Results 181 to 190 of about 23,828 (263)

Application of Systems Genetics to Investigate Molecular Pathology of Early‐Onset Colorectal Cancer

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Early‐onset colorectal cancer (EOCRC) presents a complex molecular landscape that requires integrated multi‐omics approaches. This article reviews current applications of systems genetics in EOCRC research and provides a step‐by‐step protocol for network‐based analyses featuring PIK3CA to demonstrate practical application for researchers of all levels.
Minjae J. Kim, Sydney L. Carr, Vishnutheertha Kulkarni, Mary‐Louise Manchadi   +3 more
wiley   +1 more source

Multidimensional Regulatory Network of <i>YAP1</i> Driving Malignant Progression in Esophageal Cancer: Molecular Mechanisms and Targeted Therapy: A Review. [PDF]

Oncol Res
Chen JH, Du SR, Liu C, Liu BB, Xu HY, Ji XY, Feng B, Ma CZ, Guo JH.   +8 more
europepmc   +1 more source

Physiological and Behavioural Characterisation of a Novel Steroid Sulfatase‐Deficient Mouse

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
STS‐deficient mice are grossly healthy and breed as expected, but are mildly hyperactive and have heavier hearts compared with sex‐matched wildtype controls. ABSTRACT Steroid sulfatase (STS) cleaves sulphate groups from steroid hormones. In humans, STS deficiency is associated with X‐linked ichthyosis, an increased predisposition to neurodevelopmental ...
Trevor Humby, Freya R. Shepherd, Talia Elgie, Libby Anderson‐Watkins, Lucy I. Beevors, Angela E. Taylor, Paul A. Foster, William Davies   +7 more
wiley   +1 more source

Gemcitabine activates the Hippo signaling pathway and suppresses tumor growth by stabilizing large tumor suppressor kinase 2 through the hypoxia-inducible factor 1-alpha/ubiquitin protein ligase E3 component N-recognin 5 axis. [PDF]

J Cell Commun Signal
Zhang J, Xu L, Guo K, Dong W, Dai X, Gu D.   +5 more
europepmc   +1 more source

Poromas with YAP1–MAML2 fusions in a poromatosis case

JAAD Case Reports, 2022
Masako Yamamoto, MD, Yuriko Kawase, MD, PhD, Hirohisa Kishi, MD, PhD, Yuichiro Miyoshi, MD, PhD, Hiroshi Mitsui, MD, PhD, Shigeki Sekine, MD, PhD   +5 more
openaire   +3 more sources

Mechanical Loading Induces Distinct and Shared Responses in Endothelial and Muscle Cells and Reveals Exercise‐Like Molecular Profiles

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Mechanical loading of human endothelial and muscle cells induced several distinct and shared molecular responses, many of which are commonly observed after exercise in vivo. Both cell types secreted acetate and endothelial cells increased serine synthesis from glucose.
Sakari Mäntyselkä, Erik Niemi, Laura Ylä‐Outinen, Kalle Kolari, Liina Uusitalo‐Kylmälä, Alfredo Ortega‐Alonso, Roosa‐Maria Liimatainen, Vasco Fachada, Perttu Permi, Elina Kalenius, Juha J. Hulmi, Riikka Kivelä   +11 more
wiley   +1 more source

Two distinct modes of Vgll4-mediated Tead regulation control organ size in zebrafish. [PDF]

Commun Biol
Lardennois A, Duda V, Dingare C, Klemmt PA, Heinzen C, Desruelles L, Heyde M, Kleinhans DS, Falk T, Schelmbauer C, Mozolewska O, Papadopoulou S, Lai JJK, Stainier DYR, Lecaudey V.   +14 more
europepmc   +1 more source

YAP1 Defines an Emergent, Plastic Population of Relapsed SCLC. [PDF]

J Thorac Oncol
Stewart CA, Ramkumar K, Wang R, Xi Y, Halliday A, Diao L, Wang Q, Serrano A, Groves S, Heeke S, Tanimoto A, Kaiser L, Lewis W, Bose M, Rocha P, Karacosta L, Quaranta V, Wang J, George J, Soto LMS, Zhang B, Heymach JV, Byers LA, Gay CM.   +23 more
europepmc   +1 more source

Luteinizing hormone activates the Hippo pathway to promote progesterone synthesis in bovine luteal cells. [PDF]

Cell Commun Signal
Tamanaeifar F, Owolabi BA, Monaco CF, Moses RM, Castillo AC, Cupp AS, Davis JS, Plewes MR.   +7 more
europepmc   +1 more source

The Hippo signaling pathway in pediatric brain tumors: molecular mechanisms and therapeutic opportunities. [PDF]

Cancer Metastasis Rev
Papanikolaou MA, Gargalionis AN, Adamopoulos C, Piperi C.   +3 more
europepmc   +1 more source