Results 171 to 180 of about 26,153 (259)

Identification of diagnostic biomarkers for neonatal necrotizing enterocolitis via machine learning screening and single‐cell virtual gene knockout validation

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Integrated machine learning screening of five gene expression omnibus datasets and 113 algorithm combinations identified three candidate diagnostic biomarkers for neonatal necrotizing enterocolitis: SLC26A3 (downregulated), CCL20, and CXCL5 (both upregulated). Single‐cell RNA sequencing localized CCL20 upregulation predominantly to macrophages.
Xue Liu, Wenqiang Sun, Zengxue Hu, Yihui Li, Jingtao Bian, Xueping Zhu   +5 more
wiley   +1 more source

Proton Pump Inhibitors and Histamine-2 Receptor Antagonists in Spinal Fusion: A Systematic Review. [PDF]

Global Spine J
Frappa N, Chernov D, Alben MG, Dillon M, Papalia AG, Riley R, Troiani Z, Lucasti C.   +7 more
europepmc   +1 more source

Temporal Patterns of Allergen Sensitisation in the General Population: The LEAD Study

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Background Allergic sensitisation is traditionally viewed as a stable trait despite studies suggesting that it may vary across life‐course. This study aims to provide longitudinal evidence of allergic sensitisation and its associated factors in the general population.
Charmaine J. M. Lim, Abdelrahman Omar, Severin Pötscher, Marie‐Kathrin Breyer, Frits M. E. Franssen, Emiel F. M. Wouters, Robab Breyer‐Kohansal   +6 more
wiley   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +1 more source

Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
For acute ischemic stroke due to large vessel occlusion, adjunctive neuroprotective therapy with mechanical thrombectomy is important; however, current treatment options are relatively limited. Phenothiazines such as chlorpromazine and promethazine (C + P) have shown potential neuroprotective effects in preclinical studies.
Qi Wang, Weili Li, Di Wu, Shuaili Xu, Xunming Ji   +4 more
wiley   +1 more source

Irritable Bowel Syndrome Clinical Care Gaps and the Potential of Future Therapeutics Based on Peripheral Visceral Afferent Modulation. [PDF]

Clin Gastroenterol Hepatol
Camilleri M.
europepmc   +1 more source

Effect of C5a Receptor Antagonist on the Osteogenic Differentiation of Dental Pulp Stem Cells

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objective Complement component 5a (C5a) binding to its receptor (C5aR) can mediate pro‐inflammatory immune responses, which impairs osteogenic differentiation of dental pulp stem cells (DPSCs). The present study aimed to evaluate the regulatory effect of C5aR antagonist (W54011) on the osteogenic differentiation of DPSCs in an in vitro ...
Xiaohan Tan, Junlong Hu, Junhui Li, Zhuangying Chen, Xin Shi, Jie Liu, Mingyue Liu, Weiping Hu   +7 more
wiley   +1 more source

Mirtazapine is a functional antagonist at cardiac human H₁-histamine receptors. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Pham TH, Schlicht JMA, Hofmann B, Kirchhefer U, Neumann J, Gergs U.   +5 more
europepmc   +1 more source

Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects

Future Postharvest and Food, Volume 3, Issue 2, Page 142-162, June 2026.
ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq, Sajad Ahmad Mir, Zahida Naseem   +2 more
wiley   +1 more source

Cytotoxic effect of famotidine in breast adenocarcinoma cells line. [PDF]

North Clin Istanb
Kaskal M, Kinikoglu O, Zelhof G, Bilir EK.   +3 more
europepmc   +1 more source