Results 101 to 110 of about 633,597 (336)

Short-term dynamics of input and output of CA1 network greatly differ between the dorsal and ventral rat hippocampus

open access: yesBMC Neuroscience, 2019
Background The functional heterogeneity of the hippocampus along its longitudinal axis at the level of behavior is an established concept; however, the neurobiological mechanisms are still unknown.
Andriana Koutsoumpa   +1 more
doaj   +1 more source

Transcriptional and translational differences of microglia from male and female brains [PDF]

open access: yes, 2019
Sex differences in brain structure and function are of substantial scientific interest because of sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a common denominator of many of these diseases and thus microglia
Güneykaya, Dilansu
core   +1 more source

Prediction, sequences and the hippocampus [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2009
Recordings of rat hippocampal place cells have provided information about how the hippocampus retrieves memory sequences. One line of evidence has to do with phase precession, a process organized by theta and gamma oscillations. This precession can be interpreted as the cued prediction of the sequence of upcoming positions.
John E. Lisman, A.D. Redish
openaire   +3 more sources

Facile Deep Brain Electrode Coating with MXene for Improved Electrode Performance

open access: yesAdvanced Healthcare Materials, EarlyView.
Facile dip‐coating of commercial carbon fiber electrodes with Ti3C2Tx MXene improves electrical conductivity, reduces impedance, and enables single‐neuron recordings in the rat hippocampus over four weeks. The coating maintains biocompatibility, minimizes inflammation, and remains MRI‐compatible.
Laura Kondrataviciute   +5 more
wiley   +1 more source

Gestational diabetes induces neuronal loss in dentate gyrus in rat offspring [PDF]

open access: yes, 2014
Background: This study was conducted to determine the effect of gestational diabetes on neuronal density in the dentate gyrus (DG) subfields of hippocampus in rats offspring. Methods: On day 1 of gestation, 10 dams randomly allocated into two control and
Ghafari, S.   +2 more
core  

Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. [PDF]

open access: yes, 2014
While the hippocampus has been classically studied for its role in learning and memory, there is significant support for a role of the HPC in regulating emotional behavior.
Jimenez, Jessica C   +2 more
core   +2 more sources

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

open access: yesAdvanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li   +8 more
wiley   +1 more source

A gradient of frequency-dependent synaptic properties along the longitudinal hippocampal axis

open access: yesBMC Neuroscience, 2017
Background The hippocampus is a functionally heterogeneous brain structure and specializations of the intrinsic neuronal network may crucially support the functional segregation along the longitudinal axis of the hippocampus.
Vassilios Papaleonidopoulos   +3 more
doaj   +1 more source

Solving the detour problem in navigation: a model of prefrontal and hippocampal interactions. [PDF]

open access: yes, 2015
Adapting behavior to accommodate changes in the environment is an important function of the nervous system. A universal problem for motile animals is the discovery that a learned route is blocked and a detour is required.
Gilbert, SJ, Spiers, HJ
core   +2 more sources

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

open access: yesAdvanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

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