Results 111 to 120 of about 23,621 (250)

YAP1 induces bladder cancer progression and promotes immune evasion through IL-6/STAT3 pathway and CXCL deregulation

The Journal of Clinical Investigation
The Hippo signaling pathway plays a key role in tumorigenesis in different cancer types. We investigated the role of the Hippo effector YAP1 in the tumor immune microenvironment (TIME) of urothelial carcinoma of the bladder (UCB) and evaluated the ...
Pritam Sadhukhan, Mingxiao Feng, Emily Illingworth, Ido Sloma, Akira Ooki, Andres Matoso, David Sidransky, Burles A. Johnson III, Luigi Marchionni, Fenna C.M. Sillé, Woonyoung Choi, David McConkey, Mohammad O. Hoque   +12 more
doaj   +1 more source

YAP1 promoter-associated noncoding RNA affects Ewing sarcoma cell tumorigenicity by regulating YAP1 expression

Cellular & Molecular Biology Letters
Ewing sarcomas (ESs) are aggressive paediatric tumours of bone and soft tissues afflicting children and adolescents. Despite current therapies having improved the 5-year survival rate to 70% in patients with localized disease, 25% of patients relapse and most have metastasis at diagnosis. Resistance to chemotherapy, together with the high propensity to
Lidia Chellini, Arianna Del Verme, Veronica Riccioni, Maria Paola Paronetto   +3 more
openaire   +3 more sources

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

YAP1 Rearrangement in Parotid Sclerosing Mucoepidermoid Carcinoma

Objective This study investigates to investigate Yes-associated protein 1 (YAP1) rearrangement status in a six-case of sclerosing mucoepidermoid carcinoma (SMEC) series with reference to 20 conventional mucoepidermoid carcinomas.Method A retrospective ...
Sherif Y. El-Nagdy, Bacem Abdullah, Shahram Sabeti, Pushparaja Shetty   +3 more
core   +1 more source

Investigation of YAP1 localisation and dynamics in tumour cell biology [PDF]

, 2019
The complexity of the cancer is created by the fine interplay between cancer cells and their microenvironment. Cancer cells interact with various stromal cell types and extracellular matrix components during tumour growth and development of metastasis ...
Dowbaj, Anna Malgorzata
core  

YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells

, 2007
SummaryThe mechanisms that regulate mammalian organ size are poorly understood. It is unclear whether the pathways that control organ size also impinge on stem/progenitor cells.
Fernando D. Camargo, Dongdong Fu, Gokhale, Sumita, Sumita Gokhale, Bell, George W., George W. Bell, Thijn R. Brummelkamp, Fu, Dongdong, Camargo, Fernando D., Rudolf Jaenisch, Johnnidis, Jonathan B., Brummelkamp, Thijn R., Jaenisch, Rudolf, Jonathan B. Johnnidis   +13 more
core   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling

, 2019
Yes-associated protein (YAP) is a component of the canonical Hippo signaling pathway that is known to play essential roles in modulating organ size, development, and tumorigenesis.
Dong‐E Tang, Lie‐Wen Lin, Xu, Yong, Hong, Xiao-Ping, Hao‐Wu Jiang, Tang, Dong-E, Dong‐Zhou Liu, Song‐Hui Xu, Yong Dai, Liu, Dong-Zhou, Jiang, Hao-Wu, Xu, Song-Hui, Lin, Lie-Wen, Xiao‐Ping Hong, Dai, Yong, Yong Xu   +15 more
core   +1 more source

YAP1/TAZ Mediates Rumen Epithelial Cell Proliferation but Not Short-Chain Fatty Acid Metabolism In Vitro

Animals
Promoting rumen development is closely related to the health and efficient growth of ruminants. The transcriptional co-activators Yes1-associated protein (YAP1) and WW domain-containing transcription regulator protein 1 (TAZ) are key regulators of the ...
Bin Yang, Zebang Xu, Hongwei Chen, Tingting Ma, Yiming Zhao, Mengxin Pang, Jiakun Wang   +6 more
doaj   +1 more source

YAP‐activated lymph node fibroblasts contribute to extracellular matrix remodeling associated with extranodal extension of oral squamous cell carcinoma

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Desmoplasia, characterized by excessive expansion of cancer‐associated fibroblasts (CAFs) and aberrant extracellular matrix (ECM) deposition, is widely present especially in invasive cancers. The extranodal extension (ENE) of nodal metastasis involves the extension of invasive tumor cells through the lymph node capsule into the perinodal ...
Qian Zhang, Shanben Jiang, Ansardin Abliz, Sheng Chen, Qingang Hu, Liang Ding, Yuxin Wang   +6 more
wiley   +1 more source