Results 51 to 60 of about 23,621 (250)

YAP1/TEAD1 associate with active enhancers.

, 2015
(A) Genomic distribution of YAP1/TEAD1 peaks. Promoter class defined as 2kb upstream of gene TSS. (B) Distance of YAP1/TEAD1 peaks and H3K27ac regions to closest gene TSS.
Anaïs Flore Bardet (785780), Tobias Schmelzle (138546), Andreas Bauer (401758), Alexandra Ruchti (785782), Guglielmo Roma (155263), Sebastian Bergling (785781), Ieuan Clay (115922), Claudia Stein (170785), Claudia Agarinis (785783), Dirk Schübeler (218960), Tewis Bouwmeester (4352)   +10 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Yap1 deletion in neurons affects cerebellar morphology.

, 2019
(A) Strategy for generating Yap1 conditional knockout mice, showing the Yap1 flox allele (upper diagram) and recombined allele after Cre-mediated excision (lower diagram).
Hubert Doleżyczek (6654860), Leszek Kaczmarek (259569), Joanna Krzemień (244587), Paweł M. Boguszewski (6654863), Marcin Rylski (3141378), Tomasz J. Prószyński (6654869), Witold Konopka (6654866), Jacek Jaworski (416047), Lars Holmgren (14940), Katarzyna O. Rojek (6654857)   +9 more
core   +1 more source

The role of YAP1 in survival prediction, immune modulation, and drug response: A pan-cancer perspective

Frontiers in Immunology, 2022
IntroductionDysregulation of the Hippo signaling pathway has been implicated in multiple pathologies, including cancer, and YAP1 is the major effector of the pathway.
Xueqing Hu, Xueqing Hu, Yingru Zhang, Yingru Zhang, Hao Yu, Yiyang Zhao, Yiyang Zhao, Xiaoting Sun, Xiaoting Sun, Qi Li, Qi Li, Yan Wang, Yan Wang   +12 more
doaj   +1 more source

PTPN14 is required for the density-dependent control of YAP1 [PDF]

Genes & Development, 2012
Through an shRNA-mediated loss-of-function screen, we identified PTPN14 as a potential tumor suppressor. PTPN14 interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway. We showed that PTPN14 promotes the nucleus-to-cytoplasm translocation of YAP1 during contact inhibition and thus inhibits YAP1 transactivation activity ...
Wenqi, Wang, Jun, Huang, Xin, Wang, Jingsong, Yuan, Xu, Li, Lin, Feng, Jae-Il, Park, Junjie, Chen   +7 more
openaire   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. [PDF]

PLoS ONE, 2012
BACKGROUND: The Hippo pathway regulates organ size by inhibiting cell proliferation and promoting cell apoptosis upon its activation. The Yes Associated Protein 1 (YAP1) is a nuclear effector of the Hippo pathway that promotes cell growth as a ...
Caroline H Diep, Kelly M Zucker, Galen Hostetter, Aprill Watanabe, Chengcheng Hu, Ruben M Munoz, Daniel D Von Hoff, Haiyong Han   +7 more
doaj   +1 more source

PKCι and YAP1 are crucial in promoting pancreatic tumorigenesis [PDF]

Oncotarget, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant disease with 5-year survival rate of less than 6%. Activating mutations of Kras (mu-Kras) are often detected in most of PDAC patients. Although it has been known that oncogenic Kras is the driver of pancreatic cancer initiation and development, the underlying mechanisms by which mu-Kras ...
Wang, Peipei, Wei, Dapeng, Zhang, Hongmei, Chen, Jiao, Zhang, Dingding, Ganapathy, Suthakar, Isakson, Pauline, Chen, Changyan, Zhu, Tongbo   +8 more
openaire   +2 more sources