Results 61 to 70 of about 23,621 (250)

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

YAP1 peaks are co-occupied by TEAD1.

, 2015
(A) Expression changes of a YAP1/TEAD responsive luciferase reporter upon siRNA-mediated knockdown of YAP1 or TEADs normalized to a negative control siRNA in SF268 cells. (B) Correlation between TEAD1 and YAP1 SF268 ChIP-seq samples. (C) Genomic views of
Anaïs Flore Bardet (785780), Tobias Schmelzle (138546), Andreas Bauer (401758), Alexandra Ruchti (785782), Guglielmo Roma (155263), Sebastian Bergling (785781), Ieuan Clay (115922), Claudia Stein (170785), Claudia Agarinis (785783), Dirk Schübeler (218960), Tewis Bouwmeester (4352)   +10 more
core   +1 more source

A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair

Advanced Science, EarlyView.
A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao, Xinyu Wang, Zhifeng Wu, Xinya Zhang, Xiao Geng, Ti Zhang, Yue Wang, Hongwei Xia, Jun Zhang, Xianbo Qiu, Cuiru Sun, Yingjie Yu, Wenli Dai, Hua Tian, Qing Cai   +14 more
wiley   +1 more source

A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer

, 2017
Data source: Supplementary Information, http://www.nature.com/onc/journal/v36/n1/suppinfo/onc2016185s1.htmlMicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression ...
Hollier, B., Tilley, W.D., Hollier, B.G., Centenera, M., Das, R., Sweeney, K., Tilley, W., Townley, S.L., Selth, L.A., Nelson, C.C., Selth, L., Nelson, C., Zoubeidi, A., Goodall, G., Hanson, A.R., Hanson, A., Gregory, P., Stylianou, N., Gregory, P.A., Townley, S., Jovanovic, L., Centenera, M.M., Coutinho, I., Soekmadji, C., Butler, L., Goodall, G.J., Butler, L.M.   +26 more
core   +1 more source

YAP1::KMT2A fusion-positive sarcoma: An emerging soft tissue tumor entity with morphological features resembling a sclerosing epithelioid fibrosarcoma

Indian Journal of Pathology and Microbiology
Sclerosing epithelioid fibrosarcoma (SEF) and low-grade fibromyxoid sarcoma (LGFMS) constitute a morphological continuum with certain overlapping histopathological features and MUC 4 immunopositivity.
Ayush Agarwal, Bharat Rekhi, Vineeta Goel, Jyoti Bajpai, Sameer Rastogi   +4 more
doaj   +1 more source

Decreased expression of miR-132 in CRC tissues and its inhibitory function on tumor progression

Open Life Sciences, 2016
Objectives Colorectal cancer (CRC) is among the most common types of malignancies in the worldwide, and microRNAs (miRNAs) emerge as key regulators in carcinogenesis and tumor progression.
Yong Chen, Xiao-lu Han, Xiao-xiang Yin, Yun Zhou, Tao Wu   +4 more
doaj   +1 more source

YAP1 protects against septic liver injury via ferroptosis resistance

Cell & Bioscience, 2022
Background The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly emerged form of lytic cell death, has been implicated in sepsis related organ failure.
Jin Wang, Qian Zhu, Rui Li, Jing Zhang, Xujun Ye, Xinyi Li   +5 more
doaj   +1 more source

Yap1: A DNA damage responder in Saccharomyces cerevisiae [PDF]

Mechanisms of Ageing and Development, 2012
Activation of signaling pathways in response to genotoxic stress is crucial for cells to properly repair DNA damage. In response to DNA damage, intracellular levels of reactive oxygen species increase. One important function of such a response could be to initiate signal transduction processes.
Lori A, Rowe, Natalya, Degtyareva, Paul W, Doetsch   +2 more
openaire   +2 more sources

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity [PDF]

, 2019
The Hippo pathway is important for tissue homeostasis, regulation of organ size and growth in most tissues. The co‐transcription factor yes‐associated protein 1 (YAP1) serves as a main downstream effector of the Hippo pathway and its dysregulation ...
Davidsen, Johanne, Sylvester Larsen, Pedersen, Ole B., Dahlgaard, Katja, Johanne Davidsen, Ole B. Pedersen, Jesper T. Troelsen, Larsen, Sylvester, Troelsen, Jesper T, Troelsen, Jesper Thorvald, Katja Dahlgaard   +10 more
core   +1 more source