Bacterial Histidine Kinase and the Development of Its Inhibitors in the 21st Century [PDF]
AntibioticsBacterial histidine kinase (BHK) is a constituent of the two-component signaling (TCS) pathway, which is responsible for the regulation of a number of processes connected to bacterial pathogenicity, virulence, biofilm development, antibiotic resistance ...
Ragib Ahsan +7 more
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Mechanism of activation and autophosphorylation of a histidine kinase [PDF]
Communications ChemistryHistidine kinases (HK) are one of the main prokaryotic signaling systems. Two structurally conserved catalytic domains inside the HK enable autokinase, phosphotransfer, and phosphatase activities. Here, we focus on a detailed mechanistic understanding of
Mayukh Kansari +4 more
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Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle [PDF]
Journal of Biological Engineering, 2023 Background Mastitis poses a major threat to dairy farms globally; it results in reduced milk production, increased treatment costs, untimely compromised genetic potential, animal deaths, and economic losses.
Rajesh Kumar Pathak, Jun-Mo Kim
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Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira [PDF]
Nature CommunicationsPathogenic Leptospira modulate their virulence via the Lvr signaling system, with the histidine kinase LvrB being a central element. LvrB is a prototype of Rec-controlled histidine kinases, which are frequently found in bacterial two-component systems ...
Elia Agustoni +12 more
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KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally [PDF]
Nature CommunicationsTwo-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli.
Jakob M. Silberberg +6 more
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Structural mechanism of signal transduction in a phytochrome histidine kinase [PDF]
Nature Communications, 2022 In this study, authors have solved cryo-EM structures of a bacteriophytochrome in its dark-adapted and illuminated states. The structures reveal the structural mechanism for photoactivation of the phytochrome.
Weixiao Yuan Wahlgren +7 more
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Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli [PDF]
MoleculesBackground: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat.
Youqi Ji +8 more
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 [PDF]
Microbiology SpectrumRalstonia pseudosolanacearum strain OE1-1 secretes methyl 3-hydroxymyristate (3-OH MAME) as a quorum-sensing (QS) signal. Strain OE1-1 senses the chemical by the sensor histidine kinase PhcS, leading to the activation of the LysR family transcriptional ...
Wakana Senuma +7 more
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PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer [PDF]
The EMBO JournalPhosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation.
Yang Wang +18 more
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A Dual Regulatory Role of the PhoU Protein in Salmonella Typhimurium
mBio, 2022 Bacteria utilize two-component regulatory systems to sense and respond to their surroundings. Unlike other two-component systems that directly sense through a sensory domain in the histidine kinase (HK), the PhoB/PhoR two-component system requires ...
Soomin Choi +3 more
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