Results 71 to 80 of about 23,621 (250)
C-terminal fusion partner activity contributes to the oncogenic functions of YAP1::TFE3
Scientific ReportsYAP1 gene fusions are found in a multitude of human tumors and are the likely tumor-initiating events in these tumors. We have previously shown that YAP1 fusion proteins exert TEAD-dependent oncogenic YAP1 activity.
Patrick J Cimino +4 more
doaj +1 more source
Advanced Science, EarlyView.In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu +12 more
wiley +1 more source
YAP1 und der Hippo Signalweg regulieren Progenitorproliferation
, 2013 1\. Introduction 4 1.1 The Hippo Signaling Pathway 4 1.1.1 The Hippo Signaling Pathway Core Kinase Cascade 5 1.1.2 YAP 8 1.1.3 Downstream Regulators 9 1.1.4 Upstream Regulators 10 1.1.5 The Physiological Role of Mammalian Hippo Signaling 11 1.2 The Skin ...
Schlegelmilch, Karin
core +1 more source
International Journal of Nanomedicine, 2023 Fengmei Chao,1,* Yang Zhang,2,3,* Lei Lv,1 Yaqin Wei,2,3 Xiaoyan Dou,2,3 Na Chang,4 Qiyi Yi,5 Ming Li2,3 1Department of Cancer Epigenetics Program, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of ...
Chao F +7 more
doaj
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Mass spectroscopy analysis of Nuclear YAP1 interacting proteins
, 2023 YAP1 regulates the expression of several genes involved in diverse cell biology, including cell growth, cell survival, cell differentiation, cell transformation, carcinogenesis, and metastasis.
Marwah M. Al-Mathkour +7 more
core +1 more source
Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in
mSphere, 2019 AP-1-like transcription factors play evolutionarily conserved roles as redox sensors in eukaryotic oxidative stress responses. In this study, we aimed to elucidate the regulatory mechanism of an atypical yeast AP-1-like protein, Yap1, in the stress ...
Yee-Seul So +12 more
doaj +1 more source
Atomically precise metal cluster enzymes for pathological tissue regeneration
BMEMat, EarlyView.Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong +11 more
wiley +1 more source
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909) +9 more
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2020 Background Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers.
Qiwen Ben +6 more
doaj +1 more source