Results 141 to 150 of about 98,227 (378)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry. [PDF]

Proc Natl Acad Sci U S A, 2023
Peng JY, Qi ZX, Yan Q, Fan XJ, Shen KL, Huang HW, Lu JH, Wang XQ, Fang XX, Mao L, Ni J, Chen L, Zhuang QX.   +12 more
europepmc   +1 more source

Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice

Journal of Pharmacological Sciences, 2009
Histamine H3 receptors inhibit the release of not only histamine itself, but also other neurotransmitters including dopamine. Previous papers have reported that histaminergic neurons inhibit psychostimulant-induced behavioral changes.
Tomohiro Okuda, Dongying Zhang, He Shao, Nobuyuki Okamura, Naoko Takino, Tatsunori Iwamura, Eiko Sakurai, Takeo Yoshikawa, Kazuhiko Yanai   +8 more
doaj  

Accuracy of direct gradient sensing by cell-surface receptors [PDF]

arXiv, 2009
Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion.
arxiv  

RECEPTORS FOR NORADRENALINE AND HISTAMINE IN THE RABBIT'S POSTERIOR VENA CAVA [PDF]

, 1968
O.D. Gulati, H. M. PARIKH, M S Umar
openalex   +1 more source

Overexpressing temperature-sensitive dynamin decelerates phototransduction and bundles microtubules in drosophila photoreceptors [PDF]

, 2009
shibire(ts1), a temperature-sensitive mutation of the Drosophila gene encoding a Dynamin orthologue, blocks vesicle endocytosis and thus synaptic transmission, at elevated, or restrictive temperatures.
Gonzalez-Bellido, P.T., Juusola, M., Kostyleva, R., Meinertzhagen, I.A., Wardill, T.J.   +4 more
core   +1 more source

Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins

Molecular Nutrition &Food Research, EarlyView.
In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang, Michelle Lee, Erika de Jesus, Katherine Weh, Connor Howard, Henriette Remmer, Amy B. Howell, Laura A. Kresty   +7 more
wiley   +1 more source

Breathing and balance: Clinical insights and management strategies of respiratory acid‐base disorders

Nutrition in Clinical Practice, EarlyView.
Abstract Respiratory acidosis and alkalosis are two of the four main acid‐base processes encountered in clinical practice. These two processes are tightly balanced by breathing. Identification and management of respiratory acid‐base disorders are important for clinicians, particularly when caring for patients with underlying pulmonary and neurological ...
Anne M. Tucker, Tami N. Johnson
wiley   +1 more source

Detection of histamine receptors on mouse oocytes and their involvement in fertilization potential. [PDF]

Vet Res Forum, 2022
Yusoff M, Hashim NH, Mohd-Yusuf Y.
europepmc   +1 more source

Serotonin as a Creativity Pump [PDF]

arXiv
The location of Western Civilization defined nations in Europe and in the United States within the largest global pollen environments on the planet is proposed as a key factor leading to their success. Environments with dense pollen concentrations will cause large up and down changes in serum histamine directly causing reductions and increases in brain
arxiv