Results 171 to 180 of about 67,151 (262)
Role of the Hippo pathway in autoimmune diseases
Experimental GerontologyThe immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play ...
Hui Kong +3 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Targeting the Hippo Pathway for Cardiac Regeneration
PhysiologyIschemic heart disease, which affects more than 200 million people worldwide, is caused by reduced blood flow to the heart and leads to widespread cardiomyocyte death. Due to the limited regenerative potential of cardiomyocytes, the lost tissue is replaced by a fibrotic scar, resulting in reduced cardiac function and progression to heart failure ...
Rich Gang Li +2 more
openaire +2 more sources
Molecular Carcinogenesis, EarlyView.ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha +26 more
wiley +1 more source
Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension. [PDF]
, 2017 Objective:Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Collak, Filiz Kisaayak +4 more
core
Medicinal Research Reviews, EarlyView.ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He +2 more
wiley +1 more source
SnapShot: The Hippo Signaling Pathway
Cell, 2011 Badouel, Caroline, McNeill, Helen
openaire +2 more sources
More than proteins for empty stomachs: Wild meat in the BaTonga food system
People and Nature, EarlyView.Abstract Our paper highlights the limitations of the framework used by many conservation‐focused programmes that incorporate food security objectives. This framework encourages the substitution of wild proteins with domestic proteins by promoting animal farming in communities located near conservation areas.
Muriel Figuié +5 more
wiley +1 more source
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source