Results 171 to 180 of about 1,480,236 (218)

Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists

Drug Safety, 2001
The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions. Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction.
A A, Fisher, D G, Le Couteur
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Conformational analyses on histamine H2-receptor antagonists

Journal of Computer-Aided Molecular Design, 1990
In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations. The drugs studied were cimetidine, ranitidine, famotidine, roxatidine and the conformationally more restricted ICI127032.
Hans-Dieter Höltje, Anita Batzenschlager   +1 more
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Prolactin responses to histamine H2 receptor antagonists

Acta Endocrinologica, 1980
Abstract. We have compared the effects of cimetidine and SK&F 92994, a new more potent histamine H2 receptor antagonist, on serum prolactin, and also assessed the effect of the H2 receptor agonist impromidine on the response to cimetidine. As previously reported, cimetidine 200 mg given as an iv bolus dose produced a marked rise in serum prolactin,
P C, Sharpe, M A, Melvin, J G, Mills, W L, Burland, G V, Groom   +4 more
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Stimulation of cerebral histamine H2 receptors by clonidine

Nature, 1976
CLONIDINE (2-[(2,6-dichlorophenyl)amino]-2-imidazoline) is a potent antihypertensive agent whose site of action is believed to be in the central nervous system1 but its mechanism of action is far from clear. Because of its effects on peripheral tissue, it has been generally accepted that the drug stimulates alpha-adrenergic receptors1.
Y, Audigier, A, Virion, J, Schwartz
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Histamine H2-receptor antagonists.

Advances in internal medicine, 1978
Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to all known secretagogues and, in contrast to anticholinergic drugs ...
M, Feldman, C T, Richardson
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Histamine H2 receptor: Involvement in gastric ulceration

Life Sciences, 1976
The involvement of the H1 and H2 receptors for histamine in the pathogenesis of gastric ulcers was investigated in rats. Metiamide, an H2 receptor antagonist, reliably reduced ulceration produced by stress alone or by a combination of stress and aspirin.
P A, Brown, T H, Brown, J, Vernikos-Danellis   +2 more
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Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa

The Histochemical Journal, 1977
Histamine stimulates acid secretion by the parietal cell and this secretion is inhibited by the histamine H2-receptor antagonists. Whole body autoradiography showed that radioactivity from 14C-histamine was localized in the artery walls of the stomach and in the muscularis mucosae, but that the level in the fundic mucosa was the same as the blood. When
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[The H1 and H2 histamine receptors].

Allergie et immunologie, 1989
Histamine is a major mediator of the allergic reactions. Histamine have different actions: contraction of smooth muscles, vascular action, increase in gastric and adrenal medulla secretion. Effects on central or peripheral nervous system are discussed. The specific H1 or H2 activity explains the different configurations of histamine. The specificity of
F, Ruff, M C, Santais
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Structural elements of H1- and H2-receptors of histamine

General Pharmacology: The Vascular System, 1980
Abstract This article sets out the proposed schemes of histamine H 1 - and H 2 -receptors. These schemes are based on the analysis of histamine agonists activity.
L L, Grechishkin, V L, Goldfarb, L K, Gavrovskaya, N B, Brovtsyna   +3 more
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Histamine H2 Receptor Biased Signaling Methods

2017
Fil: Fernandez, Natalia Cristina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Farmacologicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica.
Fernandez, Natalia Cristina, Shayo, Carina Claudia, Davio, Carlos Alberto, Monczor, Federico   +3 more
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