Bacterial Histidine Kinase and the Development of Its Inhibitors in the 21st Century [PDF]
AntibioticsBacterial histidine kinase (BHK) is a constituent of the two-component signaling (TCS) pathway, which is responsible for the regulation of a number of processes connected to bacterial pathogenicity, virulence, biofilm development, antibiotic resistance ...
Ragib Ahsan +7 more
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Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase [PDF]
Nature Communications, 2017 Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a ...
Oskar Berntsson +19 more
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Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks. [PDF]
PLoS Computational Biology, 2013 Bacteria sense and respond to their environment through signaling cascades generally referred to as two-component signaling networks. These networks comprise histidine kinases and their cognate response regulators.
Munia Amin +2 more
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Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle [PDF]
Journal of Biological Engineering, 2023 Background Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses.
Rajesh Kumar Pathak, Jun-Mo Kim
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Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain [PDF]
Journal of Molecular Biology, 2016 In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism.
Jimena Rinaldi +2 more
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Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking [PDF]
Science Advances, 2016 Histidine kinases are key components of regulatory networks in bacteria. Although many of these enzymes are bifunctional, mediating both phosphorylation and dephosphorylation of downstream targets, the molecular details of this central regulatory switch ...
Badri N Dubey +2 more
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KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally [PDF]
Nature CommunicationsTwo-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli.
Jakob M. Silberberg +6 more
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Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents [PDF]
Frontiers in Chemistry, 2022 The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and develop novel antibacterial drugs.
Hongtong Chen +11 more
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Mechanism of activation and autophosphorylation of a histidine kinase [PDF]
Communications ChemistryHistidine kinases (HK) are one of the main prokaryotic signaling systems. Two structurally conserved catalytic domains inside the HK enable autokinase, phosphotransfer, and phosphatase activities. Here, we focus on a detailed mechanistic understanding of
Mayukh Kansari +4 more
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Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli [PDF]
MoleculesBackground: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat.
Youqi Ji +8 more
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