Molecular & Cellular Oncology, 2019 Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce ...
Cheng Wang, John S Davis
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Yap1 is required for maintenance of adult RPE differentiation [PDF]
The FASEB Journal, 2020 Abstract Nuclear YAP1 plays a critical role in regulation of stem cell proliferation, tissue regeneration, and organ size in many types of epithelia. Due to rapid turnover of most epithelial cell types, the cytoplasmic function of YAP1 in epithelial cells has not been well studied.
Qingxian, Lu +5 more
openaire +2 more sources
Altered microRNA expression profiles in large offspring syndrome and Beckwith-Wiedemann syndrome
Epigenetics, 2019 The use of assisted reproductive technologies (ART) can induce a congenital overgrowth condition in humans and ruminants, namely Beckwith-Wiedemann syndrome (BWS) and large offspring syndrome (LOS), respectively.
Yahan Li +7 more
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YAP1 und der Hippo Signalweg regulieren Progenitorproliferation [PDF]
, 2013 1\. Introduction 4 1.1 The Hippo Signaling Pathway 4 1.1.1 The Hippo Signaling Pathway Core Kinase Cascade 5 1.1.2 YAP 8 1.1.3 Downstream Regulators 9 1.1.4 Upstream Regulators 10 1.1.5 The Physiological Role of Mammalian Hippo Signaling 11 1.2 The Skin ...
Schlegelmilch, Karin
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New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression [PDF]
Iranian Journal of Colorectal Research, 2019 Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers.
Fariba Dehghanian +3 more
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Mass spectroscopy analysis of Nuclear YAP1 interacting proteins [PDF]
, 2023 YAP1 regulates the expression of several genes involved in diverse cell biology, including cell growth, cell survival, cell differentiation, cell transformation, carcinogenesis, and metastasis.
Marwah M. Al-Mathkour +7 more
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DataSheet3_Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.PDF [PDF]
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909) +9 more
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miR-375 Inhibits Proliferation of Mouse Pancreatic Progenitor Cells by Targeting YAP1
Cellular Physiology and Biochemistry, 2013 Background/Aims: The Hippo signaling pathway regulates expansion and differentiation of stem cells and tissue progenitor cells during organ development and tissue regeneration.
Zhen-Wu Zhang +5 more
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Image3_Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.TIFF [PDF]
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Priscilla Kyi (11497909) +9 more
core +1 more source
Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer
Molecular & Cellular Oncology, 2021 In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in ...
Amanda K. Riley, Alice H. Berger
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