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The new biology of histamine receptors
Current Allergy and Asthma Reports, 2008The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histamine compared with the histamine H1 ...
Robin L. Thurmond, Jing-Feng Huang
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Histamine Receptors in the Lung
1991Histamine, which has long been implicated as a mediator of allergic airway disease, has multiple effects on airways which are mediated by at least three histamine receptors. H1-receptors mediate bronchoconstriction, vasoconstriction and dilatation, microvascular leak and activation of sensory nerves.
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Histamine and Histamine Receptors in Health and Disease
2017Part 1: New Analytical tools.- Histamine and histamine receptors: State of the art.- Mass-spectrometric methods for the detection of histamine and histamine metabolites.- Fluorescent ligands and radioligands for the analysis of histamine receptors.- Molecular analysis of histamine receptors: Structural analysis of the histamine H1-receptor.- Molecular ...
Roland. Seifert, Yuichi Hattori
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HISTAMINE RECEPTORS IN THE HUMAN NOSE
Clinical Otolaryngology, 1994The aim of this study was to determine the role of histamine receptors in the nose. The effects of intranasal histamine challenge were compared with those of a specific H1-receptor agonist, betahistine and a specific H2-receptor agonist, impromidine, in 11 normal individuals and four with rhinitis.
D. Shelton, N. Eiser
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Session 2: Histamine Receptors: An Overview
Scandinavian Journal of Gastroenterology, 1991Histamine is widely distributed throughout the body and has a broad range of pharmacologic effects. The advent of selective agonists and antagonists has allowed the identification and characterization of three types of histamine receptor. These same compounds have helped in our understanding of physiologic and pathologic roles for histamine.
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Histamine receptors in primate gallbladder
Digestive Diseases and Sciences, 1983The effect of intravenous histamine on intragallbladder pressure (GBp) and subsequent modification of the histamine response by H1- and H2-antagonists was investigated in an awake baboon model. Responses to specific H1- and H2-agonists were also examined in order to further elucidate gallbladder histamine responses.
W. E. Wise +4 more
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The Role of Histamine Receptors in Asthma
Clinical Science, 19811. Eighteen non-asthmatic and 18 asthmatic subjects underwent challenge with increasing doses of histamine from a dosimeter—nebulizer system. Half the subjects in each group were atopic and half non-atopic. Bronchial response was monitored with serial measurements of specific airways conductance (sGaw) and a dose-response curve was constructed for each
Noemi M. Eiser +3 more
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Histamine Receptors in the Synovial Microcirculation
European Journal of Clinical Investigation, 1975Abstract. This study was designed to investigate the respective roles of H1 and H2 receptors in the control of the microcirculation by examining the effectiveness of the H2 receptor antagonist metiamide (Met.) and Hj receptor antagonist mepyramine is blocking the action of histamine on synovial perfusion. Synovial perfusion was monitored indirectly by
D. M. Grennan +5 more
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Histamine receptors in the human ureter
Pharmacological Research Communications, 1983The occurrence of histamine H1- and H2-receptors in the human ureter was studied by means of relatively selective agonists and antagonists of both kinds of receptors. Isolated preparations of small strips of human ureters removed during surgery were used.
Giulio Bertaccini +3 more
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