Results 31 to 40 of about 659,937 (298)
Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal. [PDF]
J Neurogastroenterol Motil, 2017 Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for ...
Fabisiak A +4 more
europepmc +2 more sources
Histamine, histamine receptors, and neuropathic pain relief [PDF]
Histamine, acting via distinct histamine H1 , H2 , H3 , and H4 receptors, regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of ...
Telezhkin V +3 more
core +3 more sources
Targeted therapy with histamine antagonists - New challenges to fight with breast cancer
Journal of Education, Health and Sport, 2022 Breast cancer (BC) is currently the most commonly diagnosed cancer in women. BC is most often derived from the epithelial tissue of the mammary gland and is a global problem due to the steady increase in morbidity and mortality in most countries.
Piotr Jan Więsyk +5 more
doaj +1 more source
Molecular analysis of the histamine H3-receptor [PDF]
, 2010 The histamine H3 receptor (H3R) is a biogenic amine receptor that belongs to family I of G protein-coupled receptors (GPCRs). During the past two decades, the H3R has gained much interest in academia and industry.
Schnell, David
core +1 more source
Journal of Pharmacological Sciences, 2012 We examined the regulatory mechanisms of the affinity of Gq protein-coupled histamine H1-receptors for histamine after histamine pretreatment in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma +3 more
doaj +1 more source
Granuloma pouch and skin histamine of the rat [PDF]
, 1958 Using the granuloma pouch technique of SELYE, effect of modification in local histamine on the inflammatory tissue reactions was examined in rats. The increase in the weight of pouch wall and histological inflammatory changes were distinctly inhibited in
Irino, Shozo
core +1 more source
Molecular Pharmacology of the Four Histamine Receptors
, 2010 Histamine and its receptors have been (and are still today) very fruitful topics for pharmacological and medicinal chemistry studies. In this chapter we review the various selective ligands that are available for the four different histamine receptors ...
Bongers, G +5 more
core +2 more sources
Histamine and migraine revisited: mechanisms and possible drug targets
The Journal of Headache and Pain, 2019 Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm +2 more
doaj +1 more source
Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins
Pharmaceuticals, 2023 Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins.
Szczepan Mogilski +7 more
doaj +1 more source
Haematologica, 2012 Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial.
Johan Aurelius +6 more
doaj +1 more source