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Histamine-2 Receptor Antagonists as Immunomodulators: New Therapeutic Views?
Annals of Medicine, 1996 Considerable evidence has emerged to suggest that histamine participates in the regulation of the inflammatory response, immune reaction, coagulation cascade, and cardiovascular function.
Hans Jørgen Nielsen, H J Nielsen
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ACS Medicinal Chemistry Letters, 2015 The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H3 receptor antagonists is described. The compounds described are high affinity histamine H3 antagonists.
Michael Letavic +2 more
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Studies on histamine and histamine antagonists
Journal of Allergy, 1948Abstract 1.1. The results of some experiments on histamine and antihistaminic drugs in allergic patients were reported. 2.2. A histamine release from allergic skin reactions was shown. 3.3. A disturbed histamine metabolism was shown in allergic patients by an increase of blood histamine after histamine injection (histamine tolerance curve) and ...
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Histamine Agonists and Antagonists
Acta Oto-Laryngologica, 1991The role of histamine in brain function is discussed. A brief review is presented on the three types of histamine receptors with regard to their biochemistry and functions. The agonists and antagonists of these three classes of histamine receptors are discussed, together with the role such compounds play in clinical therapy and pharmacology.
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Histamine and Histamine Receptor Antagonists in Cancer Biology
Inflammation & Allergy - Drug Targets, 2010Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth. These various biological effects are mediated through the activation of specific histamine receptors (H1, H2, H3, and H4) that differ in their tissue expression patterns and functions.
Bruno, Blaya +8 more
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Histamine, histamine antagonists and regional blood flow
European Journal of Pharmacology, 1977The effects of mepyramine, a selective histamine H1-receptor antagonist, and metiamide, a selective histamine H2-receptor antagonist, have been determined on the cardiovascular response to intravenous infusions of a large dose of histamine, 1 X 10(-7) mol/kg/min.
B M, Johnston, D A, Owen
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Evidence that tamoxifen is a histamine antagonist
Biochemical and Biophysical Research Communications, 1985Recently we reported that both the triphenylethylene antiestrogen tamoxifen, and the novel compound N,N-diethyl-2-[(4 phenylmethyl)-phenoxy]-ethanamine. HCl (DPPE), which is selective for the antiestrogen binding site, may be histamine antagonists and have suggested that the antiestrogen binding site may be a growth-promoting histamine receptor ...
E A, Kroeger, L J, Brandes
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Histamine and Histamine Antagonists
1991Together with the two previous volumes of the "Handbook of Experimental Pharmacology" on histamine and antihistamines (volume 18, part 1, 1966 and part 2, 1978), the present volume yields a picture of a still rapidly developing field of research. It covers the process in histamine research during the past two decades. As a result of a consensus meeting
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Histamine and its antagonists in asthma
Journal of Allergy and Clinical Immunology, 1989Histamine has been recognized as a potent effector agent in allergic responses for many years. Windaus and Vogt’ first synthesized histamine in 1907, but it was Dale and Laidlaw who originally suggested that this substance could be liberated during an anaphylactic reaction when they observed that the features of anaphylaxis could be reproduced by the ...
P, Rafferty, S T, Holgate
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The evaluation of histamine antagonists in man
European Journal of Clinical Pharmacology, 1971A new method for evaluating histamine antagonists in man is described based on diminution of the effects of intradermal histamine. The inter and intra subject variability of such effects is examined experimentally and previous descriptions reviewed. Measures are adopted to minimise the effects and so achieve maximum economy of drug administrations and ...
A S, Fowle, D T, Hughes, G J, Knight
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