Results 191 to 200 of about 265,522 (247)

Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks

open access: yesChemistry – A European Journal, EarlyView.
A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan   +8 more
wiley   +1 more source

Construction of Phospholipid‐Like Vesicles by Aqueous Aminolysis of Acyl Thioesters With Diamino Acids

open access: yesChemistry – A European Journal, EarlyView.
Membrane‐forming phospholipids are produced in cells via enzymatic diacylation. Here, we show that direct aminolysis of acyl thioesters with diamino acids in aqueous environments enables the synthesis of diacylated amino acids (DAAAs), which spontaneously self‐assemble into robust phospholipid‐like vesicles across a broad range of pH and temperature ...
Federica A. Souto‐Trinei   +2 more
wiley   +1 more source

Functional Analysis of Histidine-Dependent Self-Cleaving RNAs Obtained by In Vitro Selection. [PDF]

open access: yesChembiochem
Sakimoto N   +8 more
europepmc   +1 more source

Intermediate CuIIATCUN Species Reacts With Biomolecules Within Time Windows of Biological Processes

open access: yesChemistry – A European Journal, EarlyView.
We have demonstrated that a partially coordinated intermediate species formed in a multistep reaction of the Cu(II) ion with a model peptide representing the N‐terminus of Human Serum Albumin exhibits remarkable lability and redox‐activity, which strongly supports its physiological relevance.
Iwona Ufnalska, Wojciech Bal
wiley   +1 more source

Insights into Photo Degradation and Stabilization Strategies of Antibody-Drug Conjugates with Camptothecin Payloads. [PDF]

open access: yesPharmaceutics
Luo S   +10 more
europepmc   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

open access: yesCytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas   +5 more
wiley   +1 more source

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