Results 121 to 130 of about 23,828 (263)
The Journal of Clinical InvestigationThe Hippo signaling pathway plays a key role in tumorigenesis in different cancer types. We investigated the role of the Hippo effector YAP1 in the tumor immune microenvironment (TIME) of urothelial carcinoma of the bladder (UCB) and evaluated the ...
Pritam Sadhukhan +12 more
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Investigation of YAP1 localisation and dynamics in tumour cell biology [PDF]
, 2019 The complexity of the cancer is created by the fine interplay between cancer cells and their microenvironment. Cancer cells interact with various stromal cell types and extracellular matrix components during tumour growth and development of metastasis ...
Dowbaj, Anna Malgorzata
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British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
Cancer Science, EarlyView.We integrated 14 single‐cell RNA‐seq datasets and 18 bulk cohorts to define eight CAF subtypes in GI cancers. myCAF1 and myCAF2 promoted immunosuppressive, poor‐prognosis niches, whereas iCAF1 was linked to favorable prognosis and antitumor immunity.
Huaitao Wang +7 more
wiley +1 more source
Cellular & Molecular Biology LettersEwing sarcomas (ESs) are aggressive paediatric tumours of bone and soft tissues afflicting children and adolescents. Despite current therapies having improved the 5-year survival rate to 70% in patients with localized disease, 25% of patients relapse and most have metastasis at diagnosis. Resistance to chemotherapy, together with the high propensity to
Lidia Chellini +3 more
openaire +3 more sources
New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer
Cancer Science, EarlyView.Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi +2 more
wiley +1 more source
Meningioma: current updates on genetics, classification, and mouse modeling
Upsala Journal of Medical SciencesMeningiomas, the most common primary brain tumors in adults, are often benign and curable by surgical resection. However, a subset is of higher grade, shows aggressive growth behavior as well as brain invasion, and often recurs even after several rounds ...
Frank Szulzewsky +2 more
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Cancer Science, EarlyView.Dietary NA restriction converts the effect of NAMPT inhibition from cytostatic to cytotoxic in SCLC in vivo. ABSTRACT Small‐cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models ...
Kyoji Tsurumi +12 more
wiley +1 more source
Breast Cancer: Targets and Therapy, 2020 Maha Guimei,1,2 Sana Alrouh,3 Maha Saber-Ayad,2– 4 Shirin A Hafezi,3 Arya Vinod,3 Surendra Rawat,3 Yazan Wardeh,5 Tala Mohamad Bakkour,5 Ahmed Taher El-Serafi3,6,7 1Department of Pathology, Faculty of Medicine, Alexandria University, Alexandria ...
Guimei M +8 more
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