Results 71 to 80 of about 41,234 (255)

Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean‐François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis   +8 more
wiley   +1 more source

Hippocampal Sclerosis and Cognitive Dysfunction

Pediatric Neurology Briefs, 1997
Deficits of cognitive function, including language development and learning of complex social skills, typical of mental deficiency and autism, are reported in 4 children with bilateral hippocampal sclerosis and epilepsy followed at Duke University ...
J Gordon Millichap
doaj   +1 more source

Distinct thalamic functional connectivity and volume patterns across focal epilepsies in children: A multimodal neuroimaging study

Epilepsia, EarlyView.
Abstract Objective The thalamus is a key hub in seizure propagation, and its nuclei are emerging targets for neuromodulation. However, the contributions of individual nuclei to epileptic networks remain unclear, particularly in children, who are less studied than adults.
Xiyu Feng, Aswin Chari, Maria H. Eriksson, Freya Prentice, Xiaosong He, Hua Xie, Leigh Sepeta, M. Zubair Tahir, Jonathan D. Clayden, Martin M. Tisdall, Torsten Baldeweg, Rory J. Piper   +11 more
wiley   +1 more source

Hippocampal sclerosis affects fMR-adaptation of lyrics and melodies in songs

Frontiers in Human Neuroscience, 2014
Songs constitute a natural combination of lyrics and melodies, but it is unclear whether and how these two song components are integrated during the emergence of a memory trace.
Irene eAlonso, Irene eAlonso, Irene eAlonso, Irene eAlonso, Daniela eSammler, Daniela eSammler, Daniela eSammler, Daniela eSammler, Romain eValabrègue, Romain eValabrègue, Vera eDinkelacker, Vera eDinkelacker, Sophie eDupont, Sophie eDupont, Pascal eBelin, Pascal eBelin, Pascal eBelin, Séverine eSamson, Séverine eSamson   +18 more
doaj   +1 more source

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source

Hippocampal Sclerosis in Identical Twins

Pediatric Neurology Briefs, 1998
The genetic and acquired hypotheses of etiology of hippocampal sclerosis (HS) were studied at the University of Melbourne, Australia, using quantitative MRI in three monozygous (MZ) twin pairs, only the index twin having temporal lobe epilepsy and HS.
J Gordon Millichap
doaj   +1 more source

Amygdala enlargement associated with remote epileptogenic lesions

Epilepsia, EarlyView.
Abstract Objective To determine the prevalence and possible causes of amygdala enlargement in patients with drug‐resistant temporal lobe epilepsy. Methods Patients were retrospectively identified via a radiology information system and a large language model.
Horst Urbach, Theo Demerath, Alexander Rau, Dirk‐Matthias Altenmüller, Marcel Heers, Samer Elsheikh   +5 more
wiley   +1 more source

Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration

Dementia & Neuropsychologia
Objective: To describe characteristics of hippocampal sclerosis dementia. Methods: Convenience sample of Hippocampal sclerosis dementia (HSD) recruited from the Johns Hopkins University Brain Resource Center.
Chiadi U. Onyike, Olga Pletnikova, Kelly L. Sloane, Campbell Sullivan, Juan C. Troncoso, Peter V. Rabins   +5 more
doaj   +1 more source

Temporal Lobectomy for Epilepsy with Congenital Porencephaly and Hippocampal Sclerosis

Pediatric Neurology Briefs, 2003
The clinical characteristics and surgical outcome of 6 patients with intractable epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis are presented from the University of Alabama, Birmingham, AL.
J Gordon Millichap
doaj   +1 more source

Dynamic patterns of verbal memory function after an initial decline following temporal lobe resection against epilepsy: Sex‐specific differences in the postoperative course

Epilepsia, EarlyView.
Abstract Objective This study was performed to investigate the postoperative dynamics of verbal memory function after temporal lobe resection (TLR) in people with temporal lobe epilepsy (PwTLE), with a specific focus on the course following an initial verbal memory decline and the factors influencing later changes.
Pia Langenberg, Lea M. Reisch, Johanna L. Hopf, Florian J. Mücke, Lea Wemheuer, Christian G. Bien, Philip Grewe   +6 more
wiley   +1 more source