Results 11 to 20 of about 3,676 (204)

Spontaneous electrical activity and behavior in the leech hirudo medicinalis. [PDF]

Front Integr Neurosci, 2007
In the absence of external stimuli, animals explore the environment by performing irregular movements, but the neuronal mechanisms underlying this arrhythmic motion are largely unknown.
Garcia-Perez E, Mazzoni A, Torre V.
europepmc   +2 more sources

Microsurgeon Hirudo medicinalis as a Natural Bioshuttle for Spontaneous Mass Vaccination against Influenza A Virus. [PDF]

Bioimpacts, 2011
Introduction: Recent report on existence of a stem region of hemagglutinin has arisen new hopes for vaccination of influenza A as it consist of a conserve fusion peptide shared across several influenza subtypes and can be targeted by human immune system.
Samadi-Shams S, Atashpaz S, Khani S.
europepmc   +2 more sources

Predictive Distribution Modeling of the Medicinal Leech <i>Hirudo verbana</i> Carena, 1820 (Hirudinea, Hirudinidae) in Sicily: Implications for Conservation. [PDF]

Ecol Evol
A predictive distribution model for Hirudo verbana in Sicily was developed using 1980–2024 occurrence data and environmental variables. The species is associated with densely vegetated, high‐elevation lentic habitats and avoids human‐disturbed areas.
Liuzzo M, Utevsky S, Marrone F.
europepmc   +2 more sources

Unravelling the Extent of Diversity within the Iberian Medicinal Leeches (Hirudinea: Hirudo) Using Molecules and Morphology

Biology, 2021
Until the beginning of the 21st century, the famous medicinal leech was thought to be represented by only one species, Hirudo medicinalis. However, recent publications have demonstrated that under that name, at least five different species of medicinal ...
Andrés Arias, Victor Surugiu, Rafael Carballeira, Oana Paula Popa, Luis Ovidiu Popa, Serge Utevsky   +5 more
doaj   +1 more source

From haemadin to haemanorm: Synthesis and characterization of full‐length haemadin from the leech Haemadipsa sylvestris and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)

Protein Science, Volume 32, Issue 12, December 2023., 2023
Abstract Hirudin from Hirudo medicinalis is a bivalent α‐Thrombin (αT) inhibitor, targeting the enzyme active site and exosite‐I, and is currently used in anticoagulant therapy along with its simplified analogue hirulog. Haemadin, a small protein (57 amino acids) isolated from the land‐living leech Haemadipsa sylvestris, selectively inhibits αT with a ...
Laura Acquasaliente, Andrea Pierangelini, Anna Pagotto, Nicola Pozzi, Vincenzo De Filippis   +4 more
wiley   +1 more source

Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease

Microbial Biotechnology, Volume 16, Issue 10, Page 1940-1956, October 2023., 2023
Workflow for the comprehensive exploration of IM dysbiosis in edema Whitmania pigra. Abstract Whitmania pigra is widely used in traditional Chinese medicine. However, W. pigra is being threatened by an edema disease with unknown causes (WPE). In this study, a comprehensive exploration of virome, microbiome, and metabolome aberrations in the intestine ...
Caijiao Dai, Xin Chen, Shiyu Qian, Yihui Fan, Lijuan Li, Junfa Yuan   +5 more
wiley   +1 more source

Hirudin inhibits glioma growth through mTOR‐regulated autophagy

Journal of Cellular and Molecular Medicine, Volume 27, Issue 18, Page 2701-2713, September 2023., 2023
Abstract Glioma is the most common primary malignant brain tumour, and survival is poor. Hirudin has anticancer pharmacological effects through suppression of glioma cell progression, but the molecular target and mechanism are poorly understood. In this study, we observed that hirudin dose‐ and time‐dependently inhibited glioma invasion, migration and ...
Ying Ma, Senbin Wu, Fanyi Zhao, Huifeng Li, Qiaohong Li, Jingzhi Zhang, Hua Li, Zhongmin Yuan   +7 more
wiley   +1 more source

Occurrence, distribution and bibliography of the medicinal leech Hirudo verbana Carena, 1820 (Hirudinea, Hirudinidae) in Sicily (Italy) [PDF]

, 2019
The occurrence of the medicinal leech Hirudo verbana in the inland waters of Sicily has been lately overlooked. In the present note, the occurrence and distribution of this species is reviewed based both on the review of the available literature data and
Canale D. E., Marrone F.
core   +2 more sources

Interaction between nanomaterials and the innate immune system across evolution

Biological Reviews, Volume 98, Issue 3, Page 747-774, June 2023., 2023
ABSTRACT Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with cells and molecules of innate immunity, which are present in interface tissues of living organisms. Immuno‐nanotoxicological studies aim at understanding if and when such interaction is inconsequential or may cause irreparable damage. Since innate immunity
Diana Boraschi, Laura Canesi, Damjana Drobne, Birgit Kemmerling, Annalisa Pinsino, Petra Prochazkova   +5 more
wiley   +1 more source

A Biologically Interfaced Evolvable Organic Pattern Classifier

Advanced Science, Volume 10, Issue 14, May 17, 2023., 2023
A modular circuit constructed mainly of organic electrochemical transistors is used to classify patterns written on a 4 × 4 pixel array, translate a positive classification to a signal that is interpretable by biological systems, and interface with the ventral nerve cord of a medicinal leech to actuate muscle contraction upon encountering a positive ...
Jennifer Y. Gerasimov, Deyu Tu, Vivek Hitaishi, Padinhare Cholakkal Harikesh, Chi‐Yuan Yang, Tobias Abrahamsson, Meysam Rad, Mary J. Donahue, Malin Silverå Ejneby, Magnus Berggren, Robert Forchheimer, Simone Fabiano   +11 more
wiley   +1 more source