Results 221 to 230 of about 28,670 (268)

Histamine H2 receptors in rat renal glomeruli

Biochemical Pharmacology, 1982
The aim of this study was to demonstrate histamine-H2 receptors in glomeruli isolated from rat renal cortex and to correlate binding to stimulation by histamine of glomerular cyclic AMP concentration. Binding studies were performed at 10-12 degrees C using [3H]cimetidine as a tracer.
D, Chansel, J P, Oudinet, M P, Nivez, R, Ardaillou   +3 more
openaire   +2 more sources

Conformational analyses on histamine H2-receptor antagonists

Journal of Computer-Aided Molecular Design, 1990
In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations. The drugs studied were cimetidine, ranitidine, famotidine, roxatidine and the conformationally more restricted ICI127032.
H D, Höltje, A, Batzenschlager
openaire   +2 more sources

Potential histamine H2-receptor antagonists. 4. Benzylhistamines

Journal of Medicinal Chemistry, 1982
As part of our studies aimed at designing histamine H2-receptor antagonists, the effect on histaminergic activity of introducing benzyl substituents at various positions in the histamine molecule is described. New synthetic methods are reported for the novel 4-benzyl-, beta-benzyl- and 4,N tau-dibenylhistamines and the reported 2-benzylhistamine.
J C, Emmett, G J, Durant, C R, Ganellin, A M, Roe, J L, Turner   +4 more
openaire   +2 more sources

Histamine H2-Receptors and Gastric Secretion

1978
In 1966 Ash and Schild1 pointed out for the first time the existence of different types of histamine receptors. They defined as H1 receptors those which could be blocked by the classical antihistaminics and non-H1 receptors those which could not be blocked.
openaire   +2 more sources

Inhibition of Histamine Release by Histamine controlled by H2 Receptor

Nature, 1973
AGENTS which increase the intracellular level of adenosine 3′-5′-monophosphate (cyclic AMP) in human leukocyte preparations such as the catecholamines, methylxanthines and prostaglandins, inhibit the antigen induced, IgE antibody mediated release of histamine from human leukocytes (basophils)1–3.
L M, Lichtenstein, E, Gillespie
openaire   +2 more sources

Multiple Signaling Pathways of Histamine H2 Receptors

1991
Histamine H2 receptor (H2R) has been shown to be coupled to adenylate cyclase. However, we have previously demonstrated that H2R-specific stimulation also activated phospholipase C in human HL-60 promyelocytic leukemia cells (Mitsuhashi M. et al. J. Biol. Chem. 264:18356, 1989).
M, Mitsuhashi, D G, Payan
openaire   +2 more sources

Metiamide—An orally active histamine H2-receptor antagonist

Agents and Actions, 1973
Metiamide has been found to be about 10 times more active than burimamide in vitro in antagonizing histamine H2-receptors and nearly 5 times more active in vivo as an antagonist of histamine or pentagastrin-stimulated secretion. Effective oral ED50 doses for inhibition have been estimated as 25 μmole kg−1 against basal secretion in rats and 16 μmole kg−
J W, Black, W A, Duncan, J C, Emmett, C R, Ganellin, T, Hesselbo, M E, Parsons, J H, Wyllie   +6 more
openaire   +2 more sources

H1and H2 histamine receptors on Aplysia neurones

Nature, 1975
WE have found two types of histamine receptor on neurones of the mollusc Aplysia corresponding to those already known in mammals. The presence of these specific receptors is consistent with the suggestion that histamine acts as a neurotransmitter.
D O, Carpenter, G L, Gaubatz
openaire   +2 more sources

Histamin H2-receptor blockers

2015
This review is about clinical pharmacology of histamine H2-receptor antagonists and their prophylactic and therapeutic effects in peptic ulser disease, Zollinger-Ellison Syndrome, gastroesophageal reflux and acute stress ulcers and erosions which are known asid-peptic disorders. H2-receptor blocker drugs (Cimetidine, Ranitidine, Famotidine, Nizatidine)
ACET, Dr. Ahmet, ÖLMEZ, Dr. Ercüment
openaire   +1 more source

Histamin-H2-Receptor-Antagonismus

1978
Receptoren sind als hypothetische Orte an der Zelloberflache aufzufassen, deren Verbindung mit einem Agonisten (physiologischer Wirkstoff oder Pharmakon) von einer spezifischen Leistung der Zelle gefolgt ist. Antagonisten besitzen ebenfalls eine Affinitat zum Receptor, konnen aber die spezifische Wirkung in der Zelle nicht hervorrufen. Sie konkurrieren
openaire   +1 more source