Results 51 to 60 of about 9,091 (225)

Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia. [PDF]

, 2011
The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of ...
LETHBRIDGE, NATASHA,LOUSIE
core  

Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,

, 2003
Fluorescently labeled histamine H2 receptor antagonists were synthesized starting from N-cyano-N′-[3-(3-piperidin-1-ylmethylphenoxy)propyl]guanidines with an additional N″-ω-aminoalkyl substituent (chain lengths 2–8 methylene groups) or from 3-(3 ...
Bernhardt, G, Elz, S, Li, LT, Buschauer, Armin, Peng, SQ, Li, Liantao, Kracht, Julia, Peng, Shiqi, Kracht, J, Bernhardt, Günther, Elz, Sigurd, Buschauer, A   +11 more
core   +1 more source

Acid suppressants use and the risk of dementia: A population-based propensity score-matched cohort study.

PLoS ONE, 2020
In this population-based propensity score matched (PSM) cohort study, we aimed to investigate the risk of developing dementia with the use of acid suppressants, including proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2 antagonists).
Chia-Liang Wu, Wei-Yi Lei, Jaw-Shing Wang, Ching-En Lin, Chien-Lin Chen, Shu-Hui Wen   +5 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Effect of Histamine H2-Receptor Antagonists on Acute Inflammatory of the Rat Paw Oedema

, 1989
The effect of three histamine H2-antagonists, cimetidine, ranitidine, and loxtidine, on acute rat paw oedema induced by histamine, carrageenan or complete Freund’s adjuvant, have been examined.
Cyprain C Umezurike, Charles I Ezeamuzie
core   +1 more source

The relation between antihistamine medication during early pregnancy & birth defects

Egyptian Journal of Medical Human Genetics, 2015
Antihistamines are a group of medications which can inhibit various histaminic actions at one of two histamine receptors (H1 or H2). H1 receptor antagonists are used for the relief of allergic dermatological and nondermatological conditions.
Rabah M. Shawky, Neveen S. Seifeldin
doaj   +1 more source

A Robust and Universal LC–MS/MS Method for Determination of N‐Nitrosodimethylamine in Pharmaceuticals Using a C30 Column

Journal of Separation Science, Volume 49, Issue 6, June 2026.
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An, Unyong Kim, Sumin Seo, Jiyu Kim, Chohee Jeong, Woojin Jeong, Eunjin Ko, Juhyeon Kim, Hyun‐Deok Cho, Sang Beom Han   +9 more
wiley   +1 more source

Histamine analogues, XXXV: 2-substituted histamine derivatives containing classical moieties of H2-antagonists--a novel class of H1-agonists

, 1993
A new type of H1-agonists resulted from the combination of the essential histamine structure with parts of H2-antagonists. 2,4-Disubstituted imidazole derivatives were synthesized by reaction of imidic acid methyl esters with 1,3-dihydroxypropanone, 1,4 ...
Volkmar Zingel, Sigurd Elz, Walter Schunack, Zingel, V., Elz, Sigurd, Schunack, W.   +5 more
core   +1 more source

Mast Cells May Differentially Regulate Growth of Lymphoid Neoplasms by Opposite Modulation of Histamine Receptors

Frontiers in Oncology, 2019
Cancer microenvironment is complex and consists of various immune cells. There is evidence for mast cell (MC) infiltration of tumors, but their role thereof is poorly understood.
Sandeep Paudel, Deeksha Mehtani, Niti Puri   +2 more
doaj   +1 more source

Genome Mining Approaches for Toxicant Discovery: A Case Study Examining Receptor Proteins for Pest Management in New Zealand

New Zealand Journal of Zoology, Volume 53, Issue 2, June 2026.
Pest control is a global challenge for agriculture and biodiversity conservation, with the use of existing vertebrate pesticides increasingly constrained by regulatory, environmental, and social pressures. There is an urgent need for safer and more species‐selective toxicants, but the development of novel vertebrate pesticides remains technically ...
Erica R. Hendrikse, Natalie J. Forsdick, Wanting Jiao, Brian Hopkins   +3 more
wiley   +1 more source