Results 71 to 80 of about 23,828 (263)
Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in
mSphere, 2019 AP-1-like transcription factors play evolutionarily conserved roles as redox sensors in eukaryotic oxidative stress responses. In this study, we aimed to elucidate the regulatory mechanism of an atypical yeast AP-1-like protein, Yap1, in the stress ...
Yee-Seul So +12 more
doaj +1 more source
Frontiers in Immunology, 2022 IntroductionDysregulation of the Hippo signaling pathway has been implicated in multiple pathologies, including cancer, and YAP1 is the major effector of the pathway.
Xueqing Hu +12 more
doaj +1 more source
Die Funktion von YAP1 in der Progredienz des Neuroblastoms [PDF]
, 2022 Neuroblastoma is a pediatric solid tumor, that originates from the developing sympathetic nervous system and typically occurs in the adrenal medulla and paraspinal ganglia with secondary locations in the bone marrow and lymph nodes among others.
Ahrens, Kerstin
core +1 more source
Advanced Science, EarlyView.IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu +8 more
wiley +1 more source
Image4_Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.TIFF [PDF]
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909) +9 more
core +1 more source
Advanced Science, EarlyView.This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang +10 more
wiley +1 more source
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Cell Reports, 2013 The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but few regulators of self-renewal and early cell-fate decisions are known.
Eunjeong Seo +6 more
doaj +1 more source
Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. [PDF]
PLoS ONE, 2012 BACKGROUND: The Hippo pathway regulates organ size by inhibiting cell proliferation and promoting cell apoptosis upon its activation. The Yes Associated Protein 1 (YAP1) is a nuclear effector of the Hippo pathway that promotes cell growth as a ...
Caroline H Diep +7 more
doaj +1 more source
PTPN14 is required for the density-dependent control of YAP1 [PDF]
Genes & Development, 2012 Through an shRNA-mediated loss-of-function screen, we identified PTPN14 as a potential tumor suppressor. PTPN14 interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway. We showed that PTPN14 promotes the nucleus-to-cytoplasm translocation of YAP1 during contact inhibition and thus inhibits YAP1 transactivation activity ...
Wenqi, Wang +7 more
openaire +2 more sources
HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity [PDF]
, 2019 The Hippo pathway is important for tissue homeostasis, regulation of organ size and growth in most tissues. The co‐transcription factor yes‐associated protein 1 (YAP1) serves as a main downstream effector of the Hippo pathway and its dysregulation ...
Davidsen, Johanne +10 more
core +1 more source