Results 141 to 150 of about 26,891 (179)

Mechanism of inhibition of histidine decarboxylase by rhodanines

Biochemical Pharmacology, 1971
Abstract The inhibition of rat gastric histidine decarboxylase in vitro by rhodanine and 26 of its 3- or 5-substituted derivatives has been investigated. Inhibitory activities of the 3-substituted derivatives of rhodanine ranged from i 50 values of 2 × 10−6 M to 2 × 10−4 M.
C A, Free, E, Majchrowicz, S M, Hess
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Effect of metabolite antagonists on histidine decarboxylase*

Journal of the American Pharmaceutical Association (Scientific ed.), 1949
The results of a study of histidine decarboxylase metabolite antagonists are reported. The compounds used in the study included a series of vitamin antagonists, compounds containing phenolic hydroxyl groups and compounds structurally related to histidine.
J.M. Beiler, Robert Brendel, Miriam Graff, Gustav J. Martin   +3 more
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Histidine decarboxylase in the fetal rat

Biochemical Pharmacology, 1963
Abstract The properties of a purified preparation of histidine decarboxylase from fetal rat tissues have been studied. From kinetic data there is reason to believe that the enzyme requires the anionic form of the substrate and that the active form of the enzyme occurs more abundantly at acid pH. Pyridoxal-5-phosphate is required as a coenzyme.
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Mammalian histidine decarboxylase: Effect by protein kinase on mouse mastocytoma histidine decarboxylase

Agents and Actions, 1983
Mouse mastocytoma histidine decarboxylase is decreased in activity when, in crude preparations, incubated with a cAMP-dependent protein kinase. This effect was not seen with purified preparations of the histidine decarboxylase (specific activity 7-13 mumol X mg-1 X h-1).
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4 The Histidine Decarboxylases

1967
Publisher Summary This chapter explores that histidine, β-4(5)-imidazolyl-α-aminopropionic acid (III), is one of the essential amino acids. From the pharmacological point of view, it is of particular importance as it is the immediate precursor of the highly active amine histamine, β-4(5)-imidazolylethylamine (IV).
D.M. Shepherd, D. MaCkay
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PROPERTIES OF RAT BRAIN HISTIDINE DECARBOXYLASE

Journal of Neurochemistry, 1976
Abstract– The properties of histidine decarboxylase (l‐histidine carboxylyase EC 4.1,1.22) have been studied in a whole rat brain homogenate. Optimum pH depended upon substrate concentration; the variations of Km and Vmax were determined as a function of pH.
J M, Palacios, G, Mengod, F, Picatoste, M, Grau, I, Blanco   +4 more
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Characterization of ornithine decarboxylase with histidine decarboxylase activity in natural histidine decarboxylase gene deletion Enterobacter hormaechei RH3

Food Microbiology
Histamine is predominantly produced in sausages via the decarboxylation of histidine by bacteria. Furthermore, histamine-producing bacteria usually possess the enzyme histidine decarboxylase (hdc). Enterobacter hormaechei RH3 isolated from sausages exhibited significant levels of histamine production despite the absence of hdc.
Huijie, Pei, Yilun, Wang, Wei, He, Yue, Zhang, Lamei, Yang, Jinhai, Li, Yixuan, Ma, Xinjie, Hu, Shuhong, Li, Jianlong, Li, Kaidi, Hu, Aiping, Liu, Xiaolin, Ao, Hui, Teng, Ran, Li, Qin, Li, Likou, Zou, Shuliang, Liu, Yong, Yang   +18 more
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Peptide inhibition of mammalian histidine decarboxylase

Agents and Actions, 1979
The hypothesis that N-terminal histidine peptides might act as inhibitors to histidine decarboxylase was investigated. A murine mastocytoma was utilized as enzyme source. The crude extract of this tissue exhibits high rates of decarboxylation of both histidine and DOPA and was used to establish the specificity in the effect of the compounds tested. For
L, Hammar, U, Ragnarsson
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Histidine decarboxylase in the bone marrow of the rat

Experientia, 1964
Dans l'etude ci-dessus la formation d'histamine dans la moelle osseuse du rat adulte a ete attribuee a une enzyme identique ou semblable a la decarboxylase d'histidine du rat foetal. Par consequence, l'enzyme de la moelle osseuse differe de l'enzyme qui, etant presente dans l'ecorce renale des animaux adultes, forme l'histamine.
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Histidine decarboxylase inhibition and gastric secretion

The American Journal of Digestive Diseases, 1967
In a series of rats whose histamine formation was blocked by either pyridoxine deficiency or decarboxylase inhibition with 4-bromo-3-hydroxybenzy-oxyamine dihydrogen phosphate (NSD-1055), we found that basal and gastrin-stimulated gastric secretion was markedly lowered.
W R, Thayer, H F, Martin
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