Results 61 to 70 of about 13,967 (254)
Narcolepsy and rapid eye movement sleep
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini +4 more
wiley +1 more source
A receptor-based analysis of local ecosystems in the human brain. [PDF]
, 2017 BackgroundAs a complex system, the brain is a self-organizing entity that depends on local interactions among cells. Its regions (anatomically defined nuclei and areas) can be conceptualized as cellular ecosystems, but the similarity of their functional ...
Janušonis, Skirmantas
core +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2019 Purpose: Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine, non-sedating, rapid and very long acting used in symptoms associated with allergic ...
Natalia Kordulewska +4 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Background: There is currently no effective treatment for cognitive impairment associated with schizophrenia (CIAS). Recent studies have shown that increased histamine levels in the brain may help to improve CIAS symptoms.
Yongqian Wang +11 more
doaj +1 more source
Identification of histamine H3 receptor antagonists
The FASEB Journal, 2007 Histamine H 3 receptors (H 3 R) regulate the release of histamine and other neurotransmitters in the brain. H 3 R have been shown to modulate many functions, including feeding, sleep, and cognition, making them ...
Andria Lee Del Tredici +14 more
openaire +1 more source
Restless Legs Syndrome Associated With Fexofenadine Use: A Case Report
Clinical Case Reports, Volume 14, Issue 2, February 2026.Flowchart of possible fexofenadine‐induced RLS pathophysiology. ABSTRACT Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by an irresistible urge to move the legs, typically worsening at night and leading to sleep disturbance.
Abdulrahman M. Albeshry
wiley +1 more source
Tourette syndrome research highlights from 2016 [version 1; referees: 3 approved, 1 approved with reservations] [PDF]
, 2017 This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders.
Black, Kevin J
core +3 more sources
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
EJNMMI Research, 2018 Background The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions such as working ...
Takehito Ito +10 more
doaj +1 more source
Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells
Scientific Reports, 2021 Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is ...
Nobuki Matsumoto +5 more
doaj +1 more source