Results 101 to 110 of about 23,828 (263)

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Decreased expression of miR-132 in CRC tissues and its inhibitory function on tumor progression

Open Life Sciences, 2016
Objectives Colorectal cancer (CRC) is among the most common types of malignancies in the worldwide, and microRNAs (miRNAs) emerge as key regulators in carcinogenesis and tumor progression.
Yong Chen, Xiao-lu Han, Xiao-xiang Yin, Yun Zhou, Tao Wu   +4 more
doaj   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Clinical significance of Yes-associated protein 1 in esophageal squamous cell carcinoma

Zhongguo Linchuang Yixue
ObjectiveTo explore the expression and clinical significance of Yes-associated protein 1 (YAP1) in esophageal squamous cell carcinoma. MethodsImmunohistochemical method was used to detect YAP1 expression in 439 cases of esophageal squamous cell carcinoma.
Kun LIU, Yingying GUAN, Dongxian JIANG, Huijuan XU, Yingyong HOU, Jun HOU   +5 more
doaj   +1 more source

Supplementary Material for: Tumor-intrinsic perinuclear LOXL2: Prognostic relevance and relationship with YAP1 activation status in oral squamous cell carcinoma [Dataset] [PDF]

[Introduction]: Lysyl oxidase-like 2 (LOXL2) expression and function is frequently altered in different cancers but scarcely explored in oral squamous cell carcinoma (OSCC).
Díaz, Eva, Prieto-Fernández, Llara, Lequerica-Fernández, Paloma, Moreno-Bueno, Gema, Rodríguez-Santamarta, Tania, García-Pedrero, Juana M., Rodrigo, Juan P., Vicente, Juan Carlos de, Álvarez-Teijeiro, Saúl   +8 more
core   +1 more source

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation [PDF]

, 2011
SummaryDuring development and regeneration, proliferation of tissue-specific stem cells is tightly controlled to produce organs of a predetermined size. The molecular determinants of this process remain poorly understood.
Joseph Avruch, Jan Pruszak, Thijn R. Brummelkamp, Zhou, Dawang, Dawang Zhou, Renato Rodriguez, Joe, Morvarid Mohseni, Fernando D. Camargo, Schlegelmilch, Karin, J. Renato Rodriguez, Kirak, Oktay, Camargo, Fernando D., Karin Schlegelmilch, Kreger, Bridget T., Rodriguez, J. Renato, Valera Vasioukhin, Vasioukhin, Valera, Oktay Kirak, Pruszak, Jan, Mohseni, Morvarid, Brummelkamp, Thijn R., Bridget T. Kreger, Avruch, Joseph   +22 more
core   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Extracellular Vesicles Derived circSH3PXD2A Inhibits Chemoresistance of Small Cell Lung Cancer by miR-375-3p/YAP1

International Journal of Nanomedicine, 2023
Fengmei Chao,1,* Yang Zhang,2,3,* Lei Lv,1 Yaqin Wei,2,3 Xiaoyan Dou,2,3 Na Chang,4 Qiyi Yi,5 Ming Li2,3 1Department of Cancer Epigenetics Program, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of ...
Chao F, Zhang Y, Lv L, Wei Y, Dou X, Chang N, Yi Q, Li M   +7 more
doaj  

Primary Pulmonary Mesenchymal Neoplasm With EWSR1::CREM Fusion: Cytologic Findings and Molecular Diagnosis

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Primary pulmonary mesenchymal neoplasms with EWSR1::CREM fusion are rare. These lesions are challenging to diagnose by morphology and immunohistochemistry alone. Case A 66‐year‐old woman (ex‐smoker) was found to have a 1.3‐cm right lower lobe lung nodule that had grown very slowly over a 9‐year period.
Priya Upadhyay, Sanjay Mukhopadhyay, Swikrity U. Baskota   +2 more
wiley   +1 more source

Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis

Translational Neurodegeneration
Background Aging is the greatest risk factor for late-onset Alzheimer’s disease (LOAD), which accounts for > 95% of all Alzheimer’s disease (AD) cases. Yes-associated protein 1 (YAP1), an aging-dependent protein, is a key element in the classical Hippo ...
Ling Lei, Yilei Cheng, Anqi Yin, Jian-Min Han, Gang Wu, Fumin Yang, Qi Wang, Jian-Zhi Wang, Rong Liu, Hong-Lian Li, Xiaochuan Wang   +10 more
doaj   +1 more source