Results 201 to 210 of about 291,783 (305)

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +2 more sources

Copper-histidine therapy: a targeted metabolic intervention for Menkes disease. [PDF]

Ann Med Surg (Lond)
Batool A, Mahmood H, Awan A, Saeed MZ, Qureshi AA, Qamar MA.   +5 more
europepmc   +1 more source

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, EarlyView.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, EarlyView.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources

Preparation and Properties of <i>Camellia oleifera</i> Fruit Shell Cellulose Nanoparticle Material for Selective Enrichment of Histidine Proteins From Foods. [PDF]

Int J Food Sci
Tian Y, Li W, Li L, Li D, Liu Y, Tang X, Ye Y.   +6 more
europepmc   +1 more source

Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis. [PDF]

Nat Commun
Hunt DM, Pisco JP, Rodgers A, de Chiara C, Zaveri A, Pacholarz KL, Evangelopoulos D, Garza-Garcia A, Ehrt S, Schnappinger D, Barran PE, Gutierrez MG, de Carvalho LPS.   +12 more
europepmc   +1 more source

Proteins Rich in Prime Mass Residues and Their Role in Cell Biology. [PDF]

Evol Bioinform Online
Wright M, Downard KM.
europepmc   +1 more source

Substrate selectivity of human histidine methyltransferase METTL9. [PDF]

Protein Sci
Ahmad S, Moesgaard L, Tornøe CW, Emmel P, Slusarczyk K, Drozak J, Kongsted J, Mecinović J.   +7 more
europepmc   +1 more source

Correction: Acylation of Lysine 983 Is Sufficient for Toxin Activity of Bordetella pertussis Adenylate Cyclase. [PDF]

J Biol Chem
Basar T, Havlíček V, Bezoušková S, Hackett M, Ŝebo P.   +4 more
europepmc   +1 more source

Genetic Incorporation of Diverse Noncanonical Amino Acids for Histidine Substitution. [PDF]

J Am Chem Soc
Natter Perdiguero A, Fischer S, Lischke AR, Manser BP, Deliz Liang A.   +4 more
europepmc   +1 more source