RELEASE OF HISTAMINE BY H2-RECEPTOR ANTAGONISTS [PDF]
The Lancet, 1982 letter
Parkin, J. V. +4 more
core +8 more sources
Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1 [PDF]
MicrobiologyOpen, 2019 The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling.
Robert Fultz +9 more
doaj +2 more sources
The Impact of H1–H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis [PDF]
PharmaceuticalsBackground/Objectives: The global prevalence and incidence of inflammatory bowel diseases have risen in the past two decades. Among them, Crohn’s disease and ulcerative colitis are still challenging to treat due to vascular and proliferative alterations.
Bartosz Bogielski +16 more
doaj +2 more sources
Histamine H2-receptor antagonists for urticaria. [PDF]
Cochrane Database Syst Rev, 2012 Urticaria is a common skin disease characterised by itching weals or hives, which can occur almost anywhere on the body. There are a number of different subtypes and a range of available treatment options. There is lack of agreement on the efficacy of H2-receptor antagonists used in the treatment of urticaria.To assess the safety and effectiveness of ...
Fedorowicz Z, van Zuuren EJ, Hu N.
europepmc +5 more sources
Physiological implications of biased signaling at histamine H2 receptors. [PDF]
Frontiers in Pharmacology, 2015 Histamine mediates numerous functions acting through its four receptor subtypes all belonging to the large family of seven transmembrane G-protein coupled receptors (GPCRs).
Natalia eAlonso +14 more
doaj +3 more sources
The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions
Frontiers in Pharmacology, 2021 This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann +4 more
doaj +1 more source
Insight into the Mode of Action of 8-Hydroxyquinoline-Based Blockers on the Histamine Receptor 2
Biosensors, 2023 Histamine receptor 2 (HRH2) blockers are used to treat peptic ulcers and gastric reflux. Chlorquinaldol and chloroxine, which contain an 8-hydroxyquinoline (8HQ) core, have recently been identified as blocking HRH2.
Amisha Patel +4 more
doaj +1 more source
Histamine can be Formed and Degraded in the Human and Mouse Heart
Frontiers in Pharmacology, 2021 Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic effects (PCE) in humans ...
Joachim Neumann +12 more
doaj +1 more source
The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands. [PDF]
PLoS ONE, 2016 In this article we report a combined experimental and computational study concerning the effects of deuteration on the binding of histamine and two other histaminergic agonists to 3H-tiotidine-labeled histamine H2 receptor in neonatal rat astrocytes ...
Mojca Kržan +7 more
doaj +1 more source
Journal of Pharmacological Sciences, 2023 Histamine is a well-known inflammatory mediator, but how histamine induces angiogenesis remains poorly understood. In the present study, we demonstrated a dose-dependent dynamic tube formation in the human endothelial cell line EA.hy926 in the presence ...
Omer Faruk Hatipoglu +8 more
doaj +1 more source