Results 51 to 60 of about 23,828 (263)

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice

Genes & Development, 2022
YAP1 is a transcriptional coactivator regulated by the Hippo signaling pathway, including NF2. Meningiomas are the most common primary brain tumors; a large percentage exhibit heterozygous loss of chromosome 22 (harboring the NF2 gene) and functional inactivation of the remaining NF2 copy, implicating oncogenic YAP activity in these tumors.
Frank Szulzewsky, Sonali Arora, Aleena K.S. Arakaki, Philipp Sievers, Damian A. Almiron Bonnin, Patrick J. Paddison, Felix Sahm, Patrick J. Cimino, Taranjit S. Gujral, Eric C. Holland   +9 more
openaire   +2 more sources

The Regulation and Function of YAP1 [PDF]

, 2016
Yes-associated protein 1 (YAP1) is a transcriptional regulator that was first described as part of the Hippo signalling cascade. In the last five years, several others regulators have been identified, placing YAP1 at the centre of a much more complex ...
Ege, NM
openaire   +3 more sources

Amot regulates neuronal dendritic tree through Yap1 [PDF]

, 2018
The Amot-Yap1 complex plays a major role in the regulation of cell contact inhibition, cellular polarity and growth. However, the function of Angiomotin (Amot) and Hippo pathway transcription co-activator Yap1 in the central nervous system remains ...
Joanna Krzemień, Hubert Doleżyczek, Katarzyna O. Rojek, Witold Konopka, Marcin Rylski, Jacek Jaworski, Lars Holmgren, Tomasz J. Prószyński, Leszek Kaczmarek, Paweł M. Boguszewski   +9 more
core   +1 more source

DataSheet1_Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.PDF [PDF]

, 2022
Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909), Kienna Matus (11497906), Tadanori Mammoto (72440), Kathryn Hendee (11497903), Sridhar Rao (3534197), Diana M. Tabima (12104945), Akiko Mammoto (148118), Sang H. Lee (7455065), Tendai Hunyenyiwa (11497900), Naomi C. Chesler (12104948)   +9 more
core   +1 more source

YAP1 oncogene and its eight isoforms [PDF]

Oncogene, 2012
Fernandez-L et al.1 and Liu et al.2 reported functional analyses of the human YAP1 gene using overexpression of its complementary DNA (cDNA) in various cell lines. Interestingly, in these reports one of the eight existing isoforms of YAP1 cDNA was used, namely YAP1 encoding 504 amino acid long protein.
openaire   +2 more sources

Mechanism underlying Amot- and Yap1-mediated dendritogenesis. [PDF]

, 2019
(A, B) Reduction of phosphorylation of S6 ribosomal protein in cerebellar homogenates from Amot fl/fl;Syn-Cre (A) and Yap1 fl/fl;Syn-Cre (B) P30 mice, analyzed by western blot (see also S11A and S11B Fig for additional blots and quantification).
Hubert Doleżyczek (6654860), Leszek Kaczmarek (259569), Joanna Krzemień (244587), Paweł M. Boguszewski (6654863), Marcin Rylski (3141378), Tomasz J. Prószyński (6654869), Witold Konopka (6654866), Jacek Jaworski (416047), Lars Holmgren (14940), Katarzyna O. Rojek (6654857)   +9 more
core   +1 more source

Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration [PDF]

, 2022
Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Chesler, Naomi C, Mammoto, Tadanori, Hendee, Kathryn, Mammoto, Akiko, Rao, Sridhar, Matus, Kienna, Lee, Sang H, Tabima, Diana M, Kyi, Priscilla, Hunyenyiwa, Tendai   +9 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

DataSheet6_Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.PDF [PDF]

, 2022
Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909), Kienna Matus (11497906), Tadanori Mammoto (72440), Kathryn Hendee (11497903), Sridhar Rao (3534197), Diana M. Tabima (12104945), Akiko Mammoto (148118), Sang H. Lee (7455065), Tendai Hunyenyiwa (11497900), Naomi C. Chesler (12104948)   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source