Results 11 to 20 of about 92,808 (201)

Function and Role of Histamine H₁ Receptor in the Mammalian Heart

Pharmaceuticals, 2023
Histamine can change the force of cardiac contraction and alter the beating rate in mammals, including humans. However, striking species and regional differences have been observed. Depending on the species and the cardiac region (atrium versus ventricle)
Joachim Neumann, Britt Hofmann, Uwe Kirchhefer, Stefan Dhein, Ulrich Gergs   +4 more
doaj   +1 more source

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

Brain Sciences, 2023
Background: Histamine is a widely distributed biogenic amine with multiple biological functions mediated by specific receptors that determine the local effects of histamine.
Lingyi Kong, Ewa Domarecka, Agnieszka J. Szczepek   +2 more
doaj   +1 more source

Network adaptation improves temporal representation of naturalistic stimuli in drosophila eye: II Mechanisms [PDF]

, 2009
Retinal networks must adapt constantly to best present the ever changing visual world to the brain. Here we test the hypothesis that adaptation is a result of different mechanisms at several synaptic connections within the network.
A Borst, A Kolodziejczyk, A Nikolaev, AD Straw, AL Fairhall, AL Fairhall, Anton Nikolaev, B Wark, BG Burton, BG Burton, BN Lundstrom, Cahir J. O'Kane, CE Shannon, DG Stavenga, DJ Field, DW Dong, E Schneidman, E Warrant, EL Mah, Ernest Greene, F Attneave, G Buchsbaum, G Schwartz, GG de Polavieja, GG de Polavieja, GG de Polavieja, Gonzalo G. de Polavieja, GW Davis, H Alle, H Barlow, H Clague, HG Krapp, I Sinakevitch, IA Meinertzhagen, IA Meinertzhagen, J Rister, J Tanaka, JD Armitage, JH van Hateren, JH van Hateren, JH van Hateren, JH van Hateren, JH van Hateren, JH van Hateren, JJ Atick, JJ Atick, JL Puchalla, K Götz, K Kirschfeld, L Zheng, Lei Zheng, M Heisenberg, M Heisenberg, M Juusola, M Juusola, M Juusola, M Juusola, M Juusola, M Juusola, M Juusola, M Juusola, M Juusola, M Juusola, M Järvilehto, M Land, M Stemmler, M Weckstrom, Mikko Juusola, MV Srinivasan, N Brenner, N Uchida, O Faivre, O Sayeed, R Hummel, R Kern, R Linsker, R Segev, R Wolf, RC Hardie, RO Uusitalo, RR de Ruyter van Steveninck, RS Brinkworth, S Laughlin, S Tang, SA Baccus, SB Laughlin, SB Laughlin, SM Smirnakis, SN Fry, SN Fry, SR Shaw, ST Hong, T Gollisch, TM Cover, TO Sharpee, Trevor J. Wardill, V Wolfram, XJ Wang, Y Dan, Y Shu   +99 more
core   +14 more sources

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]

, 2020
Inflammatory mediators may have a role in various lower urinary tract disorders. Histamine is known to induce significant increases in both the tension and frequency of spontaneous phasic contractions in both urothelium with lamina propria (U&LP) and
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis

Viruses, 2023
Although Kaposi’s sarcoma-associated herpesvirus (KSHV) has been reported to cause several human cancers including Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL), the mechanisms of KSHV-induced tumorigenesis, especially virus–host interaction ...
Jungang Chen, Jiao Song, Karlie Plaisance-Bonstaff, Shengyu Mu, Steven R. Post, Lu Dai, Zhiqiang Qin   +6 more
doaj   +1 more source

Interactions between Histamine H1 and H3 and Dopamine D1 Receptors on feeding behavior in chicken [PDF]

Iranian Journal of Veterinary Medicine, 2017
BACKGROUND: Brain monoamines (such as histamine and dopamine) play an important role in emotions, cognition, reward and feeding behavior. The interactions between histamine and dopamine were studied in many physiological functions but this correlation is
Masood GhandForoushan, Morteza Zendehdel, Vahab Babpour   +2 more
doaj   +1 more source

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

Journal of Neuroinflammation, 2020
Background Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND).
Yi-Nan Chen, Huan-Huan Sha, Yi-Wei Wang, Qin Zhou, Piplu Bhuiyan, Na-Na Li, Yan-Ning Qian, Hong-Quan Dong   +7 more
doaj   +1 more source

Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis

Acta Dermato-Venereologica, 2020
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch.
Kristine Rossbach, Katharina Wahle, Gustav Bruer, Ralph Brehm, Marion Langeheine, Kristina Rode, Katrin Schaper-Gerhardt, Ralf Gutzmer, Thomas Werfel, Manfred Kietzmann, Wolfgang Bäumer   +10 more
doaj   +1 more source

Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice

Frontiers in Pharmacology, 2022
Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host’s immunological responses at the feeding site. We hypothesized that
Ibrahim Alrashdi, Ibrahim Alrashdi, Amal Alsubaiyel, Amal Alsubaiyel, Michele Chan, Michele Chan, Emma E. Battell, Abdel Ennaceur, Miles A. Nunn, Wayne Weston-Davies, Paul L. Chazot, Ilona Obara, Ilona Obara   +12 more
doaj   +1 more source

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons [PDF]

, 2016
Zolpidem, a GABAA receptor-positive modulator, is the gold-standard drug for treating insomnia. Zolpidem prolongs IPSCs to decrease sleep latency and increase sleep time, effects that depend on α2 and/or α3 subunit-containing receptors.
Brickley, SG, Franks, NP, Harding, EC, Uygun, DS, Vyssotski, AL, Wisden, W, Ye, Z, Yu, X, Yustos, R, Zecharia, AY   +9 more
core   +4 more sources