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Haematological Adverse Effects of Histamine H2-Receptor Antagonists
Medical Toxicology, 1988Histamine H2-receptor antagonists are widely used in the treatment of gastrointestinal diseases related to gastric acid hypersecretion. Cimetidine was introduced into medical practice in 1976 and ranitidine, famotidine and nizatidine in 1981, 1985 and 1987, respectively. Haematological adverse effects are relatively uncommon and most have been reported
J P, Aymard +5 more
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A radioimmunoassay for the histamine H2-antagonist, tiotidine
Agents and Actions, 1984A specific and sensitive radioimmunoassay (RIA) for the histamine H2-antagonist, tiotidine, has been developed. The assay is based upon competition of tiotidine with [3H]-tiotidine for antibody (Ab) obtained from immunized rabbits. The immunogen used was a glutaraldehyde coupled conjugate of the tiotidine derivative (ICI 147,655) and bovine serum ...
P, Dobson, T O, Yellin
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Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists
Drug Safety, 2001The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions. Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction.
A A, Fisher, D G, Le Couteur
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Histamine H2-receptor antagonists inhibit enzymic histamine degradation in human skin
Clinical and Experimental Dermatology, 1979Summary The histamine H2-receptor antagonists burimamide and cimetidine cause inhibition of human skin histamine-N-methyl transferase (HMT) in the dose range 10-3–10-4 M. Amodiaquin, a recognized inhibitor of animal HMT, also produced dose-related inhibition of human HMT.
R, Corbett, M W, Greaves
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The new histamine H2-receptor antagonist ranitidine
Research in Experimental Medicine, 1981The antisecretory effects of a new histamine H2-receptor antagonist, ranitidine hydrochloride, have been investigated on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration of 150 mg. In addition, the 24-h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition ...
H G, Dammann +3 more
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