Results 181 to 190 of about 167,267 (301)

Optimising Asparaginase Use and Managing Hypersensitivity in Australasia—A Clinical Practice Guideline From the Australian and New Zealand Children's Haematology/Oncology Group

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Asparaginase is a critical component of modern multi‐agent chemotherapy regimens for paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma, with inadequate exposure leading to inferior patient outcomes. Objectives To develop a clinical practice guideline for the use of asparaginase products in the Australasian context.
Matthew J. O'Connor, Michelle Martin, Sarah M. Trinder, Draga Barbaric, Diane Hanna, Chow Y. Lai, Michael P. Osborn, Tim Prestige, Bryony Ross, Leanne Super, Thomas Walwyn, Stacie S. Wang, Andrew Wood, Andrew S. Moore, Rishi S. Kotecha, Siobhan Cross   +15 more
wiley   +1 more source

Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities. [PDF]

Acta Pharm Sin B
Wu T, Zhang Y, Han J.
europepmc   +1 more source

Use of Platelet‐Rich Fibrin (PRF) on Palatal Wound Healing: A Narrative Review With Clinical Recommendations

Journal of Periodontal Research, EarlyView.
Based on the available evidence, the application of platelet‐rich fibrin (PRF) following free gingival graft (FGG) and subepithelial connective tissue graft (SCTG) harvesting appears to be a promising approach for enhancing wound healing, minimizing postoperative complications, and reducing analgesic consumption. ABSTRACT This clinical narrative review
Nima Farshidfar, Paras Ahmad, Nathan Estrin, Yufeng Zhang, Richard J. Miron   +4 more
wiley   +1 more source

Association between the incidence of infusion-related reactions by obinutuzumab and the dose of corticosteroid as premedication: a multicenter retrospective cohort study. [PDF]

J Pharm Health Care Sci
Ohtsubo T, Yamamoto K, Matumoto S, Ito K, Sasa Y, Tomishima K, Dote S, Makihara K, Wakasugi Y, Mitsuie T, Yamagiwa K, Sato K, Hasegawa H, Uoshima N, Kitahiro Y, Tomogane K.   +15 more
europepmc   +1 more source

GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways

Clinical &Experimental Allergy, EarlyView.
M. Niemi, S. Ruotsalainen, E. Saarentaus, I. Vähätalo, F. FinnGen, I. Starskaia, T. Harju, M. Pelkonen, T. Feuth, P. Kauppi, J. Partanen, R. Lahesmaa, V. Hytönen, A. Palotie, H. Kankaanranta, T. Laitinen   +15 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Elevated Histamine Receptor 2 and Toll-Like Receptor 7 Expression in Rheumatoid Arthritis: Insights Into Inflammatory Mechanisms and Potential Therapeutic Strategies. [PDF]

Int J Rheum Dis
Kamil Al-Basri A, Sedighi S, Bagheri Y, Saghaiyan Jazi M, Heydari E, Azimi H, Davoodi H.   +6 more
europepmc   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Redox-sensitive GPCR signaling drives Gq-dependent Ca²⁺ mobilization and cytokine production in human bronchial epithelial cells. [PDF]

Am J Physiol Cell Physiol
Lapiro J, Srisomboon Y, Law K, O'Grady SM.   +3 more
europepmc   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source