Results 191 to 200 of about 633,597 (336)

LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies. [PDF]

open access: yesActa Neuropathol
Buck SA   +11 more
europepmc   +1 more source

Ventral Hippocampus Spikes During Sleep, Wakefulness, and Arousal in the Cat

open access: bronze, 1978
Kristyna M. Hartse   +3 more
openalex   +1 more source

An Automated Micro‐Immunobeads‐Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This work presents an automated and accessible point‐of‐care device, MEMOs, for the detection of exosomal Aβ42 protein, a potential blood biomarker for Alzheimer’s disease. MEMOs, with its automated operation workflow, minimizes hands‐on time and maintains high sensitivity in diagnosing AD, allowing non‐specialists to conduct tests at home and offering
Xiaoxue Fan   +10 more
wiley   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

open access: yesAdvanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang   +21 more
wiley   +1 more source

Brain structural and functional aberrant of hippocampal subregions was associated with somatic depression. [PDF]

open access: yesBMC Psychiatry
Juan Q   +7 more
europepmc   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

open access: yesAdvanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang   +19 more
wiley   +1 more source

TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus. [PDF]

open access: yesTransl Psychiatry
Chen X   +11 more
europepmc   +1 more source

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