Results 241 to 250 of about 52,048 (339)

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, Volume 183, Issue 9, Page 2009-2027, May 2026.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists

, 2013
David M. Wilson, James Apps, Nicholas Bailey, Mark J. Bamford, I.J.M. Beresford, Kim Brackenborough, Michael A. Briggs, Stephen Brough, Andrew R. Calver, Barry Crook, Rebecca K. Davis, Robert P. Davis, Susannah Davis, David K. Dean, Leanne Harris, Teresa Heslop, Vicky Holland, Phillip Jeffrey, Terrance A. Panchal, Christopher A. Parr, Nigel Quashie, Joanne Schogger, Sanjeet S. Sehmi, Tania O. Stean, Jon G.A. Steadman, Brenda Trail, Jeffrey Wald, Angela Worby, Andrew K. Takle, Jason Witherington, Andrew D. Medhurst   +30 more
openalex   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, Volume 183, Issue 9, Page 2099-2122, May 2026.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

The neuro-immune insights of itch: peripheral mechanisms and central glial contributions. [PDF]

Cell Mol Biol Lett
Li Z, Yu N, Feng S, Wang X, Chu YX, Liu X.   +5 more
europepmc   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, Volume 183, Issue 9, Page 2049-2060, May 2026.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Restless Legs Syndrome Associated With Fexofenadine Use: A Case Report. [PDF]

Clin Case Rep
Albeshry AM.
europepmc   +1 more source

Novel Carbamates as Potent Histamine H₃Receptor Antagonists with Highin Vitroand Oralin VivoActivity^,

, 1996
Holger Stark, Katja Purand, Xavier Ligneau, A. Rouleau, Jean‐Michel Arrang, M. Garbarg, Jean‐Charles Schwartz, Walter Schunack   +7 more
openalex   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Cardiovascular manifestations in mast cell activation disease: key insights for cardiologists and angiologists. [PDF]

Front Cardiovasc Med
Taumann W, Molderings GJ.
europepmc   +1 more source

Effects of thioperamide, an antagonist of histamine H3-receptor, on monoamine levels and monoamine oxidase activity in rat brain.

, 1993
Eiichi Sakurai, Eiko Sakurai, Kazutaka Maeyama, Takehiko Watanabe, Lars Oreland   +4 more
openalex   +1 more source