Results 151 to 160 of about 23,621 (250)

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, Volume 2, Issue 2, Page 236-279, June 2026.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

bZIP Transcription Factor PobZIP8 Positively Mediates Heat Stress Tolerance and Negatively Regulates the Growth and Development of Pleurotus ostreatus

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
PobZIP8 from Pleurotus ostreatus enhances heat stress tolerance while negatively regulating fruiting body development, providing a key target for genetic improvement of edible fungi. ABSTRACT Pleurotus ostreatus is a globally cultivated edible and medicinal fungus, but its growth and yield are significantly affected by heat stress during cultivation ...
Yi Zhou, Jinlong Pan, Yuanyuan Zhou, Zihao Li, Hui Zhu, Xiaoxue Liu, Wenqiang Xie, Yajie Zou   +7 more
wiley   +1 more source

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma
Poroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The present study aimed to explore the potential role of gene fusions in the tumorigenesis of poromas. RNA sequencing and reverse transcription PCR identified highly recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poromas (92/104 lesions, 88.5%) and their rare malignant ...
openaire  

Macrophage‐Specific Loss of Stearoyl‐CoA Desaturase 1 Promotes Colon Cancer by Enhancing M2 TAM Polarization

Cancer Science, Volume 117, Issue 6, Page 1566-1579, June 2026.
Macrophage‐specific Scd1 deletion accelerates colon cancer progression by suppressing the Hippo‐YAP pathway, which drives immunosuppressive M2 polarization and induces CD8+ T cell exhaustion. Pharmacological YAP activation with TT‐10 effectively reverses this microenvironment, highlighting a promising target for immunotherapy. ABSTRACT In colon cancer (
Qing You, Jiaqi Du, Ziran Wei, Yandong Liu, Weijun Wang, Wenchao Gao   +5 more
wiley   +1 more source

Targeting CDK4/6 suppresses colorectal cancer by destabilizing YAP1

MedComm
Colorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes‐associated protein 1 (YAP1) is frequently dysregulated in cancers, contributing to cancer stemness, chemoresistance, and cancer‐related death.
Yalei Wen, Xiao Yang, Shengrong Li, Lei Huang, Jiayi Chen, Lirong Tan, Xiuqing Ma, Yingjie Zhu, Zhengqiu Li, Changliang Shan, Chunze Zhang, Qiushi Zhang, Mingchao Liang, Haoxing Zhang, Tongzheng Liu   +14 more
doaj   +1 more source

Liquid‐Form Polycaprolactone Injection Enhances Dermal Thickness and Collagen Production in UVB‐Induced Photoaging Skin

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Skin aging is driven by intrinsic and extrinsic factors, with ultraviolet (UV) radiation recognized as the primary cause of photoaging. Photoaged skin is characterized by reduced dermal thickness and collagen content. Recently, a liquid form of polycaprolactone (PCL) designed to promote uniform scaffold formation within the skin has
Jimyung Seo, Nouren Octresna, Chanjong Lee, Wonkyu Hong, Solam Lee, Meilinah Hidayat, Rudy Haryono, HyunSeok Kim, Teresa Liliana, Sang Ju Lee   +9 more
wiley   +1 more source

Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export

, 2020
The transcriptional regulator YAP1 is critical for the pathological activation of fibroblasts. In normal fibroblasts, YAP1 is located in the cytoplasm, while in activated cancer-associated fibroblasts, it is nuclear and promotes the expression of genes ...
Anna M Dowbaj (9108908), Ming Jiang (11433), Robert P Jenkins (8114663), Nil Ege (9108905), Charles Foster (6310532), Erik Sahai (829065), Michael Howell (228756), Steven Hooper (8307282)   +7 more
core  

Transcriptional Coactivator YAP1 [PDF]

, 2020
openaire   +1 more source

YAP1 wt Allele [PDF]

, 2020
openaire   +1 more source