Results 171 to 180 of about 23,828 (263)

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, Volume 40, Issue 15, August 2026.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source

YAP1 Upregulates Cytoskeleton Regulator ARHGEF1 and Tissue Regeneration Factor NEDD9 in a Multiplex Proteomic Study. [PDF]

Neurol Int
Devadoss D, Akkaoui J, Vashist A, Arias AY, Nefzi A, Lakshmana MK.   +5 more
europepmc   +1 more source

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

GPSM2 Promotes Pancreatic Cancer Progression Through METTL3-Mediated m6A Modification of YAP1 mRNA. [PDF]

J Cell Mol Med
Xiu J, Qiao L, Li M, Hu X, Shen Z, Yang R, Zhang H, Dong Z, Liu X, Zhang Y.   +9 more
europepmc   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

NEDD8 Promotes the Progression and Inflammation of Keratoconus by Increasing the Expression of YAP1. [PDF]

Invest Ophthalmol Vis Sci
Qu J, Zhang X, Wei C, Yu H, Dou S, Gao H.   +5 more
europepmc   +1 more source

Elevated Expression of Selenoprotein Synthesis Enzyme SEPHS2 Driven by ATF4 Promotes the Resistance to Ferroptosis in Prostate Cancer

MedComm, Volume 7, Issue 8, August 2026.
Under the treatment of ferroptosis inducers, the expression of SEPHS2 is upregulated, driven by ATF4, to increase the biosynthesis of selenoproteins (e.g., GPX4) to promote resistance to ferroptosis. ABSTRACT While it has been reported that antioxidant selenoproteins are crucial for anti‐ferroptosis in tumors, it remains unclear whether and how ...
Shijia Bao, Xinxing Du, Zhenkeke Tao, Huixiang Xiao, Jia Zhang, Zhenzhen Wen, Wei‐Qiang Gao, Baijun Dong, Yu‐Xiang Fang, Jianjun Sha   +9 more
wiley   +1 more source

Targeting Rap1-YAP1 mechanosignaling for ameliorating acute IOP elevation-induced trabecular meshwork dysfunction. [PDF]

iScience
Zhang Y, Li X, Hu Q, Luo L, Luo Q, Guan X, Zhu J.   +6 more
europepmc   +1 more source

Ovarian Extracellular Matrix Mechanics Regulate Oocyte‐Follicle Interactions During Female Reproductive Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Hydrogel culture mimicking young and aged ovarian stromal stiffness recapitulates key features of reproductive aging, including impaired follicle growth, transzonal projections (TZPs), and oocyte quality. Silencing Smad7 rescues TZPs and oocyte quality in stiff hydrogels, identifying ECM mechanics as a driver and therapeutic target in ovarian aging ...
Xingyu Shen, Haiyang Wang, Gefei Cao, Yaelim Lee, Jin Zhu, Loo Chien Wang, Tianyun Zhao, Siok Ghee Ler, Radoslaw M. Sobota, Rong Li, Jennifer L. Young   +10 more
wiley   +1 more source

miR-21-5p attenuates hyperoxia-induced lung injury by modulating YAP1-dependent ferroptosis. [PDF]

Front Pharmacol
Huang Q, Yuan P, Liu G, Jia G, Song E, Qin K, Wang Z, Yin F, Chen M.   +8 more
europepmc   +1 more source