Results 51 to 60 of about 356,503 (221)

Risk Stratification for Rebleeding in Obscure Gastrointestinal Bleeding After Comprehensive Gastrointestinal Evaluation

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Background and Aim: Obscure gastrointestinal bleeding (OGIB) is defined as bleeding of unknown origin after comprehensive upper, lower, and small‐bowel evaluations. However, the incidence and predictors of rebleeding after negative comprehensive gastrointestinal evaluation remain unclear.
Sachiyo Onishi, Kiichi Otani, Naoya Masuda, Hiroki Taniguchi, Kentaro Kojima, Jun Takada, Masaya Kubota, Takashi Ibuka, Masahito Shimizu   +8 more
wiley   +1 more source

Histamine H1 and H2 Receptor Antagonists Accelerate Skin Barrier Repair and Prevent Epidermal Hyperplasia Induced by Barrier Disruption in a Dry Environment [PDF]

, 2001
Keratinocytes have histamine H1 and H2 receptors, but their functions are poorly understood. To clarify the role of histamine receptors in the epidermis, we examined the effects of histamine receptor antagonists and agonists applied epicutaneously on the
Denda, Mitsuhiro, Hirao, Tetsuji, Ashida, Yutaka   +2 more
core   +1 more source

Histamine receptors in GtoPdb v.2021.3 [PDF]

, 2021
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 173]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Levi, Roberto, Leurs, Rob, Cowart, Marlon, Hill, Stephen J., Young, J. Michael, Gutzmer, Ralf, Seifert, Roland, Ganellin, C. Robin, Shankley, Nigel P., Timmerman, Henk, Haas, Helmut L., Stark, Holger, Panula, Pertti, Schunack, Walter, Chazot, Paul, Fukui, Hiroyuki, Liu, Steve, Schwartz, Jean-Charles, Hills, Rebecca, Thurmond, Robin   +19 more
core   +1 more source

Decoding functional specialization in G protein‐coupled receptors (GPCRs) through evolution‐guided residue profiling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6007-6027, October 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are integral membrane proteins that mediate physiological processes by enabling cells to detect and respond to diverse stimuli. Although many subfamily‐specific functional hotspots have been described, the family‐wide determinants of common and subfamily‐specific functions remain incomplete ...
Berkay Selçuk, Gunnar Schulte, Igor B. Zhulin, Ogün Adebali   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia. [PDF]

, 2011
The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of ...
LETHBRIDGE, NATASHA,LOUSIE
core  

Histamine receptors in GtoPdb v.2023.1 [PDF]

, 2023
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Hill, Stephen J., Young, J. Michael, Steve Liu, Jean-Charles Schwartz, Shankley, Nigel P., Haas, Helmut L., Holger Stark, Nigel P. Shankley, Robin Thurmond, Paul Chazot, Stephen J. Hill, Fukui, Hiroyuki, Hills, Rebecca, J. Michael Young, Levi, Roberto, Leurs, Rob, Marlon Cowart, Rebecca Hills, Cowart, Marlon, Gutzmer, Ralf, C. Robin Ganellin, Seifert, Roland, Ganellin, C. Robin, Rob Leurs, Roberto Levi, Timmerman, Henk, Stark, Holger, Panula, Pertti, Hiroyuki Fukui, Schunack, Walter, Chazot, Paul, Roland Seifert, Liu, Steve, Schwartz, Jean-Charles, Walter Schunack, Henk Timmerman, Pertti Panula, Helmut L. Haas, Thurmond, Robin, Ralf Gutzmer   +39 more
core   +1 more source

Stimulation of Histamine H1 Receptor Up-Regulates Histamine H1 Receptor Itself Through Activation of Receptor Gene Transcription

Journal of Pharmacological Sciences, 2007
Histamine is a major mediator in allergy acting mainly through the histamine H1 receptor (H1R). Although H1R up-regulation has been suggested as an important step for induction of allergic symptoms, little is known about the regulation of H1R level. Here
Asish K. Das, Sachiho Yoshimura, Ryoko Mishima, Katsumi Fujimoto, Hiroyuki Mizuguchi, Shrabanti Dev, Yousuke Wakayama, Yoshiaki Kitamura, Shuhei Horio, Noriaki Takeda, Hiroyuki Fukui   +10 more
doaj   +1 more source

Validation of the European Society of Cardiology Ischemic and Bleeding Risk Criteria for Risk Stratification After Endovascular Therapy in Japanese Patients With Lower Extremity Artery Disease

Catheterization and Cardiovascular Interventions, Volume 108, Issue 3, Page 801-815, September 1, 2026.
ABSTRACT Background The European Society of Cardiology (ESC) guidelines for peripheral artery disease recommend antithrombotic strategies based on high ischemic risk (HIR) and high bleeding risk (HBR) criteria. However, their prognostic value in patients with lower extremity artery disease (LEAD) undergoing endovascular therapy (EVT) remains unclear ...
Hirokazu Shimono, Daisuke Kanda, Akihiro Tokushige, Nobuhiro Ito, Yutaro Nomoto, Hiroyuki Tabata, Kenta Ohmure, Takuro Kubozono, Mitsuru Ohishi   +8 more
wiley   +1 more source

Acid suppressants use and the risk of dementia: A population-based propensity score-matched cohort study.

PLoS ONE, 2020
In this population-based propensity score matched (PSM) cohort study, we aimed to investigate the risk of developing dementia with the use of acid suppressants, including proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2 antagonists).
Chia-Liang Wu, Wei-Yi Lei, Jaw-Shing Wang, Ching-En Lin, Chien-Lin Chen, Shu-Hui Wen   +5 more
doaj   +1 more source