Results 151 to 160 of about 23,828 (263)
Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma
Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinomaPoroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The present study aimed to explore the potential role of gene fusions in the tumorigenesis of poromas. RNA sequencing and reverse transcription PCR identified highly recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poromas (92/104 lesions, 88.5%) and their rare malignant ...
openaire
SRF and YAP1, partners in cardiac repair
The Journal of Cardiovascular Aging, 2022 openaire +2 more sources
Ferroptosis: Newly Emerged Regulator for Human Disease
MedComm, Volume 7, Issue 9, September 2026.Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao +4 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.This prospective study evaluated envafolimab plus chemotherapy in 29 SCLC patients with liver metastases, integrating multi‐omics analyses (WES, RNA‐seq, DNA methylation, ctDNA, and cfDNA methylation). The research framework encompassed granulocyte turnover dynamics, prognostic risk modeling, molecular mechanism exploration across risk strata, and ...
Ning Tang +11 more
wiley +1 more source
Targeting CDK4/6 suppresses colorectal cancer by destabilizing YAP1
MedCommColorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes‐associated protein 1 (YAP1) is frequently dysregulated in cancers, contributing to cancer stemness, chemoresistance, and cancer‐related death.
Yalei Wen +14 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 8, Page 1933-1962, August 2026.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Candida auris YAP1 deléciós mutáns elkészítése [PDF]
A Candida auris a Saccharomycetes osztályba tartozó Ascomycetes élesztőgomba, amely a Clavispora kládhoz tartozik, a többi Candida fajjal együtt. A YAP1 a bZIP transzkripciós faktorok AP-1 alcsaládjába tartozik. Ez a transzkripciós faktor elengedhetetlen
Rácz, Dominika Veronika
core
The Hippo signaling transducers Yap1/Wwtr1 in zebrafish development [PDF]
, 2018 Tissue size regulation is critical for the normal functioning of the organ as well as to prevent unwanted pathogenesis such as cancer. The Hippo signaling pathway is well known for its robust regulation of tissue growth by the negative regulation of its
Lai Kuan Han, Jason
core
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, Volume 13, Issue 43, 3 August 2026.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source