Results 91 to 100 of about 23,621 (250)
Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease
iNew Medicine, EarlyView.Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer. It is essential to understand the role of ALD to prevent
Boyu Zhang +5 more
wiley +1 more source
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909) +9 more
core +1 more source
Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress
Interdisciplinary Medicine, EarlyView.This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu +13 more
wiley +1 more source
YAP1 Signaling in Hepatobiliary Development and Oncogenesis
, 2021 Yes-associated protein 1 (YAP1) is critical for liver development, regeneration, and oncogenesis. In this thesis, I studied the physiological role of YAP1 in early liver development, specifically in hepatoblasts as they developed into the major liver ...
Molina, Laura Maria
core
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909) +9 more
core +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee +8 more
wiley +1 more source
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis
Translational NeurodegenerationBackground Aging is the greatest risk factor for late-onset Alzheimer’s disease (LOAD), which accounts for > 95% of all Alzheimer’s disease (AD) cases. Yes-associated protein 1 (YAP1), an aging-dependent protein, is a key element in the classical Hippo ...
Ling Lei +10 more
doaj +1 more source
Yeast, EarlyView.ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley +1 more source
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909) +9 more
core +1 more source
Allergy, EarlyView.Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog +22 more
wiley +1 more source