Results 21 to 30 of about 23,828 (263)
YAP1 Meets Tumor Suppression [PDF]
Molecular Cell, 2007 In this issue of Molecular Cell, Matallanas et al. (2007) demonstrate that RASSF1A-induced apoptosis impinges on the transcriptional coactivator YAP1, whose nuclear translocation and binding to p73 result in proper execution of the cell death pathway. Indeed, RASSF1A silencing in tumors inhibits YAP1-p73-dependent apoptosis.
Strano, Sabrina, Blandino, Giovanni
openaire +2 more sources
YAP1/TAZ drives ependymoma-like tumour formation in mice [PDF]
, 2020 YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to ...
Marie-Charlotte Dolmart (8848991) +14 more
core +6 more sources
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers. [PDF]
PLoS Genetics, 2015 YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers.
Claudia Stein +10 more
doaj +1 more source
Nucleo-cytoplasmic distribution of YAP1. [PDF]
, 2022 (A) Immunofluorescence staining of YAP1 together with DAPI and occludin-mEmerald. Static control above and compressed sample below. Scale bars 30 μm. (B) Nucleo-cytoplasmic ratio of YAP1 signal in static controls and compressed samples. P-value < 0.0001 (
Pasi Kallio (3412838) +6 more
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PSME4 Degrades Acetylated YAP1 in the Nucleus of Mesenchymal Stem Cells
Pharmaceutics, 2022 Intensive research has focused on minimizing the infarct area and stimulating endogenous regeneration after myocardial infarction. Our group previously elucidated that apicidin, a histone deacetylase (HDAC) inhibitor, robustly accelerates the cardiac ...
Yong Sook Kim +10 more
doaj +1 more source
Cancer Communications, 2023 Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear.
Yan Guo +11 more
doaj +1 more source
Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion [PDF]
, 2014 Oxidative folding of secretory proteins in the endoplasmic reticulum (ER) is a redox active process, which also impacts the redox conditions in the cytosol. As the transcription factor Yap1 is involved in the transcriptional response to oxidative stress,
Stephan Hann +6 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2021 Increased expression of Yes-associated protein-1 (YAP1) was shown to correlate with reduced survival in breast cancer (BC) patients. However, the exact mechanism of YAP1 regulation in BC cells remains ambiguous.
Jibran Sualeh Muhammad +9 more
doaj +1 more source
The feedback loop of ANKHD1/lncRNA MALAT1/YAP1 strengthens the radioresistance of CRC by activating YAP1/AKT signaling [PDF]
Cell Death & Disease, 2022 AbstractInnate radioresistance substantially limits the effectiveness of radiotherapy for colorectal cancer (CRC); thus, a strategy to enhance the radiosensitivity of CRC is urgently needed. Herein, we reported that ankyrin repeat and KH domain containing 1 (ANKHD1) serves as a key regulator of radioresistance in CRC. ANKHD1 was highly expressed in CRC
Ping-an Yao +5 more
openaire +3 more sources
YAP1/TEAD1 target genes. [PDF]
, 2015 (A) Gene expression of target genes from all, proximal (≤2Kb), distal (>2Kb) or random YAP1/TEAD1 peaks. Peaks were assigned to their closest gene TSS.
Anaïs Flore Bardet (785780) +10 more
core +1 more source