352)   +10 more
core   +1 more source