Results 31 to 40 of about 53,829 (294)

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster [PDF]

, 2009
Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage.
Bartness, Timothy J., Barrett, Perry, van den Top, Marco, Spanswick, David C., Wilson, D., Mercer, Julian G., Morgan, Peter J., Song, C. K.   +7 more
core   +1 more source

The Affinity of Histamine for Gq Protein-Coupled Histamine H1-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells

Journal of Pharmacological Sciences, 2012
We examined the regulatory mechanisms of the affinity of Gq protein-coupled histamine H1-receptors for histamine after histamine pretreatment in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma, Yuko Sato, Chizuru Akatsu, Masaru Shoji   +3 more
doaj   +1 more source

Histamine and migraine revisited: mechanisms and possible drug targets

The Journal of Headache and Pain, 2019
Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm, Katrine Falkenberg, Jes Olesen   +2 more
doaj   +1 more source

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

Pharmaceuticals, 2023
Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins.
Szczepan Mogilski, Monika Kubacka, Artur Świerczek, Elżbieta Wyska, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz, Dorota Łażewska   +7 more
doaj   +1 more source

Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods

, 2011
In the last three decades, a large amount of experimental data (for example Förster resonance energy transfer (FRET) at fluorescently labelled receptors) supported the hypothesis of the dimerization of G-protein-coupled receptors (GPCR), including ...
Lopuch, Miroslaw
core   +1 more source

Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation. [PDF]

PLoS ONE, 2014
BACKGROUND: Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is crucially influenced by different T-helper subsets. However, the contribution of different
Subhashree Mahapatra, Melanie Albrecht, Barbara Behrens, Adan Jirmo, Georg Behrens, Christina Hartwig, Detlef Neumann, Ulrike Raap, Heike Bähre, Christina Herrick, Anna-Maria Dittrich   +10 more
doaj   +1 more source

Perioperative uses of histamine antagonists

, 1990
Histamine release and adverse pseudoallergic/allergic reactions during the perioperative period occur frequently. The incidence of such reactions is 20%-30% for all grades of severity, 1%-5% for systemic reactions, and 0.1%-0.5% for life-threatening ...
Lorenz, Wilfried, Doenicke, A., Ennis, M., Dick, W.   +3 more
core   +1 more source

Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic cells

Haematologica, 2012
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial.
Johan Aurelius, Anna Martner, Mats Brune, Lars Palmqvist, Markus Hansson, Kristoffer Hellstrand, Fredrik B. Thoren   +6 more
doaj   +1 more source

Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat

, 2004
Background: In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g.,
Panula, Pertti, Lozada, Adrian F., Kaj Karlstedt, Karlstedt, Kaj, Aarnisalo, Antti A., Stark, Holger, Adrian F Lozada, Pertti Panula, Antti A Aarnisalo, Holger Stark   +9 more
core   +1 more source

Molecular analysis of the histamine H3-receptor

, 2010
The histamine H3 receptor (H3R) is a biogenic amine receptor that belongs to family I of G protein-coupled receptors (GPCRs). During the past two decades, the H3R has gained much interest in academia and industry.
Schnell, David
core   +1 more source