Results 41 to 50 of about 23,621 (250)
Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
Cell Reports, 2022 Summary: Inactivation of Capicua (CIC) or upregulation of yes-associated protein 1, YAP1, leads to broad RAS-RAF-MEK-ERK inhibitor resistance and tumor progression in multiple human cancers.
Ji Won Kim +6 more
doaj +1 more source
YAP1 is essential for malignant mesothelioma tumor maintenance
BMC Cancer, 2022 AbstractMalignant pleural mesothelioma, a tumor arising from the membrane covering the lungs and the inner side of the ribs, is a cancer in which genetic alterations of genes encoding proteins that act on or are part of the Hippo-YAP1 signaling pathway are frequent.
Loreley Calvet +14 more
openaire +3 more sources
Yap1 regulates dendritic tree complexity.
, 2019 (A) Efficacy of Yap1 shRNA in neurons, analyzed by western blot. (B) Rat hippocampal neurons were transfected on DIV7 with the indicated constructs. An empty pLKO plasmid was used as the control. (C, D) Quantification of TDL (C) and Sholl analysis (D) of
Hubert Doleżyczek (6654860) +9 more
core +1 more source
Molecular & Cellular Oncology, 2019 Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce ...
Cheng Wang, John S Davis
doaj +1 more source
Genes & Development, 2022 YAP1 is a transcriptional coactivator regulated by the Hippo signaling pathway, including NF2. Meningiomas are the most common primary brain tumors; a large percentage exhibit heterozygous loss of chromosome 22 (harboring the NF2 gene) and functional inactivation of the remaining NF2 copy, implicating oncogenic YAP activity in these tumors.
Frank Szulzewsky +9 more
openaire +2 more sources
Altered microRNA expression profiles in large offspring syndrome and Beckwith-Wiedemann syndrome
Epigenetics, 2019 The use of assisted reproductive technologies (ART) can induce a congenital overgrowth condition in humans and ruminants, namely Beckwith-Wiedemann syndrome (BWS) and large offspring syndrome (LOS), respectively.
Yahan Li +7 more
doaj +1 more source
Effect of YAP1 silencing on esophageal cancer
OncoTargets and Therapy, 2016 YAP1, the nuclear effector of the Hippo pathway, has become an attractive target for treatment of malignancies and is a candidate oncogene in esophageal cancer (EC). We hypothesized that knockdown of YAP1 could suppress EC and could be used for targeted therapy. However, there are few reports of the effect of YAP1 knockdown in EC.Quantitative real-time
Zhao,Jia +7 more
openaire +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration [PDF]
, 2022 Pulmonary artery (PA) pressure increases during lung growth after unilateral pneumonectomy (PNX). Mechanosensitive transcriptional co-activator, yes-associated protein (YAP1), in endothelial cells (ECs) is necessary for angiogenesis during post-PNX lung ...
Chesler, Naomi C +9 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source