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A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor
European Journal of Pharmacology, 2007Eosinophilic chemokines and histamine play distinct but important roles in allergic diseases. Inhibition of both eosinophilic chemokines and histamine, therefore, is an ideal strategy for the treatment of allergic inflammation, such as asthma, allergic rhinitis, and atopic dermatitis.
Keiko, Suzuki +7 more
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The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats
Neuroscience Letters, 1997The effect of the histamine H1-receptor antagonist chlorpheniramine on inhibitory avoidance conditioning was investigated in 31-month-old rats, using a one-trial step-through avoidance task. Immediately after the learning trial, old rats were injected intraperitoneally with 5 or 10 mg/kg d-chlorpheniramine.
C, Frisch, R U, Hasenöhrl, J P, Huston
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Agents and Actions, 1973
Histamine methyltransferase from pig antrum mucosa was inhibited by 33 H1-receptor antagonists, by the H2-receptor antagonists burimamide and metiamide and by the burimamide analogue 5-methylburimamide, which did neither act on H1-nor on H2-receptors.
H, Barth, I, Niemeyer, W, Lorenz
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Histamine methyltransferase from pig antrum mucosa was inhibited by 33 H1-receptor antagonists, by the H2-receptor antagonists burimamide and metiamide and by the burimamide analogue 5-methylburimamide, which did neither act on H1-nor on H2-receptors.
H, Barth, I, Niemeyer, W, Lorenz
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The H1-histamine antagonist Dithiaden® inhibits human platelets in vitro
Inflammation Research, 1996Cationic amphiphilic drugs (CAD), including antihistaminics, inhibit platelet aggregation in vitro [1]. We demonstrated recently that Dithiaden® (DIT) antagonised stimulated rat platelets at the level of the arachidonic acid pathway suggesting that phospholipase A2 may be the si te of DIT action [2].
R, Nosál, V, Jancinová, E, Danihelová
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Antagonists of H1 Receptors of Histamine: Recent Developments
1991In the previous handbook of this series on this topic (Casy 1978), attention was drawn to the fact that most compounds known at that time which effectively antagonized histamine at H1-receptor sites could be described by the general structure (1) Open image in new window (1)
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Histamine and histamine H1- and H2-receptor antagonists in acute inflammation
Biochemical Society Transactions, 1980D A, Owen, D F, Woodward
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Histamine(H1) antagonists and airway hyperreactivity in the guinea-pig.
Agents and actions. Supplements, 1992Ketotifen inhibits development of airway hyperreactivity in guinea-pigs exposed to PAF, (+/-)isoprenaline, immune complexes or endotoxin. Ketotifen is not a competitive histamine(H1) antagonist, so that it cannot be concluded that there is mandatory involvement of histamine in the development or expression of these forms of airway hyperreactivity. This
K, Hoshiko, I D, Chapman, J, Morley
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