Results 61 to 70 of about 12,080 (218)

Tourette syndrome research highlights from 2016 [version 1; referees: 3 approved, 1 approved with reservations] [PDF]

, 2017
This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders.
Black, Kevin J
core   +3 more sources

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Frontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada   +7 more
doaj   +1 more source

Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor

Frontiers in Immunology, 2022
BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.
Shangze Gao, Shangze Gao, Shangze Gao, Keyue Liu, Wenhan Ku, Dengli Wang, Hidenori Wake, Handong Qiao, Kiyoshi Teshigawara, Masahiro Nishibori   +9 more
doaj   +1 more source

Heteroreceptor complexes formed by dopamine D1, histamine H3 and N-methyl-D-aspartate glutamate receptors as targets to prevent neuronal death in Alzheimer's disease [PDF]

, 2017
Alzheimer’s disease (AD) is a neurodegenerative disorder causing progressive memory loss and cognitive dysfunction. Anti-AD strategies targeting cell receptors consider them as isolated units. However, many cell surface receptors cooperate and physically
A Thathiah, AD Medhurst, AI Hersi, Antonio Cortés, C Ferrada, C Fiorentini, C Pillot, Carme Lluís, CG Mcnamara, D Wang, D Wilkinson, David Moreno-Delgado, DO Borroto-Escuela, DR Borchelt, DR Borchelt, E Moreno, E Moreno, Enric I. Canela, Estefanía Moreno, FJS Lee, G Navarro, G Navarro, G Navarro, G Navarro, Gemma Navarro, H Kaphzan, HJ Seong, IM Mazurkiewicz-Kwilecki, J Chen, J Wu, JD Brioni, Josefa Mallol, JY Koh, L Fernández-Novoa, M Wang, Mar Rodríguez-Ruiz, MB Passani, NP Sidharthan, P Giménez-Xavier, P Panula, Peter J. McCormick, PL Chazot, R Cacabelos, RA Grove, Rafael Franco, RF Cowburn, RJ Rodrigues, S Jürgensen, S-M Jeon, Vicent Casadó, WD Le   +50 more
core   +1 more source

Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms [PDF]

Nature Communications, 2014
AbstractThe role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist.
Yan, Haijing, Zhang, Xiangnan, Hu, Weiwei, Ma, Jing, Hou, Weiwei, Zhang, Xingzhou, Wang, Xiaofen, Gao, Jieqiong, Shen, Yao, Lv, Jianxin, Ohtsu, Hiroshi, Han, Feng, Wang, Guanghui, Chen, Zhong   +13 more
openaire   +3 more sources

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Histaminergic modulation of cholinergic release from the nucleus basalis magnocellularis into insular cortex during taste aversive memory formation. [PDF]

PLoS ONE, 2014
The ability of acetylcholine (ACh) to alter specific functional properties of the cortex endows the cholinergic system with an important modulatory role in memory formation. For example, an increase in ACh release occurs during novel stimulus processing,
Liliana Purón-Sierra, María Isabel Miranda   +1 more
doaj   +1 more source

Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice [PDF]

, 2015
Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS).
Alijanpour, Sakineh., Amini-Khoei, Hossein., Amiri, Shayan., Dehpour, Ahmad Reza., Ejtemaie Mehr, Shahram., Gooshe, Maziar., Haj-Mirzaian, Arya., Hassanipour, Mahsa., Rahimi-Balaei, Maryam., Shirzadian, Armin.   +9 more
core  

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source