Results 171 to 180 of about 251,504 (224)

Inhibition by Cations of Antagonist Binding to Histamine H1-Receptors

1991
The binding of the quaternary radioligand [3H] QMDP to the histamine H1-receptor was inhibited by a series of mono- and di-valent cations. The order of potency was Hg2+ greater than Cd2+ greater than Zn2+ greater than Ni2+ greater than Co2+ greater than Mn2+ greater than Ca2+ greater than Mg2+ greater than Li+ = Na+ greater than K+ greater than Cs ...
J M, Treherne, J S, Stern, W J, Flack, J M, Young   +3 more
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Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor

Molecular Pharmacology, 2009
The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R antagonists as antiallergy drugs and to address the question of whether H(1)R ligands bind to hH(4)R.
Karl-Friedrich, Deml, Silke, Beermann, Detlef, Neumann, Andrea, Strasser, Roland, Seifert   +4 more
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Histamine H1-receptor antagonist activity assessed in conscious dogs

Journal of Pharmacological Methods, 1987
A simple, minimally invasive technique is described which allows assessment of histamine H1-receptor antagonist activity in conscious dogs. The technique is based on the inhibition of the tachycardia caused by intravenous administration of the H1-receptor agonist, 2-pyridylethylamine.
A, Wright, P, Raval, R J, Eden, D A, Owen   +3 more
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Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties

European Journal of Pharmacology, 2005
Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse nucleus accumbens slices showed that DPP (10 microM)
Gennady B, Lapa, Tiffany A, Mathews, Jill, Harp, Evgeny A, Budygin, Sara R, Jones   +4 more
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Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist

European Journal of Pharmacology: Molecular Pharmacology, 1991
In human astrocytoma cells (1321N1), trifluoperazine potently inhibited histamine-induced phosphoinositide hydrolysis, while it slightly inhibited carbachol-induced phosphoinositide hydrolysis. Trifluoperazine as well as diphenhydramine inhibited [3H]mepyramine binding in astrocytoma cell membranes with Ki values of 0.052 microM and 0.005 microM ...
N, Nakahata, H, Ishimoto, A, Takahashi, K, Ohmori, M, Kurita   +4 more
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Clinical comparison of histamine H1–receptor antagonist drugs

Journal of Allergy and Clinical Immunology, 1996
Nearly 40 million Americans have symptoms of upper respiratory allergies, making antihistamines among the most frequently used pharmacologic agents. Although there are mediators of allergic symptoms in addition to histamine, therapy for allergic rhinitis and urticaria has focused upon the use of antihistamines.
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Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis

Pain, 1997
Itching is a well known side-effect of opiate therapy. To gain insight into the possible contribution of opiate receptors to itching we compared the antipruritic effect of naltrexone (Nemexin), an opiate antagonist, to an H1-receptor antagonist and to placebo.
G, Heyer, M, Dotzer, L T, Diepgen, O H, Handwerker   +3 more
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Nonsedating histamine H1-receptor antagonists.

Clinical pharmacy, 1989
The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosages of the nonsedating histamine H1-receptor antagonists terfenadine, astemizole, loratadine, and acrivastine are reviewed. Terfenadine and astemizole are chemically unrelated to histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine ...
K V, Mann, J P, Crowe, K J, Tietze
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Determination of some histamine H1-receptor antagonists in dosage forms

Journal of Pharmaceutical and Biomedical Analysis, 2002
Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with chloroform and subsequently measured ...
Azza A, Gazy, Hoda, Mahgoub, F A, El-Yazbi, M A, El-Sayed, Rasha M, Youssef   +4 more
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Chemistry of Anti-H1 Histamine Antagonists

1978
In this Chapter a survey and discussion of the chemistry of compounds which antagonize the effects of histamine at H1 receptors are presented. Ellis (1969) has compiled an extensive list of reviews on histamine, 5-hydroxytryptamine, and their antagonists, several of which include some account of the chemical aspects of antihistaminics.
openaire   +1 more source