Results 51 to 60 of about 32,177 (245)
HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity [PDF]
International Journal of Molecular Sciences, 2019 The Hippo pathway is important for tissue homeostasis, regulation of organ size and growth in most tissues. The co-transcription factor yes-associated protein 1 (YAP1) serves as a main downstream effector of the Hippo pathway and its dysregulation increases cancer development and blocks colonic tissue repair.
Sylvester Larsen +4 more
openaire +4 more sources
Altered microRNA expression profiles in large offspring syndrome and Beckwith-Wiedemann syndrome
Epigenetics, 2019 The use of assisted reproductive technologies (ART) can induce a congenital overgrowth condition in humans and ruminants, namely Beckwith-Wiedemann syndrome (BWS) and large offspring syndrome (LOS), respectively.
Yahan Li +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
14-3-3σ regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression [PDF]
, 2016 Gemcitabine is an important anticancer therapeutics approved for treatment of several human cancers including locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).
Dong, Zizheng, Qin, Li, Zhang, Jian-Ting
core +1 more source
Biomedicine & Pharmacotherapy, 2020 Osteoporosis is a systemic bone disease resulting from decreased bone mass and bone microstructure degeneration. Yes-associated protein 1 (YAP1) belongs to YAP family and plays a significant part in controlling bone quality.Present study aimed to study the function and up-stream mechanism of YAP1 in the differentiation of BMSCs (bone marrow stromal ...
Yongxiong Huang +6 more
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix
Advanced Functional Materials, EarlyView.Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt +2 more
wiley +1 more source
RGC1/RGC2 deletions cause increased sensitivity to oxidative stress in Saccharomyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression [PDF]
, 2016 Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the next generation of antifungal drugs. Rgc1 and Rgc2 are paralogous proteins that regulate the Fps1 glycerol channel in hyperosmotic stress.
Tsai, Michelle
core +1 more source
, 2019 Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (U PR), which enhances protein folding to restore homeostasis.
Aviram +87 more
core +1 more source
YAP1 (Yes-associated protein 1, 65kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on YAP1 (Yes-associated protein 1, 65kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
Di, Agostino S, Strano, S, Blandino, G
openaire +2 more sources