Results 81 to 90 of about 23,828 (263)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

PKCι and YAP1 are crucial in promoting pancreatic tumorigenesis [PDF]

Oncotarget, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant disease with 5-year survival rate of less than 6%. Activating mutations of Kras (mu-Kras) are often detected in most of PDAC patients. Although it has been known that oncogenic Kras is the driver of pancreatic cancer initiation and development, the underlying mechanisms by which mu-Kras ...
Wang, Peipei, Wei, Dapeng, Zhang, Hongmei, Chen, Jiao, Zhang, Dingding, Ganapathy, Suthakar, Isakson, Pauline, Chen, Changyan, Zhu, Tongbo   +8 more
openaire   +2 more sources

Image5_Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.TIFF [PDF]

, 2022
Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909), Kienna Matus (11497906), Tadanori Mammoto (72440), Kathryn Hendee (11497903), Sridhar Rao (3534197), Diana M. Tabima (12104945), Akiko Mammoto (148118), Sang H. Lee (7455065), Tendai Hunyenyiwa (11497900), Naomi C. Chesler (12104948)   +9 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension

Cancer Biology & Medicine, 2017
Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Filiz Kisaayak Collak, Ummuhan Demir, Seyma Ozkanli, Esra Kurum, Pinar Engin Zerk   +4 more
doaj   +1 more source

YAP1 protects against septic liver injury via ferroptosis resistance

Cell & Bioscience, 2022
Background The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly emerged form of lytic cell death, has been implicated in sepsis related organ failure.
Jin Wang, Qian Zhu, Rui Li, Jing Zhang, Xujun Ye, Xinyi Li   +5 more
doaj   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Yap1: A DNA damage responder in Saccharomyces cerevisiae [PDF]

Mechanisms of Ageing and Development, 2012
Activation of signaling pathways in response to genotoxic stress is crucial for cells to properly repair DNA damage. In response to DNA damage, intracellular levels of reactive oxygen species increase. One important function of such a response could be to initiate signal transduction processes.
Lori A, Rowe, Natalya, Degtyareva, Paul W, Doetsch   +2 more
openaire   +2 more sources

YAP1 Rearrangement in Parotid Sclerosing Mucoepidermoid Carcinoma [PDF]

Objective This study investigates to investigate Yes-associated protein 1 (YAP1) rearrangement status in a six-case of sclerosing mucoepidermoid carcinoma (SMEC) series with reference to 20 conventional mucoepidermoid carcinomas.Method A retrospective ...
Sherif Y. El-Nagdy, Bacem Abdullah, Shahram Sabeti, Pushparaja Shetty   +3 more
core   +1 more source

YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells [PDF]

, 2007
SummaryThe mechanisms that regulate mammalian organ size are poorly understood. It is unclear whether the pathways that control organ size also impinge on stem/progenitor cells.
Fernando D. Camargo, Dongdong Fu, Gokhale, Sumita, Sumita Gokhale, Bell, George W., George W. Bell, Thijn R. Brummelkamp, Fu, Dongdong, Camargo, Fernando D., Rudolf Jaenisch, Johnnidis, Jonathan B., Brummelkamp, Thijn R., Jaenisch, Rudolf, Jonathan B. Johnnidis   +13 more
core   +1 more source