Results 61 to 70 of about 53,301 (333)

Real-world Evidence for Improved Outcomes with Histamine Antagonists and Aspirin in 22,560 COVID-19 Patients [PDF]

Signal Transduct Target Ther, 2021
Mura C, Preissner S, Nahles S, Heiland M, Bourne P, Preissner R.   +5 more
europepmc   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Heteroreceptor complexes formed by dopamine D1, histamine H3 and N-methyl-D-aspartate glutamate receptors as targets to prevent neuronal death in Alzheimer's disease [PDF]

, 2017
Alzheimer’s disease (AD) is a neurodegenerative disorder causing progressive memory loss and cognitive dysfunction. Anti-AD strategies targeting cell receptors consider them as isolated units. However, many cell surface receptors cooperate and physically
A Thathiah, AD Medhurst, AI Hersi, Antonio Cortés, C Ferrada, C Fiorentini, C Pillot, Carme Lluís, CG Mcnamara, D Wang, D Wilkinson, David Moreno-Delgado, DO Borroto-Escuela, DR Borchelt, DR Borchelt, E Moreno, E Moreno, Enric I. Canela, Estefanía Moreno, FJS Lee, G Navarro, G Navarro, G Navarro, G Navarro, Gemma Navarro, H Kaphzan, HJ Seong, IM Mazurkiewicz-Kwilecki, J Chen, J Wu, JD Brioni, Josefa Mallol, JY Koh, L Fernández-Novoa, M Wang, Mar Rodríguez-Ruiz, MB Passani, NP Sidharthan, P Giménez-Xavier, P Panula, Peter J. McCormick, PL Chazot, R Cacabelos, RA Grove, Rafael Franco, RF Cowburn, RJ Rodrigues, S Jürgensen, S-M Jeon, Vicent Casadó, WD Le   +50 more
core   +1 more source

Layered double hydroxides‐based nanozymes for effective biomedical applications: A review and future perspectives

BMEMat, EarlyView.
In this review, we introduced the preparation methods of LDHzymes and discussed their catalytic activity and mechanisms. Subsequently, the applications of LDHzymes in biomedical were discussed. Finally, potential future work on LDHzymes was proposed to better design these new types of nanozymes.
Jiawei Cui, Lu Zhang, Junyi Li, Yue Chen, Sheng Dai, Manfred F. Maitz, Ansha Zhao, Ping Yang   +7 more
wiley   +1 more source

Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including ...
Gustavo Provensi, Alessio Nocentini, Maria Beatrice Passani, Patrizio Blandina, Claudiu T. Supuran   +4 more
doaj   +1 more source

Pepducins as a potential treatment strategy for asthma and COPD. [PDF]

, 2018
Current therapies to treat asthma and other airway diseases primarily include anti-inflammatory agents and bronchodilators. Anti-inflammatory agents target trafficking and resident immunocytes and structural cells, while bronchodilators act to prevent or
Benovic, Jeffrey L., Liggett, Stephen B B., Panettieri, Reynold A., Penn, Raymond B., Pera, Tonio   +4 more
core   +2 more sources

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

BMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang, Lu Han, He‐Qing Cai, Xin‐Yu Xue, Yi‐Fei Song, Wu‐Lin Xin, Ying‐Ze Wang, Peng Liu, Juan Liu   +8 more
wiley   +1 more source

Comparative Study to Assess Clinical Efficacy of Leukotriene Receptor Antagonist and Antihistamines in the Treatment of Allergic Rhinitis

Bengal Journal of Otolaryngology and Head Neck Surgery, 2017
Introduction Pharmacologic treatment  options for allergic rhinitis include intranasal corticosteroids, oral and topical antihistamines, decongestants, intranasal cromolyn, intranasal anticholinergics and leukotriene receptor antagonists.
Gurpreet Kaur, Rachna Dhingra, Manjinder Singh   +2 more
doaj   +3 more sources

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Frontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada   +7 more
doaj   +1 more source

Sites of action of sleep and wake drugs: insights from model organisms [PDF]

, 2013
Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core   +1 more source