Results 131 to 140 of about 32,177 (245)

Predicting Genetic Regulatory Response Using Classification

, 2004
We present a novel classification-based method for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple organisms such as Saccharomyces cerevisiae, we can learn a decision rule for predicting whether a ...
Freund, Yoav, Kundaje, Anshul, Leslie, Christina, Middendorf, Manuel, Wiggins, Chris   +4 more
core   +4 more sources

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source

Macrophage‐Specific Loss of Stearoyl‐CoA Desaturase 1 Promotes Colon Cancer by Enhancing M2 TAM Polarization

Cancer Science, EarlyView.
Macrophage‐specific Scd1 deletion accelerates colon cancer progression by suppressing the Hippo‐YAP pathway, which drives immunosuppressive M2 polarization and induces CD8+ T cell exhaustion. Pharmacological YAP activation with TT‐10 effectively reverses this microenvironment, highlighting a promising target for immunotherapy. ABSTRACT In colon cancer (
Qing You, Jiaqi Du, Ziran Wei, Yandong Liu, Weijun Wang, Wenchao Gao   +5 more
wiley   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Clinical significance of Yes-associated protein 1 in esophageal squamous cell carcinoma

Zhongguo Linchuang Yixue
ObjectiveTo explore the expression and clinical significance of Yes-associated protein 1 (YAP1) in esophageal squamous cell carcinoma. MethodsImmunohistochemical method was used to detect YAP1 expression in 439 cases of esophageal squamous cell carcinoma.
Kun LIU, Yingying GUAN, Dongxian JIANG, Huijuan XU, Yingyong HOU, Jun HOU   +5 more
doaj   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Maternal vgll4a regulates zebrafish epiboly through Yap1 activity

Frontiers in Cell and Developmental Biology
Gastrulation in zebrafish embryos commences with the morphogenetic rearrangement of blastodermal cells, which undergo a coordinated spreading from the animal pole to wrap around the egg at the vegetal pole. This rearrangement, known as epiboly, relies on the orchestrated activity of maternal transcripts present in the egg, compensating for the gradual ...
Carlos Camacho-Macorra, Carlos Camacho-Macorra, Noemí Tabanera, Noemí Tabanera, Elena Sánchez-Bustamante, Elena Sánchez-Bustamante, Paola Bovolenta, Paola Bovolenta, Marcos J. Cardozo, Marcos J. Cardozo   +9 more
openaire   +3 more sources

miR-21-5p Enriched Exosomes from Human Embryonic Stem Cells Promote Osteogenesis via YAP1 Modulation

International Journal of Nanomedicine
Xinqia Huang,1,* Ziquan Zhao,1,* Weiqiang Zhan,1 Mingzhu Deng,1 Xuyang Wu,1 Zhoutao Chen,1 Jiahao Xie,2 Wei Ye,3 Mingyan Zhao,1,4 Jiaqi Chu3,4 1Orthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001,
Huang X, Zhao Z, Zhan W, Deng M, Wu X, Chen Z, Xie J, Ye W, Zhao M, Chu J   +9 more
doaj  

Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC).

PLoS ONE, 2014
Cigarette smoking is an established risk factor for esophageal cancers. Yes-associated protein 1 (YAP1), the key transcription factor of the mammalian Hippo pathway, has been reported to be an oncogenic factor for many cancers.
Yue Zhao, Wei Zhou, Liyan Xue, Weimin Zhang, Qimin Zhan   +4 more
doaj   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, EarlyView.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source