Results 51 to 60 of about 147,237 (374)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

open access: yesAdvanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen   +12 more
wiley   +1 more source

Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses

open access: yesPlants, 2018
Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is well documented that Spirulina exerts anti-inflammatory effects and
Kurt Appel   +5 more
doaj   +1 more source

Pharmacologic regulation of histamine release by the human recombinant histamine-releasing factor

open access: yesJournal of Allergy and Clinical Immunology, 1999
The recently cloned human recombinant IgE-dependent histamine releasing factor (HrHRF) was initially thought to stimulate histamine release from human basophils from a subpopulation of allergic donors by interacting with the IgE molecules on the surface of these cells.
Susan M. MacDonald   +4 more
openaire   +3 more sources

Effects of Flavonoids Isolated From Orange Jasmine (Murraya Paniculata [L.] Jack.) on Histamine Release From Mast Cells [PDF]

open access: yes, 2010
Murraya paniculata [L.] Jack. (Kemuning) is a plant that grows widely in some areas of Indonesia. Studies related to this plant have been widely explored especially isolation of its active compounds.
Maeyama, K. (Kazutaka)   +3 more
core  

Histamine activates an intracellular Ca2+ signal in normal human lung fibroblast WI-38 cells

open access: yesFrontiers in Cell and Developmental Biology, 2022
Histamine is an inflammatory mediator that can be released from mast cells to induce airway remodeling and cause persistent airflow limitation in asthma.
Roberto Berra-Romani   +11 more
doaj   +1 more source

Microneedle Patch for In Situ Neutrophil Monitoring

open access: yesAdvanced Science, EarlyView.
An in situ chromogenic microneedle patch that achieves daily blood neutrophil monitoring without vascular invasion or laboratory apparatus is developed. The detection ability is well demonstrated in a chemotherapy‐induced neutropenic rat model and can be read out using a mobile phone application.
Ziyi Lu   +26 more
wiley   +1 more source

In Situ Electrically Resettable Field‐Effect Transistor Biosensors for Continuous and Multiplexed Neurotransmitter Detection

open access: yesAdvanced Science, EarlyView.
The research team integrated a potentiometrically controlled pH electrode with carbon nanotube (CNT) field‐effect transistor (FET) biosensors on a single chip using compatible processes. By employing zonal modification and optimized pH‐sensitive probes, they achieved simultaneous quadruple‐target detection and tenfold reusability under physiological ...
Bo Xiao   +6 more
wiley   +1 more source

The role of histamine in neurogenic inflammation [PDF]

open access: yes, 2013
The term ‘neurogenic inflammation’ has been adopted to describe the local release of inflammatory mediators, such as substance P and calcitonin gene-related peptide, from neurons.
Fantozzi, Roberto   +1 more
core   +1 more source

An Empirical Study of Delayed Games on Steam [PDF]

open access: yesarXiv, 2022
The gaming industry is rapidly expanding. With over 2.7 billion players worldwide, game development has become increasingly challenging. To meet the ever-changing demands and expectations of players and due to unforeseen hindrances in the development process, game developers may require to delay the release of their game.
arxiv  

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

open access: yesAdvanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen   +6 more
wiley   +1 more source

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