Results 121 to 130 of about 147,237 (374)

Population Pharmacokinetics of Fruquintinib, a Selective Oral Inhibitor of VEGFR ‐1, ‐2, and ‐3, in Patients with Refractory Metastatic Colorectal Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib is a selective, oral tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors 1, 2, and 3, which is approved for patients with previously treated metastatic colorectal cancer regardless of biomarker status. This population pharmacokinetic (PK) analysis characterized sources of interpatient variability on
Xiaofei Zhou, Xiaoyan Yang, Boris Grinshpun, Adekemi Taylor, Laura Strong, Arvind Dasari, Andrea Wang‐Gillam, Jin Li, Rui‐Hua Xu, Neeraj Gupta, Caly Chien   +10 more
wiley   +1 more source

Prostaglandin D2 Inhibits IgE-Mediated Scratching by Suppressing Histamine Release From Mast Cells

Journal of Pharmacological Sciences, 2005
Effects of prostaglandin (PG) D2, PGE2, and PGI2 on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined.
Yuki Hashimoto, Iwao Arai, Makoto Tanaka, Shiro Nakaike   +3 more
doaj  

Honeycomb-like Structured Film Regulates Mediator Release from Non-Tumor Mast Cells

European Journal of Inflammation, 2014
We previously reported a honeycomb-like structured film (HCF) stimulates mast cell proliferation and multinucleated formation. In this study, we examined the role of HCF in regulating the release of mediators from cultured mast cells.
K. Sugimoto, H. Choi, M. Tanaka
doaj   +1 more source

The LAMOST Data Archive and Data Release [PDF]

arXiv, 2016
The Large sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) is the largest optical telescope in China. In last four years, the LAMOST telescope has published four editions data (pilot data release, data release 1, data release 2 and data release 3).
arxiv  

Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke. [PDF]

J Neuroinflammation, 2023
Conesa MPB, Blixt FW, Peesh P, Khan R, Korf J, Lee J, Jagadeesan G, Andersohn A, Das TK, Tan C, Di Gesu C, Colpo GD, Moruno-Manchón JF, McCullough LD, Bryan R, Ganesh BP.   +15 more
europepmc   +1 more source

Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review

Journal of General and Family Medicine, EarlyView.
Abstract Objectives This narrative review identifies pitfalls in managing constipation in older adults and provides evidence‐based recommendations to avoid them. Methods A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in ...
Madunil Niriella, Hiruni Jayasena, Prathibha Wijesingha, Janaka de Silva   +3 more
wiley   +1 more source

Association of a SYK promoter polymorphism with SYK expression and IgE-mediated histamine release. [PDF]

Clin Exp Allergy, 2023
MacGlashan D, Gao L.
europepmc   +1 more source

Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real‐Time Chemical Analysis

Mass Spectrometry Reviews, EarlyView.
ABSTRACT In the 1980s, researchers discovered the remarkable ability of electrospray plumes to effectively ionize gas‐phase molecules via secondary ionization. Around 20 years later—coinciding with the ambient mass spectrometry revolution—secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) coupled to mass spectrometry
Xin Luo, Huiling Wang, Xiaolan Hu, Sasho Gligorovski, Xue Li, Pablo Sinues   +5 more
wiley   +1 more source

Evidence for histamine release in chronic inducible urticaria - A systematic review. [PDF]

Front Immunol, 2022
Kulthanan K, Church MK, Grekowitz EM, Hawro T, Kiefer LA, Munprom K, Nanchaipruek Y, Rujitharanawong C, Terhorst-Molawi D, Maurer M.   +9 more
europepmc   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source