Results 141 to 150 of about 23,621 (250)

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

open access: yeseFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu   +6 more
wiley   +1 more source

A novel entity of HIPK2::YAP1 pulmonary fibromatosis

open access: yesBMC Pulmonary Medicine
Abstract Background Pulmonary fibromatosis (PF) is a specific variant of fibromatosis, which is rarely reported occurring in the lung. PF with HIPK2-YAP1 fusion was a novel entity. Case presentation In this report, a 66-year-old male with PF had been smoking over 40 years ...
Yuqiang Liu   +8 more
openaire   +3 more sources

Essential Regulation of YAP1 in Fate Determinations of Spermatogonial Stem Cells and Male Fertility by Interacting with RAD21 and Targeting NEDD4 in Humans and Mice

open access: yesResearch
Spermatogenesis is a sophisticated biological process by which spermatogonial stem cells (SSCs) undergo self-renewal and differentiation into spermatozoa.
Chunyun Li   +6 more
doaj   +1 more source

Collagen III Deficiency Following Injury in Female Murine Tendons Alters Matrix Composition, Structure, Organization and Function

open access: yesJournal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
ABSTRACT Tendons withstand large forces due to an aligned, dense collagen matrix. However, their low cellularity and relative inability to recruit reparative cells post‐injury, coupled with a susceptibility to excessive scarring results in loss of tendon structure and function. Type III collagen (COL3) plays a key role in regulating matrix architecture
J. A. Carlson   +4 more
wiley   +1 more source

Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang   +7 more
wiley   +1 more source

Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells

open access: yesBiology Open, 2023
Martha E. Montané-Romero   +3 more
doaj   +1 more source

Inducible T Cell Costimulator Ligand and Inducible T Cell Costimulator Stratification Identify Dichotomous Tumor Microenvironment and Guide Chemo‐Immunotherapy in Small Cell Lung Cancer

open access: yesMedComm, Volume 7, Issue 6, June 2026.
In small cell lung cancer, high tumor ICOSLG expression drives a microenvironment enriched with immunosuppressive T cells and M2 macrophages. Conversely, ICOSLG low tumors promote CD8+ T cell infiltration. Clinically, high ICOSLG levels predict poor response to immune checkpoint inhibitors and worse survival, whereas low ICOSLG expression indicates ...
Qiji Guo   +9 more
wiley   +1 more source

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