Results 171 to 180 of about 7,687 (206)
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Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties
European Journal of Pharmacology, 2005Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse nucleus accumbens slices showed that DPP (10 microM)
Gennady B, Lapa +4 more
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Revue medicale de Bruxelles, 2003
Histamine is an important mediator for early phase allergic reactions that are involved in atopic diseases, mediated by specific IgE antibodies. After allergenic contact, its liberation induces unpleasant symptoms like itching, several manifestations as local vasodilatation, bronchoconstriction, mucus hypersecretion.
J, Duchateau, M, Heenen, J, Sternon
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Histamine is an important mediator for early phase allergic reactions that are involved in atopic diseases, mediated by specific IgE antibodies. After allergenic contact, its liberation induces unpleasant symptoms like itching, several manifestations as local vasodilatation, bronchoconstriction, mucus hypersecretion.
J, Duchateau, M, Heenen, J, Sternon
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Clinical comparison of histamine H1–receptor antagonist drugs
Journal of Allergy and Clinical Immunology, 1996Nearly 40 million Americans have symptoms of upper respiratory allergies, making antihistamines among the most frequently used pharmacologic agents. Although there are mediators of allergic symptoms in addition to histamine, therapy for allergic rhinitis and urticaria has focused upon the use of antihistamines.
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The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats
Neuroscience Letters, 1997The effect of the histamine H1-receptor antagonist chlorpheniramine on inhibitory avoidance conditioning was investigated in 31-month-old rats, using a one-trial step-through avoidance task. Immediately after the learning trial, old rats were injected intraperitoneally with 5 or 10 mg/kg d-chlorpheniramine.
C, Frisch, R U, Hasenöhrl, J P, Huston
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The H1-histamine antagonist Dithiaden® inhibits human platelets in vitro
Inflammation Research, 1996Cationic amphiphilic drugs (CAD), including antihistaminics, inhibit platelet aggregation in vitro [1]. We demonstrated recently that Dithiaden® (DIT) antagonised stimulated rat platelets at the level of the arachidonic acid pathway suggesting that phospholipase A2 may be the si te of DIT action [2].
R, Nosál, V, Jancinová, E, Danihelová
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Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist
European Journal of Pharmacology: Molecular Pharmacology, 1991In human astrocytoma cells (1321N1), trifluoperazine potently inhibited histamine-induced phosphoinositide hydrolysis, while it slightly inhibited carbachol-induced phosphoinositide hydrolysis. Trifluoperazine as well as diphenhydramine inhibited [3H]mepyramine binding in astrocytoma cell membranes with Ki values of 0.052 microM and 0.005 microM ...
N, Nakahata +4 more
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Nonsedating histamine H1-receptor antagonists.
Clinical pharmacy, 1989The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosages of the nonsedating histamine H1-receptor antagonists terfenadine, astemizole, loratadine, and acrivastine are reviewed. Terfenadine and astemizole are chemically unrelated to histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine ...
K V, Mann, J P, Crowe, K J, Tietze
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Determination of some histamine H1-receptor antagonists in dosage forms
Journal of Pharmaceutical and Biomedical Analysis, 2002Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with chloroform and subsequently measured ...
Azza A, Gazy +4 more
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CNS effects of histamine H1 antagonists
Clinical & Experimental Allergy, 1999An accurate evaluation of the functions of the human brain during the administration of drugs is one of the most complex tasks in medical science. In the case of H1 antihistamines, there are many biases that can explain why the interpretation of pharmacological data and those from clinical studies can be very difficult.
J P, Rihoux, F, Donnelly
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Clinical Pharmacology of New Histamiine H1 Receptor Antagonists
Clinical Pharmacokinetics, 1999The recently introduced H1 receptor antagonists ebastine, fexofenadine and mizolastine, and the relatively new H1 antagonists acrivastine, astemizole, azelastine, cetirizine, levocabastine and loratadine, are diverse in terms of chemical structure and clinical pharmacology, although they have similar efficacy in the treatment of patients with allergic ...
F E, Simons, K J, Simons
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